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ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 27-28  

Formulation and evaluation of indomethacin biomicroparticles


Department of Pharmacy, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand, India

Date of Web Publication21-Mar-2012

Correspondence Address:
Sudeep Gupta
Department of Pharmacy, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94127

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   Abstract 

Indomethacin microparticles prepared by extraction of bio polymer from arachis hypogen. in vitro drug release study was carried out through egg shell membrane for 3 hrs and analyzed sample by UV spectroscopy at 320 nm. A novel bio membrane from arachis hypogen was isolated by simplify economical process. The % yield was found to be 80% and particle range was 32-65 μm.

Keywords: Microparticles, biomicroparticles, indomethacin


How to cite this article:
Gupta S, Gaur P, Soam K, Suyal R, Rana V, Dabral P. Formulation and evaluation of indomethacin biomicroparticles. J Pharm Bioall Sci 2012;4, Suppl S1:27-8

How to cite this URL:
Gupta S, Gaur P, Soam K, Suyal R, Rana V, Dabral P. Formulation and evaluation of indomethacin biomicroparticles. J Pharm Bioall Sci [serial online] 2012 [cited 2020 Sep 21];4, Suppl S1:27-8. Available from: http://www.jpbsonline.org/text.asp?2012/4/5/27/94127

Microparticles are particles between 0.1 and 100 ΅m in size. Controlled release dosage forms cover a wide range of prolonged action formulations, which provide continuous release of their active ingredients at a predetermined rate and predetermined time. [1] Indometacin is a NSAIDs commonly used to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins.


   Materials and Methods Top


Extraction of bio-polymer from Arachis hypogea

The outer layer of seeds was removed and fried until they become light brown. Fried seeds subjected to Grinding by adding sufficient water to it for 30-45 min. The mixture was filtered through muslin cloth and pea nut milk is separated. Solvent {Ethanol: Acetone (1:1)} was added to the milk and then subjected to refrigeration for 30 min. Mixture was filtered and washed with N-hexane. Dried micro particles were then subjected to Dessicator for drying. Dried micro particles were collected as bio-polymer.

Preparation

Indomethacin was dissolved in Chloroform and bio-polymer solution was prepared by adding water to it. The Drug solution was added to bio-material solution and mixed by Magnetic stirrer until emulsion is formed. Then formed emulsion is subjected to evaporation and dried micro particles were collected.

In-vitro drug release

Release of drug through egg shell membrane: Egg shell membrane was separated using con. The egg shell membrane attached to the tube. Measured quantity of micro particles was transferred and the tube was dipped in the phosphate buffer (pH-1.2). After every 30 min. for 2 hrs, 5 ml solution was withdrawal and 5 ml buffer solution was added to make the volume. It was observed spectrophotometrically. Same procedure was repeated for different formulated films of aceclofenac with phosphate buffer (pH-7.4) [Figure 1], [Figure 2].
Figure 1: % Cummulative release vs time in pH 1.2

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Figure 2: % Cummulative release vs time in pH 7.4

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Dissolution studies

The Dissolution studies were perform and subjecting it for dissolution for 3 hrs and analyze the samples by UV Spectrophotometer at 320 nm.


   Result and Discussion Top


A Novel Bio simplified Economical process. The yield was 1% per 100 gms. Five different formulations were formulated using various proportion of Bio loaded Sustained release Bio-micro particles was performed. The result shows the Zero among the five formulations FG 32.65 Micrometers. It had T50% and T 80% of 1.56 hrs and 2.45 hr Formulation FG-5 shows Percentage yield T50% and T80% of 1.62 hrs and 2.61 hrs at Hence these Two Formulations are the Best among the five prepared formulations.

 
   References Top

1.Albery WJ, Hadgraft J. Percutaneous absorption: In vivo experiments. J Pharm Pharmacol 1979;31:140-7.  Back to cited text no. 1
    


    Figures

  [Figure 1], [Figure 2]



 

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