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Year : 2011  |  Volume : 3  |  Issue : 2  |  Page : 294-297

Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins


1 CIQA and DQF, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
2 Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal

Correspondence Address:
Amadeu F Brigas
CIQA and DQF, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139 Faro
Portugal
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.80770

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A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin (TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst.


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