Journal of Pharmacy And Bioallied Sciences
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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 4  |  Page : 314-317

Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry


Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Near Aravind Baug, Mehsana, Gujarat, India

Correspondence Address:
Amit V Patel
Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Near Aravind Baug, Mehsana, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.120079

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Aim: To develop a simple, accurate, sensitive, rapid and precise method for the determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form. Material and Methods: The method employs wavelength detection and determination of galantamine hydrobromide at excitation wavelength 282 nm and emission wavelength 607 nm in a solution of simple distilled water. Result and Conclusion: The method was found to be linear in the range of 2-14 μg/ml having r2 = 0.9999. The mean accuracy was found to be 98.12% to 99.67%. The intraday and interday precision was found to be 0.18-0.35% and 0.13-0.46%, respectively. The limit of detection was found to be 0.29 μg/ml. The limit of quantification was found to be 0.89 μg/ml. The method was successfully applied for the determination of galantamine hydrobromide in bulk drug as well as pharmaceutical dosage form.


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