Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 563  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


SYMPOSIUM – IOMC 2011
Year : 2011  |  Volume : 3  |  Issue : 3  |  Page : 339-344

The relation between QT interval and T-wave variables in hypertensive patients


Department of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania

Correspondence Address:
Ioana Mozos
Department of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara
Romania
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.84433

Rights and Permissions

Background : The standard 12-lead ECG (electrocardiogram) continues to be the most frequently recorded noninvasive test in medicine. A prolonged ECG QT interval and Tpeak-Tend (Tpe) interval are predictors of ventricular arrhythmia and sudden cardiac death. Aim : The aim of this study is to analyze the relation between QT interval and T-wave variables in hypertensive patients, with and without left ventricular hypertrophy (LVH). Materials and Methods : Fifty-nine consecutive patients with grade 2 essential hypertension were included in the study. They underwent standard 12-lead ECG, and QT intervals: QTmax (the maximal duration of the QT interval in the 12 ECG leads), QTc (heart rate corrected QTmax), QTm (mean QT interval), QTII (the QT interval in lead DII), QTcII (heart rate corrected QTII), and QTd (QT dispersion); and T-wave variables: T0e (T wave duration), T0em (mean T0e), Tpe, Tpem (mean Tpem), Ta (T wave amplitude), and Tam (mean Ta) were manually assessed. LVH was diagnosed using both echocardiography and the ECG criteria. Results : QTc was prolonged in 41 patients (69%). Multiple regression analysis revealed a significant association between QT intervals and T-wave variables: QTmax and Tpe ( P = 0.015), QTd and Tpe (P = 0.022) and Ta (P = 0.004), and Tpe with QTd and T0e (P < 0.05). A moderate but significant correlation was found between Tpe and QTmax, Tpe and QTII, and Ta and QTd. A prolonged QTc was more prevalent in hypertensive patients with LVH (85%), compared to hypertensive patients without LVH (50%). QTm, QTd, QTII, Tpe, Tpem were significantly elevated ( P < 0.05) in patients with LVH. Conclusions : Hypertension is associated with an increased prevalence of prolonged QT intervals. QT intervals and T-wave variables are closely connected in hypertensive patients. QTm, T0em, Tpem, and Tam, do not provide significant additional information compared to QTmax, T0e, Tpe, and Ta. Left ventricular hypertrophy is associated with prolonged QT interval and Tpeak-Tend interval in hypertensive patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2796    
    Printed124    
    Emailed1    
    PDF Downloaded60    
    Comments [Add]    
    Cited by others 15    

Recommend this journal