Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 483  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


ORIGINAL ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 32-36

Synthesis and antimicrobial activity of 2-chloroquinoline incorporated pyrazoline derivatives


1 Department of Pharmaceutical Chemistry, Jamia Hamdard (Hamdard University), New Delhi - 110 062, India
2 Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi - 110 062, India

Correspondence Address:
Suresh Kumar
Department of Pharmaceutical Chemistry, Jamia Hamdard (Hamdard University), New Delhi - 110 062
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.62684

Rights and Permissions

Purpose : A series of 2-chloroquinoline containing pyrazoline derivatives having 3,4-dichloro/ 3,4-dimethoxy in the phenyl ring were synthesized and screened for their antimicrobial activity against a panel of bacterial and fungal strains. Materials and Methods : The structures of the newly synthesized compounds were established on the basis of spectral data obtained from the FTIR, 1H and 13C-NMR, and mass spectrometry. All the compounds were evaluated for their antibacterial activity against Escherichia coli (NCTC, 10418), Staphylococcus aureus (NCTC, 65710), and Pseudomonas aeruginosa (NCTC, 10662). The compounds were also tested for antifungal activity aganist Aspergillus niger (MTCC, 281), Aspergillus flavus (MTCC, 277), Monascus purpureus (MTCC, 369) and Penicillium citrinum (NCIM, 768) by the cup-plate method. Results : Among the compounds tested, 3,4-dichloro derivatives were comparatively more active in antimicrobial screening with respect to their 3,4-dimethoxy analog. Conclusion : A careful analysis of the antimicrobial activity data of the compounds revealed that compounds 3a, 3b, 3c, and 3e exhibited potent antibacterial


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3675    
    Printed152    
    Emailed0    
    PDF Downloaded563    
    Comments [Add]    
    Cited by others 1    

Recommend this journal