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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 4  |  Page : 327-332

Radioprotective property of an aqueous extract from valeriana wallichii


1 Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Lucknow Road, Timarpur, Delhi, India
2 Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Lucknow Road, Timarpur, Delhi; University Institute of Engineering and Technology, Maharshi Dayanand University, Rohtak, Haryana, India
3 Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organisation, Lucknow Road, Timarpur, Delhi, India

Correspondence Address:
Paban K Agrawala
Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Lucknow Road, Timarpur, Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.103272

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Objectives: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury. Materials and Methods: An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells. Results: The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution. Discussion: Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent.


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