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Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 114-115

Preparation and evaluation of cilnidipine microemulsion


The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, India

Correspondence Address:
Hemal Tandel
The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara
India
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DOI: 10.4103/0975-7406.94162

PMID: 23066184

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Cilnidipine, a calcium channel blocker having neuroprotective action and BCS Class II drug, hence formulating in Microemulsion will increase solubility, absorption and bioavailability. The formulation was prepared using titration method by tocotrienol, tween 20 and transcutol HP as oil, surfactant and co-surfactant and characterized for dilutability, dye solubility, assay (98.39±0.06), pH (6.6±1.5), Viscosity (98±1.0 cps) and Conductivity (0.2±0.09 μS/cm). The formulation was optimized on basis of percentage transmittance (99.269±0.23 at 700 nm), Globule size (13.31±4.3 nm) and zeta potential (-11.4±2.3 mV). Cilnidipine microemulsion was found to be stable for 3 months.


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