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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 3  |  Page : 231-235

Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl 4 -induced liver damage in rats


1 Department of Chemistry, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, Sangamner, Pune, Maharashtra; Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth University, Medical College Campus, Pune-Satara Road, Dhankwadi, Pune, Maharashtra, India
2 Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth University, Medical College Campus, Pune-Satara Road, Dhankwadi, Pune, Maharashtra, India
3 Department of Chemistry, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, Sangamner, Pune, Maharashtra, India

Correspondence Address:
D M Kasote
Department of Chemistry, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, Sangamner, Pune, Maharashtra; Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth University, Medical College Campus, Pune-Satara Road, Dhankwadi, Pune, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.99064

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Objective: to investigate the hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl 4 -induced liver damage in rats. Materials and Methods: Hepatotoxicity was induced to Wistar rats by administration of 0.2% CCl 4 in olive oil (8 mL/kg, i.p.) on the seventh day of treatment. Hepatoprotective potential of EPC-BF at doses, 250 and 500 mg/kg, p.o. was assessed through biochemical and histological parameters. Results: EPC-BF and silymarin pretreated animal groups showed significantly decreased activities of Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and level of total bilirubin, elevated by CCl 4 intoxication. Hepatic lipid peroxidation elevated by CCl 4 intoxication were also found to be alleviated at almost normal level in the EPC-BF and silymarin pretreated groups. Histological studies supported the biochemical findings and treatment of EPC-BF at doses 250 and 500 mg/kg, p.o. was found to be effective in restoring CCl 4 -induced hepatic damage. However, EPC-BF did not show dose-dependent hepatoprotective potential. EPC-BF depicted maximum protection against CCl 4 -induced hepatic damage at lower dose 250 mg/kg than higher dose (500 mg/ kg). Conclusion: EPC-BF possesses the significant hepatoprotective activity against CCl 4 induced liver damage, which could be mediated through increase in antioxidant defenses.


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