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SHORT COMMUNICATION
Year : 2013  |  Volume : 5  |  Issue : 2  |  Page : 162-165

Nanoparticles laden in situ gel for sustained ocular drug delivery


1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
2 Department of Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, Ministry of Defence, New Delhi, India

Correspondence Address:
Mohammed Aqil
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi
India
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Source of Support: Dr. Himanshu Gupta was recipient of Senior Research Fellowship of Council of Scientific and Industrial Research (Government of India), New Delhi, India, Conflict of Interest: None


DOI: 10.4103/0975-7406.111824

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Proper availability of drug on to corneal surface is a challenging task. However, due to ocular physiological barriers, conventional eye drops display poor ocular bioavailability of drugs (< 1%). To improve precorneal residence time and ocular penetration, earlier our group developed and evaluated in situ gel and nanoparticles for ocular delivery. In interest to evaluate the combined effect of in situ gel and nanoparticles on ocular retention, we combined them. We are the first to term this combination as "nanoparticle laden in situ gel", that is, poly lactic co glycolic acid nanoparticle incorporated in chitosan in situ gel for sparfloxacin ophthalmic delivery. The formulation was tested for various physicochemical properties. It showed gelation pH near pH 7.2. The observation of acquired gamma camera images showed good retention over the entire precorneal area for sparfloxacin nanoparticle laden in situ gel (SNG) as compared to marketed formulation. SNG formulation cleared at a very slow rate and remained at corneal surface for longer duration as no radioactivity was observed in systemic circulation. The developed formulation was found to be better in combination and can go up to the clinical evaluation and application.


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