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ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 1  |  Page : 44-46

Screening of nutrient parameters for mevastatin production by Penicillium citrinum MTCC 1256 under submerged fermentation using the Plackett-Burman design


Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062, India

Correspondence Address:
Mohd. Mujeeb
Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062
India
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Source of Support: UGC, India, Conflict of Interest: None


DOI: 10.4103/0975-7406.62709

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Objective : Mevastain, an HMG-CoA reductase inhibitor produced by Penicillium citrinum. The Placket-Burman experimental design was used to identify the important nutrients influencing the production of mevastatin by Penicillium citrinum MTCC 1256 under submerged fermentation. Materials and Methods : Nine nutritional parameters, such as, glucose, glycerol, arrowroot, oats, urea, peptone, yeast extract, MgSO 4 .7H 2 O, and CaCl 2 .2H 2 O were screened by Placket-Burman experimental design in 12 experimental run. Results : Nine nutritional parameters, glucose, glycerol, arrowroot, oats, urea, peptone, yeast extract, MgSO 4 .7H 2 O, and CaCl 2 .2H 2 O contributed with 0.8114%, 24.0390%, 2.2786%, 0.1491%, 0.5608%, 47.5029%, 6.8092 %, 4.0980%, 10.5823% respectively towards mevastatin production by Penicillium citrinum under submerged fermentation. Conclusion : Among the nine nutrient components glycerol, peptone, yeast extract, MgSO 4 .7H 2 0, and CaCl 2 .2H 2 O contributed to a large extent, urea had little impact, while glucose, oats, and arrowroot contributed moderately on production of mevastatin.


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