|Year : 2015 | Volume
| Issue : 3 | Page : 181-187
The use of psychotropic substances among students: The prevalence, factor association, and abuse
Che Fadhilah bt Mamat1, Shazia Qasim Jamshed1, Tarek El Syed1, Tahir Mehmood Khan2, Noordin Othman3, Abdul Kareem Al-Shami1, Syahrir Bin Zaini1, Mohammad Jamshed Siddiqui4
1 Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
2 Department of Pharmacy, Monash University, Sunway Campus, Kuala Lumpur, Malaysia
3 Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Almadinah Almunawwarah, Kingdom of Saudi Arabia
4 Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Malaysia
|Date of Submission||28-Dec-2014|
|Date of Decision||18-Feb-2015|
|Date of Acceptance||21-Apr-2015|
|Date of Web Publication||6-Jul-2015|
Mohammad Jamshed Siddiqui
Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan
Source of Support: None, Conflict of Interest: None
| Abstract|| |
This detailed review analyzed the previously published studies related to the prevalence of psychotropic substances use, associated factors, and the misuse of the psychotropics among students. A comprehensive literature search covering six databases was performed. References from published articles and reports were extracted. This helped in identifying the available information on the use of psychotropic drugs. A total of 16 articles were included in this review. There is an upsurge of using psychotropics with the preceding years. More students are exposed to the risk of using psychotropic substances due to the multiple factors like stress, increased academic workload, etc. The misuse is found to be common with prescribed psychotropic substances. Students need to be aware of the bad outcomes of using psychotropic substances. Participation of every stakeholder to curb this menace needs to be emphasized. More extensive studies are required to know about the increasing prevalence, factors, and misuse of psychotropics.
Keywords: Psychotropic, students, misuse, prevalence
|How to cite this article:|
Mamat Cb, Jamshed SQ, El Syed T, Khan TM, Othman N, Al-Shami AK, Zaini SB, Siddiqui MJ. The use of psychotropic substances among students: The prevalence, factor association, and abuse. J Pharm Bioall Sci 2015;7:181-7
|How to cite this URL:|
Mamat Cb, Jamshed SQ, El Syed T, Khan TM, Othman N, Al-Shami AK, Zaini SB, Siddiqui MJ. The use of psychotropic substances among students: The prevalence, factor association, and abuse. J Pharm Bioall Sci [serial online] 2015 [cited 2020 Mar 30];7:181-7. Available from: http://www.jpbsonline.org/text.asp?2015/7/3/181/160011
Since past several decades, the use of psychotropic substances is considered an important issue with significant morbidity and mortality.  A psychotropic drug can be defined as any drug capable of affecting the mind, emotions, and behavior.  Globally, there are various types of psychotropic drugs or substances used. In this review, most commonly used psychotropic substances are categorized within three classes such as benzodiazepines, stimulants, and opiates.  The second and third class are cannabis and cocaine and alcohol, tobacco, and kola nut, respectively. 
The trend of using psychotropic substances is increased gradually.  Therefore, a mere thoughtfulness of the contributory factors toward the psychotropic use, their prevalence, and the misuse is the gist of the current review.
| Methods|| |
A literature search was performed during the period of September 2012 to October 2013 to identify published studies related to the use of psychotropic medications among students. The articles which emphasized on the usage, prevalence, gender differences, associating factors, and misuse of psychotropic medications were included. Studies not encompassing students and had respondents >30 years of age were fitted into the exclusion criterion. The retrieved literature was abstracted using a standardized data abstraction form in a table format containing most of the elements presented in [Table 1].
|Table 1: A summary of the studies included in the review investigating the use of psychoactive drug among students|
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The search strategy involved using Boolean operators for the combination of following terms: Psychotropic, drugs, medicines, medication misuse, and students. The search was limited to full paper articles published in English from 1998 to October 2013.
Electronic databases included in the search were EBSCOhost, Science Direct, Springer Link, Proquest, CINAHL Plus with Full Text, and Google Scholar. Identified studies were arranged chronologically starting from the 2003 to 2013 [Figure 1].
The three main objectives of this review were prevalence the usage of psychotropic medications by examining the trend of use, factors associated with the usage of psychotropic substances, and as well as the misuse of any psychotropic drugs.
| Results|| |
From 45 titles and abstracts which were identified from the above-mentioned databases, only 16 titles were used in this literature review. The other 28 titles and abstracts did not meet the objectives of this review. Only one is excluded for having <20 numbers of respondents. For all the 16 titles full texts were retrieved and divided into three categories, that is, the usage prevalence and rate, associated factors, and the misuse of psychotropic drugs.
The rates and prevalence of the usage of psychotropics
According to Stone and Merlo, there are higher rates of psychiatric medication misuse when compared to the rates of medical use.  Saddock and Saddock reported that illicit substance use in the youth population is more prevalent than any other age groups in the society.  In Malaysia, the usage of psychotropic drugs is increased mainly due to western influence, rapid urbanization, and industrial exposure parallel with the rapid progression of the Malaysia from a developing nation to a transitional economy.  In this cross-sectional study, of 200 Malaysian university students, the prevalence of using sleeping pills was found to be high. 
Soldera et al. studied the prevalence and associated social factors among the high school students of both the public and private schools.  The study was done on 2287 elementary and high school students. There were some factors identified as protectors and facilitators. Religious knowledge during childhood was identified as protector whereas facilitating factors promoting heavy use of legal and illegal drugs were financial assets, socialization patterns with friends, and deteriorated family environment.  On the contrary, Lambert and his associates focused their study on the prevalence of psychoactive drug use among the medical students. It was a cross-sectional study design with a final sample of 1.054 medical students which reported the use in medical students is not exceptionally extensive in comparison to the rates reported for other developed countries.  Alcohol abuse, cocaine lifetime use, and inhalant lifetime use were more pronounced among male students of higher income groups whereas tranquilizer use was more prominent among females. 
The work of Ryan and associates explored the prevalence of psychotropic medication for the treatment of students with emotional behavior. A total of 137 medication records from three different nonpublic residential schools in United States were reviewed. Anti-psychotics (n = 57, 41.6%), selective serotonin reuptake inhibitor (n = 41, 29.9%), mood stabilizers (n = 39, 28.5%), and last but not the least the stimulants were prescribed (n = 18, 28.5%). 
Rosvold conducted a survey in one of the universities in Norway, which aimed to analyze the medicine use in general. In a survey executed with 604 students under the age of 30 years old, it was found that the use of psychotropic drugs was still one of the favorite drug categories consumed by females, most likely because female students were found to be more stressed. 
A study conducted by Azaiza et al. in the Israel region in 2008 used self-reported questionnaires as a tool to collect the pattern of use of psychotropic substances among Arab secondary school students. In a sample of 2944 students, 14% of the participants reported to have used tobacco in the past year whereas 17% admitted that they had consumed more than one type of alcoholic beverages. The rate for all types of illegal uses was 12%. More male students were identified to use psychoactive substances than their female counterparts; that is, in the use of cigarette and cannabis. 
Three included studies executed in the year 2009 from USA, Taiwan, and Nigeria reported alcohol, tobacco, marijuana, cocaine, relaxants, amphetamines, barbiturates, and opiates categories.  Stolberg in an African-American based study reported that regardless of gender more than three-fourth of the respondents reported to "ever use any of the drugs" on the other hand, Chen et al. studied about the use of ecstasy and other psychoactive substances among the adolescents in Taiwan. In this national survey that was done consecutively from 2004 to 2006 with the involvement of a bigger sample; that is, 18,232 students in 2004, 17,986 in 2005, and 17,864 in 2006 Ecstasy and ketamine appeared the most commonly used illegal drugs. Majority of the ecstasy users were involved in poly-drug usage.  For Nigeria, the study was done by focusing on the Almajiri group of students. Almajiri are children that were sent away at an early age by their parents to get religious knowledge from their teachers. They live together with their friends independently. Living a life of street children, usually these students were asked to beg in the street and do some menial jobs such as cleaning people shoes, selling paper, and others to support their daily needs. A cross-sectional survey was conducted with the involvement of 340 Almajiri male students. The prevalence of the drug use was 66.2%, and the most common substances used were stimulants, volatile solvents, cigarettes, and cannabis  highlighting the high usage of the psychotropic drug among teenage students.
Studies on the use of psychotropic drugs in Malaysia are limited. In the current review, one study was retrieved which emphasized on the prevalence of the sleeping pill use among students. With a 200 sample size study at the Management and Science University, Malaysia it reported the prevalence of sleeping pill use of about 7.5%.  A significant relationship was reported between sleeping pills to depression as well as their usage to induce sleeping by reading.
In one of the Nigerian studies by Famuyiwa et al. their focus was on adolescents of the metropolitan Lagos, Nigeria. A total of 4286 school pupils were assessed for the use of 14 types of psychotropic drugs. For all of them, the lifetime prevalence was found out to be 61.8% and the use in the past 1 year was 32.2%. The most common or highest used drug both in "lifetime prevalence" and in the "past year prevalence" was mild stimulants which were coffee (61.8%), kola nut (42.6%), and alcohol (32.2%). 
Contributory factors toward the usage
Carroll et al. studied the pattern and knowledge of the nonmedical use of stimulants among college students majoring in arts. A sample of 347 undergraduates was recruited to assess their knowledge on the "stimulant use." More than half of the total students had peers who used nonprescription stimulants. Interestingly, there were students visiting the physicians to get the medication for ADHD; although they did not have the disease. More than half of the respondents knew people who sold stimulants to students. 
Chau et al. published a study in 2008, to identify the factors contributing to the usage of these drugs. The study was conducted on a sample of 1257 people aged 18-29 randomly selected in North-Eastern France by means of a postal survey. The disparity in socioeconomic status imparts great influences in this matter.  Interestingly, it was found out that housewives and students are at higher risk for psychotropic drug use than an unemployed young adult. Other stressors such as financial problem among students and academic pressures and their consequences on the social life also contribute to the high possibility of using psychotropic medications.
A study by Eickenhorst et al. in 2012 also reported that the leading motives of German university students was to use any class of psychotropic drugs for a neuro-enhancement effect, thereby expecting to improve concentration.  In this web-based survey of 1324 undergraduate and postgraduate students large academic workload and the management of the high level of stress were found to be primary motivators of practicing neuro-enhancement. These findings are in parallel with many previously published studies. ,, Other potential motives were increased vigilance followed by enhanced cognitive performance.  A large percentage of respondents reported that the use of psychotropic drugs improve the concentration.
Misuse of the psychotropic drug from prescription
Many a times, it is necessary for the physician to prescribe the psychiatric medications as a treatment for students and often these then further misused and abused especially in the college campus.  It is estimated that for every three students taking the prescribed psychotropic medication, one of them will divert the actual usage of the medication for their own purposes.
Quintero et al. studied the prescription drug misuse among the college students and reported out that from a total of 238 lifetime episodes of misuses, 56 different prescription drugs approximately equals to the five episode of prescription misuse per respondent. In this study, 52 college students at a public university in US were interviewed. From the findings, the psychotropic drugs were found out to be most commonly and widely misused. It included opioid analgesic, benzodiazepine such as diazepam, alprazolam, and also stimulants like methylphenidate.  Most of the students got the drugs from the prescription that the physician prescribes to them.
Stone and Merlo in 2011 reported about the misuse of psychotropic medication in college students which resulted in high rates of drug misuse compared to rates of medical use. This study represented a sample of 383 students recruited on campus or via an online class of different ethnicities and background.  In other words, the sample was reflective of overall students' population. The same pattern of usage was also seen in a study in one of the universities in Lebanon in which they found out the rate of nonmedical is half of the actual activity of the drug as psychotherapeutics. Medical and nonmedical lifetime usage rates were pain, anxiety, insomnia, and stimulants. Ghandour et al. reported that 1 out of 5 person (20%) will divert the actual usage of the medication to their intended purposes such as help in sleeping or increasing alertness. The higher rate of misuse was observed more following the lifetime marijuana users and alcohol abusers. 
| Discussion|| |
Of all the articles reviewed, it can be summed up that the higher prevalence use of any psychotropic substance is alcohol usage. This is commonly shared by most of the previously published studies which do not only focus on just one type of psychotropic substance. The overall percentage of alcohol consumption is always more than 10% from the total percentage of all the substances tested. ,, This is not a surprising outcome since alcohol is one of the socially-acceptable psychotropic substance worldwide.  There are three studies in the current review that contravenes to each other from the gender perspectives. Females are found to use more psychotropic drugs in a sense to fight their depression as compared to male students.  This happens because of the mental stresses that usually occur to female, and they are more open to share with the physician or psychiatrist regarding their condition or problem. The ratio of psychotropic drug use among female to male is approximately 2:1 as shown in cross sectional studies that supported this basis. Most of them related to the usage of prescribed psychotropic drugs.  From another perspective, male students are found to be at the higher prevalence of the cannabis and tobacco and alcohol use. , It is reported that more males consume tobacco (30.2% vs. 21.9%) and alcohol abuse (12.5% vs. 3.3%) rather than females.  This is presumably due to the fact that the tobacco usage is extensive and is seen as one of the common habits in male, contributing to project their image of masculinity. On the contrary to both studies before, Stolberg did not find any difference of the usage of psychotropic substances in relation to gender. 
In general, there are many factors that contribute to the usage of the psychotropic medication. One of them is the usage related to the performance in studying processes. More students use the psychotropic drug in the form of stimulants in order to increase the concentration in learning as well as to have a longer period of studying by staying awake, , improvised academic performance  and make them more relaxed. 
Stress is also one of the factors that contribute to psychotropic drug taking behavior.  The elevation in the psychological distress is reported to be higher among university students as compared to the general population norm.  For example, a study done on the medical student in southern Brazil stated that the crescent workload and expectation in the academic life tend to put the student in more distressful situations and thus predisposing them to the consumption of psychotropic drugs. 
Other than that the usage of the psychotropic drugs is also increased due to environmental and social factors. Students that come from the unsuccessful family institutions are more prone to consume psychotropic drugs.  Both study from Chau et al. and Azaiza et al. supported this theory and highlighted the significant role of the family in modeling good children. Students that have a strong relationship with their parents and feel at ease with their family and friends are found out to be more protected against the usage of the drug. , Moreover, their obedience and respect toward their parents make them become aware of their responsibilities and prevent them from taking these type of habit-forming or addictive drugs.
In terms of individual religiosity, there is the low prevalence of usage among those students who had strong beliefs in their religions or the existence of GOD even when they had easy access to different psychotropic substances.  On the other hand, a higher rate of psychotropic substance usage is associated with the students with low religiosity.  Religiosity does not account only for Muslims such as in the case of "Almajiri" student but also for those who present to church regularly. 
The misuse of the psychotropic substance is also higher among the college students. Despite not having any problems or diseases related to the usage of psychotropic drugs, students still seek the physician; although they believed that they have no such diseases like ADHD.  McCabe et al. categorized this misuse as nonmedical usage of the drug and students often misuse this type of psychotropic substance due to their easy availability of the drugs or either getting from peers and family members with legitimate prescription. 
| Conclusion|| |
Globally, the usage of psychotropic drugs is evolving gradually. There is increased need of awareness on the psychotropic substances usage or consumption among the community. Awareness regarding its side effects, habit forming and/or addictive property and as well as interaction with other drugs need to be done especially among teenage and students. Moreover, it is pertinent that the enforcement policies regarding psychotropic substances might be improved to fulfill any loopholes in the regulation.
Last but not the least, there are some limitations in this review. This study does not really reflect the overall prevalence of use of the psychotropic drug for the whole population. This is due to the fact that different countries may practice difference types of regulation in drug prescription.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Galea S, Nandi A, Vlahov D. The social epidemiology of substance use. Epidemiol Rev 2004;26:36-52.
Saunders, Dorland, editor. Dorland's Pocket Medical Dictionary. 28 th
Odejide OA, Morakinyo J. Substance abuse and its socioeconomic consequences in Nigeria. International Journal of Mental Health and Addiction. Gulf, Kuwait: Proceedings of the Mental Health Care Practices; 2004.
Stone AM, Merlo LJ. Attitudes of college students toward mental illness stigma and the misuse of psychiatric medications. J Clin Psychiatry 2011;72:134-9.
Saddock BJ, Saddock VA. Kaplan and Saddock's Synopsis of Psyhiatry. 8 th
ed. Philapedhia: Lippincott Willian and Wilkin; 2003.
Al-Naggar RA, Isa ZM, Musa R. Prevalence and associated factors of sleeping pills use among students in a Malaysian university. ASEAN J Psychiatr 2010;11:171-9.
Soldera M, Dalgalarrondo P, Corrêa Filho HR, Silva CA. Use of psychotropics drugs among students: Prevalence and associated social factors. Rev Saude Publica 2004;38:277-83.
Lambert Passos SR, Alvarenga Americano do Brasil PE, Borges dos Santos MA, Costa de Aquino MT. Prevalence of psychoactive drug use among medical students in Rio de Janeiro. Soc Psychiatry Psychiatr Epidemiol 2006;41:989-96.
Ryan JB, Reid R, Gallagher K, Ellis C. Prevalence rates of psychotropic medications for students placed in residential facilities. Behav Disord 2008;33:99-107.
Rosvold EO. Self-reported use of medicines among university students in Oslo, Norway. Nor Epidemiol 2008;18:195-9.
Chen WJ, Fu TC, Ting TT, Huang WL, Tang GM, Hsiao CK, et al
. Use of ecstasy and other psychoactive substances among school-attending adolescents in Taiwan: National surveys 2004-2006. BMC Public Health 2009;9:27.
Abdulmalik J, Omigbodun O, Beida O, Adedokun B. Psychoactive substance use among children in informal religious schools (Almajiris
) in Northern Nigeria. Ment Health Relig Cult 2009;12:527-42.
Famuyiwa O, Aina OF, Bankole-Oki OM. Epidemiology of psychoactive drug use amongst adolescents in metropolitan Lagos, Nigeria. Eur Child Adolesc Psychiatry 2011;20:351-9.
Carroll BC, McLaughlin TJ, Blake DR. Patterns and knowledge of nonmedical use of stimulants among college students. Arch Pediatr Adolesc Med 2006;160:481-5.
Chau N, Baumann M, Falissard B, Choquet M; Lorhandicap Group. Social inequalities and correlates of psychotropic drug use among young adults: A population-based questionnaire study. Int J Equity Health 2008;7:3.
Eickenhorst P, Vitzthum K, Klapp BF, Groneberg D, Mache S. Neuroenhancement among German university students: Motives, expectations, and relationship with psychoactive lifestyle drugs. J Psychoactive Drugs 2012;44:418-27.
Quintero G, Peterson J, Young B. An exploratory study of socio-cultural factors contributing to prescription drug miuse among college students. J Drug Issues 2006;36:903-31.
Ghandour LA, El Sayed DS, Martins SS. Prevalence and patterns of commonly abused psychoactive prescription drugs in a sample of university students from Lebanon: An opportunity for cross-cultural comparisons. Drug Alcohol Depend 2012;121:110-7.
Azaiza F, Shoham M, Bar-Hamburger R, Abu-Asbeh K. Patterns of psychoactive substance use among Arab secondary school students in Israel. Subst Use Misuse 2008;43:1489-506.
Stolberg VB. Lack of gender differences in lifetime substance use reported among African-American urban community college students. J Ethn Subst Abuse 2009;8:70-98.
Baumann M, Spitz E, Guillemin F, Ravaud JF, Choquet M, Falissard B, et al
. Associations of social and material deprivation with tobacco, alcohol, and psychotropic drug use, and gender: A population-based study. Int J Health Geogr 2007;6:50.
Stolberg VB. Lack of gender differences in lifetime substance use reported among African-American urban community college students. J Ethn Subst Abuse 2009;8:70-98.
Boniatti MM, Zubaran C, Panarotto D, Delazeri GJ, Tirello JL, Feldens Mde O, et al
. The use of psychoactive substances among medical students in southern Brazil. Drug Alcohol Rev 2007;26:279-85.
Adlaf EM, Gliksman L, Demers A, Newton-Taylor B. The prevalence of elevated psychological distress among Canadian undergraduates: Findings from the 1998 Canadian Campus Survey. J Am Coll Health 2001;50:67-72.
McCabe SE, Teter CJ, Boyd CJ, Knight JR, Wechsler H. Nonmedical use of prescription opioids among U.S. college students: Prevalence and correlates from a national survey. Addict Behav 2005;30:789-805.
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