Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 596  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


DENTAL SCIENCE - ORIGINAL ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 6  |  Page : 672-676

Evaluation of transcription factor that regulates T helper 17 and regulatory T cells function in periodontal health and disease


1 Department of Periodontics, CSI College of Dental Science and Research, Madurai, Tamil Nadu, India
2 Department of Periodontics, AB Shetty Memorial and Institute of Dental Science, Veralakatte, Mangalore, Karnataka, India
3 Department of Periodontics, Ragas Dental College, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. B Karthikeyan
Department of Periodontics, CSI College of Dental Science and Research, Madurai, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.163602

Rights and Permissions

Background: The differentiation of naοve T helper (Th) cells towards Th17 and regulatory T cells (Treg) is regulated by the transcription factors retinoic acid related orphan receptor gamma transcription (RORYt) and Forkhead box p3 (Foxp3), respectively. An imbalance in the activity of these transcription factors could result in the dysregulation of Th17/Treg response. Materials and Methods: Total RNA was isolated from gingival tissue obtained from 10 patients, each from periodontally healthy and diseased groups. The gene expression of RORYt and Foxp3 was measured by real-time reverse transcription polymerization chain reaction using total RNA isolates from gingival tissues group when compared to the healthy group, while Foxp3 demonstrated a 6.68 ΁ 0.03 fold decrease of expression in diseased group when compared to healthy group. Conclusion: Our results indicate a functional imbalance in the Th17/Treg response in periodontal disease group when compared to the periodontally healthy group.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1160    
    Printed20    
    Emailed0    
    PDF Downloaded33    
    Comments [Add]    
    Cited by others 2    

Recommend this journal