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LETTER
Year : 2017  |  Volume : 9  |  Issue : 2  |  Page : 152  

Pregabalin and uremic pruritus


Department of Neurology, M. G. Hospital, Dr. S. N. Medical College, Jodhpur, Rajasthan, India

Date of Web Publication23-Jun-2017

Correspondence Address:
Khichar Purnaram Shubhakaran
Department of Neurology, M. G. Hospital, Dr. S. N. Medical College, Jodhpur, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.179423

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How to cite this article:
Shubhakaran KP. Pregabalin and uremic pruritus. J Pharm Bioall Sci 2017;9:152

How to cite this URL:
Shubhakaran KP. Pregabalin and uremic pruritus. J Pharm Bioall Sci [serial online] 2017 [cited 2020 Sep 19];9:152. Available from: http://www.jpbsonline.org/text.asp?2017/9/2/152/179423

Sir,

I read an interesting article entitled, “effectiveness of posthemodialysis administration of pregabalin (75 mg) in treatment resistance uremia pruritus” by Khan et al., which was quite informative.[1] Here, I would like to share the relevant literature.

Earlier in a study in 2012, Rayner et al. have shown the efficacy of gabapentin and pregabalin. They also observed that the patients who intolerated gabapentin could tolerate pregabalin very well.[2] Pregabalin has been demonstrated to have excellent response in one earlier small-scale study on twelve patients and response was dramatic. They also observed that the pregabalin should be gradually build-up to avoid side effects.[3] In an another randomized placebo-controlled study and comparison with ondensetron, they found excellent response with pregabalin on 62 patients.[4]

Pregabalin is also effective in restless leg syndrome which is frequent in uraemia, it has less tendency to develop hypotension, impotency, weight gain better dosing profile in comparison to gabapentin, less costlier than lamotrigine, better side effect than doxepin, amitriptiline, nortriptyline, and paroxitin, so pregabalin may be a promising drug for itching in general and uraemic pruritis in particular. In coming future, of course, further data are needed to strong these promises.[5]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Khan TM, Aziz A, Suleiman AK. Effectiveness of posthemodialysis administration of pregabalin (75 mg) in treatment resistance uremia pruritus. J Pharm Bioallied Sci 2016;8:74-6.  Back to cited text no. 1
[PUBMED]    
2.
Rayner H, Baharani J, Smith S, Suresh V, Dasgupta I. Uraemic pruritus: Relief of itching by gabapentin and pregabalin. Nephron Clin Pract 2012;122:75-9.  Back to cited text no. 2
[PUBMED]    
3.
Shavit L, Grenader T, Lifschitz M, Slotki I. Use of pregabalin in the management of chronic uremic pruritus. J Pain Symptom Manage 2013;45:776-81.  Back to cited text no. 3
[PUBMED]    
4.
Yue J, Jiao S, Xiao Y, Ren W, Zhao T, Meng J. Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: A prospective, randomized, double-blind study. Int Urol Nephrol 2015;47:161-7.  Back to cited text no. 4
[PUBMED]    
5.
Conaglen HM, Conaglen JV. Drug-induced sexual dysfunction in men and women. Aust Prescr 2013;36:42-5.  Back to cited text no. 5
    




 

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