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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 1  |  Page : 66-69

Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama


1 Center for Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, Republic of Panama
2 Center for Cellular and Molecular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, Republic of Panama
3 Smithsonian Tropical Research Institute Balboa, Ancon, Republic of Panama

Correspondence Address:
Marcelino Gutierrez
Center for Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge
Republic of Panama
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Source of Support: Partially supported by the National Secretariat for Science and Technology of Panama (SENACYT, grant number COL08-061) and the Fogarty International Centerís International Cooperative Biodiversity Groups program (grant number TW006634), Conflict of Interest: None


DOI: 10.4103/0975-7406.92739

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Aim: This study was designed for isolating and characterizing antiplasmodial compounds from marine octocoral-associated bacteria. Materials and Methods: The organic extract of the Bacillus sp. was subjected to purification using several chromatography techniques guided by bioassays to yield three isocoumarin derivatives (1-3). Chemical structures of the compounds were elucidated on the basis of HRMS spectra and NMR spectroscopy. The antiplasmodial activity of the isolated compounds was evaluated in vitro against the chloroquine-resistant Plasmodium falciparum strain W2. Results: Isolated compounds were identified as bacilosarcin A (1), AI77-F (2), and AI77-H (3). Bacilosarcin A (1) displayed a low micromolar activity (IC 50 = 2.2 μM) against P. falciparum while compounds 2 and 3 showed no activity. Conclusions: Bacilosarcin A was found to be responsible for the antiplasmodial activity observed in the crude extract obtained from the Bacillus sp.


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