Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 1584  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


REVIEW ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 3  |  Page : 139-150

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues


1 Department of Pharmaceutics, J. C. D. M. College of Pharmacy, Sirsa, Haryana, India
2 Department of Pharmaceutical Chemistry, J. C. D. M. College of Pharmacy, Sirsa, Haryana, India

Correspondence Address:
Deepti Pandita
Department of Pharmaceutics, J. C. D. M. College of Pharmacy, Sirsa, Haryana
India
Login to access the Email id

Source of Support: The Science and Engineering Research Board, Department of Science and Technology, Government of India is acknowledged for funding through the project SR/FT/LS.145/2011, Conflict of Interest: None


DOI: 10.4103/0975-7406.130965

Rights and Permissions

Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed9326    
    Printed170    
    Emailed2    
    PDF Downloaded299    
    Comments [Add]    
    Cited by others 53    

Recommend this journal