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REVIEW ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 2  |  Page : 182-188

Myocardial infarction and stem cells


1 Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510, India
2 Department of Medicine, Meenakshi Medical College and Research Institute, Enathur, Kancheepuram, Tamilnadu, India
3 Institute for Scientific Research and Technology Services, National Secretariat for Science, Technology and Innovation, Clayton City of Knowledge, 0843-01103, Republic of Panamá
4 Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510, India; Institute for Scientific Research and Technology Services, National Secretariat for Science, Technology and Innovation, Clayton City of Knowledge, 0843-01103, Republic of Panamá

Correspondence Address:
K. R. S. Sambasiva Rao
Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510, India; Institute for Scientific Research and Technology Services, National Secretariat for Science, Technology and Innovation, Clayton City of Knowledge, 0843-01103, Republic of Panamá

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.80761

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Permanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapies lower early mortality rates, prevent additional damage to the heart muscle, and reduce the risk of further heart attacks. However, there is need for treatment to improve the infarcted area by replacing the damaged cells after MI. Thus, the cardiac tissue regeneration with the application of stem cells may be an effective therapeutic option. Recently, interest is more inclined toward myocardial regeneration with the application of stem cells. However, the potential benefits and the ability to improve cardiac function with the stem cell-based therapy need to be further addressed. In this review, we focus on the clinical applications of stem cells in the cardiac repair.


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