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ORIGINAL/BRIEF
Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 86-87

Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design


Nootan Pharmacy College, Visnagar, India

Correspondence Address:
Dipil Patel
Nootan Pharmacy College, Visnagar
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.94150

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The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X1), superdisintigrant (sodium starch glycolate, X2), and direct compression aid (spray dried lactose, X3). Tablets were characterized for weight variation, thickness, disintegration time (Y1) and hardness (Y2). Good correlation between the predicted values and experimental data of the optimized formulation methodology in optimizing fast disintegrating tablets using pullulan as a diluent.


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