Journal of Pharmacy And Bioallied Sciences
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SYMPOSIUM
Year : 2011  |  Volume : 3  |  Issue : 1  |  Page : 39-59

Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions


Department of Biological Sciences, University of Calgary, T2N 1N4 Calgary, AB, Canada

Correspondence Address:
Elmar J Prenner
Department of Biological Sciences, University of Calgary, T2N 1N4 Calgary, AB
Canada
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Source of Support: MHC was supported by a NSERC CGS-M and a CIHR team grant "novel alternatives to antibiotics" (EJP is one of the team PIs), Conflict of Interest: None


DOI: 10.4103/0975-7406.76463

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Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times, more attention has been applied to lipid-based drug delivery systems and drug interactions with biomimetic membranes. Highly reproducible phase transitions have been used to determine values, such as, the type of binding interaction, purity, stability, and release from a drug delivery mechanism. This review focuses on the use of DSC for biochemical and pharmaceutical applications.


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