Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 3657  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 21-22

Design, development and optimization of selfmicroemulsifying drug delivery system of an anti-obesity drug


1 Department of Pharmacy, Faculty of Technology and Engineering, The Maharaja Sayajorao University of Baroda, Kalabhavan, Vadodara, Gujarat, India
2 Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India

Correspondence Address:
Jagruti Desai
Department of Pharmacy, Faculty of Technology and Engineering, The Maharaja Sayajorao University of Baroda, Kalabhavan, Vadodara, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94124

Rights and Permissions

The aim of the present work was to formulate a self-microemulsifying drug delivery system (SMEDDS) containing orlistat. The oil, surfactant and co-surfactant were decided based on the solubility studies. Pseudoternary phase diagrams were plotted, microemulsification area was determined and different formulations were prepared. Particle size, zeta potential, dispersibility test and thermodynamic stability studies were measured. In-vitro dissolution test of thermodynamically stable formulations OS-B and OS-C were carried and results were compared with those of plain drug and suspension formulation. Stability studies performed indicated that formulation OS-C remained stable over 12 months period. Thus this investigation concluded that hydrophobic drugs like orlistat can be delivered effectively through the formulation of SMEDDS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1675    
    Printed86    
    Emailed0    
    PDF Downloaded126    
    Comments [Add]    
    Cited by others 1    

Recommend this journal