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ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 62-63

Dissolution enhancement of albendazole through nanocrystal formulation


Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Anand, Gujarat

Correspondence Address:
D Krishna Koradia
Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Anand, Gujarat

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94141

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Albendazole, a BCS class II drug, has poor dissolution characteristic. In order to enhance dissolution nanocrystals were prepared by antisolvent precipitation process using PVP K-30(0.05%,0.1%,0.2%,0.4%) as stabilizer. The process was optimized in terms of concentration of stabilizer(PVP K 30) in order to enhance dissolution and obtain stable particles with a small mean particle size. Nanocrystals were characterized with respect to particle size, in vitro dissolution and X-ray diffraction pattern. Decrease in particle size of nanocrystals was observed with increase in concentration of stabilizer. Dissolution of nanocrystals also improved with increase in concentration of PVP K-30. Crystalline state evaluation before and following particle size reduction was conducted through XRD to denote any possible transformation to an amorphous state during process.


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