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 Table of Contents  
ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 25-26  

Formulation and evaluation of rifampicin sustained release tablets using juice of Citrus limetta as bio-retardant


Department of Pharmacy, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand, India

Date of Web Publication21-Mar-2012

Correspondence Address:
K Pawan Gaur
Department of Pharmacy, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94126

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   Abstract 

The advantages of biopolymers over synthetic polymers are low cost, natural origin, free from side effects, biocompatible, bio-acceptable, environmental friendly processing, local availability, better patient tolerance as well as public acceptance. Sustained release tablets containing rifampicin was prepared by adding 100 mg polymer and 50 mg Drug and Granules. Same procedure was followed with 3% and 5% of polymer for preparation of sustained release tablets. Additional Tablets of 100 mg, 200 mg and 400 mg were prepared using 5% of the polymer. The results indicated that the selected biopolymer had a good release retardant property thus it can be concluded that the selected biopolymer can be utilized as low cost natural biocompatible and biodegradable agent.

Keywords: Citrus limetta , sustained release granulation, rifampicin, lactose


How to cite this article:
Gaur K P, Soam K, Gupta S K, Dabral P. Formulation and evaluation of rifampicin sustained release tablets using juice of Citrus limetta as bio-retardant. J Pharm Bioall Sci 2012;4, Suppl S1:25-6

How to cite this URL:
Gaur K P, Soam K, Gupta S K, Dabral P. Formulation and evaluation of rifampicin sustained release tablets using juice of Citrus limetta as bio-retardant. J Pharm Bioall Sci [serial online] 2012 [cited 2019 Sep 23];4, Suppl S1:25-6. Available from: http://www.jpbsonline.org/text.asp?2012/4/5/25/94126

Sustained release (SR) dosage forms are the drug delivery systems designed to achieve a prolonged therapeutic effect continuously by releasing medication over an extended period of time after administration of a single dose. They offer several advantages such as reduced frequency of dosing, enhanced patient compliance, improved therapeutic efficacy and reduced side effects. The advantages of biopolymers over synthetic polymers are low cost, natural origin, free from side effects, biocompatible, bio-acceptable, environmental friendly processing, local availability, better patient tolerance as well as public acceptance. They improve the national economy by providing inexpensive formulations to people, using locally available materials. [1]


   Materials and Methods Top


The fruits of Citrus limetta were taken and their outer covering was removed. The juice was extracted from the fruits and subjected to centrifuge. In the supernatant equal amount of ethanol was added and kept it in refrigerator for 30 min, then centrifuge the mixture and dry at room temp. CaCl 2 washing was done and after drying resize it with sieve #16. Fine powder was collected as Bio-polymer.

For the Granulation 1%, 3% and 5% solution of polymer was made in Distilled water and appropriate amount of Lactose (10 gm) was added to it. Then Granules were subjected to resize with sieve#16. Before compression of granules, 2%Talc and 2% fine powder were mixed well. For the preparation of sustained release tablets containing rifampicin was prepared by adding 100 mg polymer, 50 mg drug and granules. Same procedure was followed with 3% and 5% of polymer for preparation of sustained release tablets. Additional tablets of 100 mg, 200 mg and 400 mg were prepared using 5% concentration of the polymer. The prepared was evaluated for its performance and in vitro release.


   Results and Discussion Top


The biopolymer from citrus limetta was isolated and evaluated for release retardant property in sustained release tablet. Among the three formulations, FM-3 shows Hardness of 5moh, Friability of (.90), Weight variation of (5.0). It had T50% and T 80% of 1.34 hrs and 2.52 hrs at pH (1.2) respectively. Hence this Formulation was the Best among the three prepared formulations [Figure 1], [Figure 2] and [Table 1].
Figure 1: In-vitro release study for tablets prepared by using 5% conc. of polymer

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Figure 2: Graph for cumulative % drug release vs time of rifampicin at pH (1.2)

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Table 1: Observation Table for release study

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   Conclusion Top


The results indicated that the selected biopolymer had a good release retardant property thus it can be concluded that the selected biopolymer can be utilized as low cost natural biocompatible and biodegradable agent.

 
   References Top

1.Albery WJ, Hadgraft J. Percutaneous absorption: In vivo experiments. J Pharm Pharmacol 1979;31:140-7.  Back to cited text no. 1
    


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1]


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