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ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 23-24  

Formulation of indomethacin emulsion using biopolymer of Prunus avium


Department of Pharmacy, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttrakhand, India

Date of Web Publication21-Mar-2012

Correspondence Address:
Shivangi Verma
Department of Pharmacy, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttrakhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94125

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   Abstract 

The aim of the investigation was to formulate Indomethacin Emulsion using Bio-polymer as Emulsifier. Different batches of emulsions were prepared by varying concentration of biopolymer prunus avium. Based evaluation of the prepared polymers, a conclusion can be drawn that in the Prunus avium bio-material can serve as a promising film forming agent for formulating various drug.

Keywords: Emulsion, indomethacin, bio polymer, Prunus avium


How to cite this article:
Verma S, Dabral P, Rana V, Upadhaya K, Bhardwaj. Formulation of indomethacin emulsion using biopolymer of Prunus avium. J Pharm Bioall Sci 2012;4, Suppl S1:23-4

How to cite this URL:
Verma S, Dabral P, Rana V, Upadhaya K, Bhardwaj. Formulation of indomethacin emulsion using biopolymer of Prunus avium. J Pharm Bioall Sci [serial online] 2012 [cited 2020 Jan 23];4, Suppl S1:23-4. Available from: http://www.jpbsonline.org/text.asp?2012/4/5/23/94125

Biopolymers are polymers that are biodegradable. The input materials for the production of these polymers may be either renewable (based on agricultural plant or animal products) or synthetic. Current and future developments in biodegradable polymers and renewable input materials focus relate mainly to the scaling-up of production and improvement of product properties. Larger scale production will increase availability and reduce prices. Prunus is a genus of trees and shrubs, including the plums, cherries, peaches, apricots and almonds. The biopolymer derived from prunus avium has found various applications in pharmaceuticals.


   Materials and Methods Top


To formulate indomethacin emulsion using bio-polymer as emulsifier.

Preparation method

2 ml bio-polymer was taken in a test tube than 10 ml of accetone was added to it with continuous shaking. 10 mg of Indomethacin drug was added in the 5 ml of soyabeen oil, 2.5 ml of water and different concentration of polymer in the morter pastle. To this mixture 10% pectin was added and was vigoursly shacked.

The different formulations containing different proportions of ingredients from which films were formed. Release of drug was carried out using egg shell membrane.

Egg shell membrane was separated by using conc. hydrochloric acid. Then measured quantity of film (i.e.1 cm) was attached to membrane. The egg shell membrane with drug (Indomethacin) was tied around one end of an open tube. Further the membrane with drug was dipped in the phosphate buffer solution (pH-2.3). Then after every 30 min. 5 ml solution was taken and 5 ml buffer solution was added to make the volume, the reading was taken until 3 hrs and than it was observed spectrophotometrically. Same procedure was repeated for different formulated films of Indomethacin emulsion with phosphate buffer (pH-2.3) [Figure 1].
Figure 1: Indomethacin release using bio polymer. Release of drug through egg shell membrane

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   Results and Discussions Top


The stable formulation was successfully prepared using different concentration of biopolymer. [Table 1] shows the three formulations prepared using different concentration of biopolymer as an emulsifier. The results of evaluation parameters and in vitro diffusion studies were also suggests the formulation F3 shows the better performance than the other formulations.
Table 1: Formulations

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   Conclusions Top


From above three formulations, the best formulation was F3. Based on the above study a conclusion was drawn that in the Prunus avium bio-material can serve as a promising film forming agent for formulating various drug. [1],[2]

 
   References Top

1.Kandavilli S, Nair V, Panchagnula R. Polymers in transdermal drug delivery systems. Pharma Technol 2002. p. 62-78.  Back to cited text no. 1
    
2.Guy RH. Current status and future prospects of transdermal drug delivery, Pharm Res 1996;13:1765-9.  Back to cited text no. 2
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]



 

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