Journal of Pharmacy And Bioallied Sciences
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ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 46-47

Preparation and evaluation of Levosalbutamol sulphate chitosan microsphere for the treatment of asthma


Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat, India

Correspondence Address:
D Dinal Patel
Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94139

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Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In present work, mucoadhesive chitosan microspheres of Levosalbutamol sulphate were prepared by Spray drying method. Formulations were characterized for various physicochemical attributes size, encapsulation efficiency, swelling ability, in vitro release study and mucoadhesion study by rat ileum. Through these parameters we conclude that the batch B 2 was found to be best mainly by mucoadhesion study and in vitro drug release. Mucoadhesion was found to be increased with incresed concentration of polymer and visa versa in case of drug release. Batch B 3 had also similar results with that of Batch B 2 . That's why here Batch B 2 was said to be the best batch with less polymeric content as compare to Batch B 3 .


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