|Year : 2018 | Volume
| Issue : 4 | Page : 181-191
A review of the phytochemical and pharmacological characteristics of Moringa oleifera
Ayon Bhattacharya1, Prashant Tiwari2, Pratap K Sahu2, Sanjay Kumar3
1 Department of Pharmacology, KPC Medical College, West Bengal University of Health Sciences, Kolkata, West Bengal, India
2 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (SOA) University, Bhubaneswar, Orissa, India
3 Department of Pharmacology, GSL Medical College, Rajahmundry, Andhra Pradesh, India
|Date of Web Publication||23-Nov-2018|
Dr. Sanjay Kumar
Department of Pharmacology, GSL Medical College, Rajahmundry, Andhra Pradesh
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Moringa oleifera is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have shown the ability of this plant to exhibit analgesic, anti-inflammatory, antipyretic, anticancer, antioxidant, nootropic, hepatoprotective, gastroprotective, anti-ulcer, cardiovascular, anti-obesity, antiepileptic, antiasthmatic, antidiabetic, anti-urolithiatic, diuretic, local anesthetic, anti-allergic, anthelmintic, wound healing, antimicrobial, immunomodulatory, and antidiarrheal properties. This review is a comprehensive summary of the phytochemical and pharmacological activities as well as the traditional and therapeutic uses of this plant. M. oleifera has wide traditional and pharmacological uses in various pathophysiological conditions. We will review the various properties of M. oleifera (drumstick tree) and focus on its various medicinal properties. We think that it is an attractive subject for further experimental and clinical investigations.
Keywords: Moringa oleifera, pharmacological actions, phytochemistry
|How to cite this article:|
Bhattacharya A, Tiwari P, Sahu PK, Kumar S. A review of the phytochemical and pharmacological characteristics of Moringa oleifera. J Pharm Bioall Sci 2018;10:181-91
|How to cite this URL:|
Bhattacharya A, Tiwari P, Sahu PK, Kumar S. A review of the phytochemical and pharmacological characteristics of Moringa oleifera. J Pharm Bioall Sci [serial online] 2018 [cited 2019 Jan 18];10:181-91. Available from: http://www.jpbsonline.org/text.asp?2018/10/4/181/245904
| Introduction|| |
Moringa oleifera (MO), also known as drumstick tree, is indigenous to South Asia, mainly in foothills of Himalayas, India, and it has been grown and naturalized in other countries such as Afghanistan, Nepal, Bangladesh, Sri Lanka, South and Central America, West Indies, Philippines, and Cambodia.,It is short, easy to cultivate, grows quickly, and does not shed its leaves in dry season, and its leaves are highly nutritious and rich in amino acids, vitamins, minerals, and natural antioxidants.,,,, This was mentioned 5000 years ago in Charaka Samhita, and is well known in African folk medicine. This review focuses on the phytochemistry and pharmacological activities of this plant.
| Phytochemistry|| |
A pictorial depiction of MO is shown in [Figure 1], and worldwide distribution of MO is shown in [Figure 2]. It is a storehouse of ingredients, among which major ones are carotenoids, tocopherols (α, γ, δ), flavonoids, phenolic acids,,folate, polyunsaturated fatty acids, and various minerals. A list of some important phytoconstituents and their structures is given in [Table 2]. Gas chromatography–mass spectrometry study of the plant’s leaf revealed a total of 35 compounds; important compounds isolated were n-hexadecanoic acid, tetradecanoic acid, cis-vaccenic acid, octadecanoic acid, palmitoyl chloride, beta-l-rhamnofuranoside, 5-O- acetyl-thio-octyl, gamma-sitosterol, and pregna-7- diene-3-ol-20-one. E-lutein was found to be the most abundant carotenoid found in leafage. The plant’s radicle contains 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate and benzylglucosinolate. Spirochin and anthonine found in roots show bactericidal activity. Beta-sitosterone, vanillin, 4-hydroxymellein, β-sitosterol, and octacosanoic acid are found in the peduncle of the plant, and its crust is composed of 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate., ,
|Table 2: Structures of some important phytoconstituents of Moringa oleifera|
Click here to view
Its stem contains alkaloids (moringine and moringinine), 4-hydroxymellein, octacosanoic acid, and β-sitosterol.,Whole gum exudate contains l-rhamnose, d-glucuronic acid, l-arabinose, d-mannose, d-xylose, and d-galactose. Another important constituent present in gum is leucodelphinidin-3-O-B-D-galactopuranosy (1- >4)-O-B-D-glucopyranoside.,
Flowers contain sucrose, amino acids, alkaloids, and flavonoids, such as rhamnetin, isoquercitrin, and kaempferitrin., Taxonomic classification of Moringa oleifera is shown in [Table 1].
Whole pods contain isothiocyanate, thiocarbamates, nitrile, O-[2′-hydroxy-3′-(2′′-heptenyloxy)]-propyl undecanoate, methyl-p-hydroxybenzoate, and O-ethyl-4-[(α-l-rhamnosyloxy)-benzyl] carbamate. Fruits contain cytokines, whereas seeds contain high concentrations of benzylglucosinolate, 4-(α-l-rhamnopyranosyloxy)-benzylglucosinolate, 4-(α-l-rhamnosyloxy) benzylisothiocyanate, 4-(α-l-rhamnosyloxy) phenylacetonitrile, and O-ethyl-4-(α-l-rhamnosyloxy) benzyl carbamate.,,,
| Pharmacological Actions|| |
Analgesic, anti-inflammatory, and antipyretic activities
Almost every part of this “miracle tree” has been found to exhibit analgesic activity in different animal models. Extract of leaves, seeds, and bark showed significant analgesic activity in both central (hot plate method) and peripheral models (acetic acid–induced writhing method) in a dose-dependent manner,,, and extracts of leaves exhibited analgesic potency similar to that of indomethacin and antimigraine properties in a dose-dependent manner. Topical application showed efficacy against multiple sclerosis–induced neuropathic pain.
Anti-inflammatory activity of leaf extract has been observed in a carrageenan-induced paw edema model.,, Extracts of bark showed anti-inflammatory activity comparable to diclofenac in the same model. Anti-inflammatory properties of root have also been reported.,Mechanism underlying the anti-inflammatory activity may be attributed to the regulation of neutrophils and c-Jun N-terminal kinase pathway. Active ingredients contributing to anti-inflammatory property are tannins, phenols, alkaloids, flavonoids, carotenoids, β-sitosterol, vanillin, hydroxymellein, moringine, moringinine, β-sitostenone, and 9-octadecenoic acid.,
Leaf extract showed significant antipyretic activity in a Brewer’s yeast–induced pyrexia model. Ethanol and ethyl acetate extracts of seeds also showed significant antipyretic activity.
Aqueous extract of leaves has shown protection against Alzheimer’s disease in a colchicine-induced Alzheimer’s model using behavioral testing (radial Y arm maze task). It protected against Alzheimer’s disease by altering brain monoamine levels and electrical activity. Another study using toluene-ethyl acetate fraction of methanolic extract of leaf showed potent nootropic activity. Leaf extract contains vitamins C and E, which play a significant role in improving memory in patients with Alzheimer’s disease.,
Anticonvulsant activity of leaves was shown in both pentylenetetrazole and maximum electric shock models using male albino mice. Aqueous extract of root suppressed penicillin-induced epileptic seizures in adult albino rats.,
Ethanolic extract of leaves exhibited both central nervous system depressant and muscle relaxant activities in actophotometer and rotarod apparatuses, respectively,,, and also exhibited significant anxiolytic activity in staircase test and elevated plus maze test in a dose-dependent manner.,
Alcoholic and hydromethanolic extracts of leaves and fruits showed a significant growth delay in tumor kinetics in mouse melanoma tumor model studies.,Extract of leaf also exhibited antiproliferative activity on A549 lung cells.,Exploration of effects on prerequisites for cancer metastasis showed that the administration of leaf extract into chick chorioallantoic membrane led to an antiangiogenic effect, which was dose dependent, thereby showing their remarkable anticancer potential.,,, Another study reported that pod extract suppressed azoxymethane and dextran sodium sulfate–induced colon destruction in male, Institute of Cancer Research (ICR) mice.An extract of root and leaf showed a cytotoxic effect against breast cancer, hepatocarcinoma, and colorectal cancer cells in vitro and cisplatin-resistant ovarian cancer cells.,, Flower extract stimulated cell proliferation in normal cells but not in cancer cells, whereas leaf extract showed marked antitumor and hepatoprotective effects, these findings suggest the regenerative potential of MO besides its anticancer effects.
Phytoconstituents such as niazimicin, carbamates, thiocarbamate, nitrile glycosides and others such as quercetin and kaempferol are responsible for the anticancer activity of this plant.,
MO fruits and leaves have antioxidant properties. Extract of leaf showed a concentration-dependent increase in glutathione level and a decrease in malondialdehyde level, fruit extract showed beneficial results in eliminating free radicals, extract of roots significantly reduced iron and FeSO4-induced microsomal lipid peroxidation in a dose-dependent manner.,,,,,, Pods were capable of scavenging peroxyl, superoxyl, and 2, 2-diphenyl-2-picryl hydrazyl (DPPH) radicals.,
Besides displaying antioxidant activity, MO leaf extract also showed a dose-dependent nephroprotective action in an acetaminophen-induced nephrotoxicity model in male BALB/c rats.,, Triterpenoids, moringyne, monopalmitic and di-oleic triglyceride, campesterol, stigmasterol, β-sitosterol, avenasterol, vitamin A, and its precursor beta-carotene have been shown to contribute for antioxidant properties.
Effects on the reproductive system
Leaf extract showed a significant increase in the weight of testis, seminal vesicle, epididymis, and a higher score for epididymal maturity and lumen formation along with an increase in seminiferous tubule diameter (all doses).
Ethanolic extract of leaf protected prepubertal spermatogonial cells in Swiss male albino mice in cyclophosphamide-induced damage model; the possible underlying mechanism may be upregulation of expression of c-Kit and Oct4 transcripts independent of p53-mediated pathway.
The abortive effect of leaf extract on rats after treatment for 10 days after insemination has been reported. Extract showed a synergistic effect with estradiol and an inhibitory effect with progesterone. Fresh leaves of MO contain approximately 11,300–23,000 IU of vitamin A, which has a major role in various anatomical processes, such as reproduction, embryonic growth and development, immunity development, and cell differentiation.,
Extract of leaves has shown hepatoprotective effects against carbon tetrachloride and acetaminophen-induced liver toxicity in Sprague Dawley rats.,,,,, and also hepatoprotective effect against antitubercular drugs and alloxan-induced liver damage in diabetic rats.,This plant-based diet for 21 days showed significant potential in attenuating hepatic injury.,,, Alkaloids, quercetin, kaempferol, flavonoids, ascorbic acid, and benzylglucosinolate were found to be responsible for hepatoprotective activity.,
Gastroprotective and anti-ulcer activities
Extract of leaves remarkably reduced ulcer index in ibuprofen-induced gastric ulcer model and in pyloric ligation test, and a significant reduction in cysteamine-induced duodenal ulcers and stress ulcers was also observed. Bisphenols and flavonoids could be contributing to this property.
Extract of MO leaf significantly reduced cholesterol levels and displayed a protective role on hyperlipidemia induced by iron deficiency in male Wistar rats. Antihypertensive effect of leaf extract on spontaneous hypertensive rats was shown, in addition to reduced chronotropic and inotropic effects in isolated frog hearts.,Active constituents for hypotensive action are niazinin A, niazinin B, and niazimicin. Extract of leaves also showed cardioprotective effects against isoproterenol-induced myocardial infarction in male Wistar albino rats; the mechanism underlying this cardioprotective activity was found to be antioxidant effect, prevention of lipid peroxidation, and protection of histopathological and ultrastructural disturbances caused by isoproterenol.
A study was done of Moringa oleifera Lam. on various tissue systems and it showed reduction in inflammation and lipid accumulation.
Significant reduction in body mass index was observed after oral treatment with leaf powder compared with that in obese control. Treatment of hypercholesterolemia rats with methanolic extract of MO leaf for 49 days showed a remarkable reduction in total cholesterol, triglycerides, and body weight, moreover, liver biomarkers, organ weight, and blood glucose levels were also decreased.,Mechanisms include downregulation of mRNA expression of leptin and resistin and upregulation of adiponectin gene expression in obese rats.
Extract of seeds showed protection against asthma as investigated in various models; the proposed mechanism for this effect was a direct bronchodilator effect combined with anti-inflammatory and antimicrobial actions and inhibition of immediate hypersensitive reaction. Ethanol extract of seeds tested against ovalbumin-induced airway inflammation in guinea pigs showed a significant increase in respiratory parameters and reduction in interleukins in bronchoalveolar lavage.
A randomized, double-blind, placebo-controlled study was carried out on women who were anemic with hemoglobin levels between 8 and 12g/dL and were treated with aqueous extract of moringa leaf, the results showed an increase in mean hemoglobin and mean corpuscular hemoglobin concentration. Another study revealed that when moringa was given to healthy human volunteers for 14 days, a significant improvement in platelet count was observed.,
Extract of leaf showed significant antihyperglycemic and hypoglycemic activity in normal and alloxan-induced diabetic rats.,, An elaborate study was performed to determine the effect of aqueous leaf extract on lipid profile, body weight, glucose, plasma insulin, homeostatic model assessment, and oral glucose tolerance test in insulin-resistant (IR) and type 1 diabetic rat models. IR rats were fed a high-fructose diet, and type 1 diabetic rats were treated with Streptozotocin (STZ) (55mg/kg). IR rats showed an increase in hyperinsulinemia, hyperglycemia, and body weight, whereas STZ-induced diabetic rats showed hyperinsulinemia and hyperglycemia. Leaf extract administration for 60 days returned all the abnormal parameters to normal levels.,,,,
Furthermore, extract of leaf inhibited the formation of advanced glycation end products by reducing monosaccharide-induced protein glycation. Glucomoringin, phenols, flavonoids, quercetin-3-glucoside, fiber, and phenol have been reported to be responsible for antidiabetic activity.
Aqueous and alcoholic extracts of this plant showed anti-urolithiatic activity in a hyperoxaluria-induced rat model,and in ethylene glycol–induced urolithiasis model.
Leaves, flowers, seeds, roots, and bark extracts increased urine output in rats, extract of leaf showed a dose-dependent diuretic action greater than control but less than hydrochlorothiazide. Campesterol, stigmasterol, β-sitosterol, and avenasterol were responsible for this activity.
Ethanolic extract of seeds inhibited passive cutaneous anaphylaxis induced by anti-immunoglobulin G (IgG) antibody and histamine release from mast cells; the mechanism underlying this action could be membrane-stabilizing action and also reduced scratching frequency in an Ovalbumin sensitization model.
This plant showed potent anthelmintic activity, it took less time to paralyze Indian earthworm Pheretima posthuma. In ovicidal assay, ethanolic and aqueous extracts showed 95.89% and 81.72% egg hatch inhibition, respectively, and in larvicidal assay, they showed 56.94% and 92.50% efficacy, respectively.
Extracts of leaf, dried pulp, and seeds showed a significant increase in hydroxyproline content, wound-closure rate, granuloma-breaking strength, and granuloma dry weight, and a decrease in scar area and skin-breaking strength in incision, excision, and dead space wound models in rats.,,,
Studies conducted on the effect of wound healing of leaf extract in diabetic animals showed improved tissue regeneration, decreased wound size, downregulated inflammatory mediators, and upregulated vascular endothelial growth factor in wound tissues, and remarkable antiproliferative and anti-migratory effects on normal human dermal fibroblasts.
Ethanolic extract of leaf showed antimicrobial activity against all the tested bacteria.,,, Chloroform extract reported activity against pathogens such as Salmonella More Details typhi, Pseudomonas aeruginosa, Escherichia More Details coli, and Vibrio cholerae.,
Ethanolic extracts of root and bark possessed antifungal activity against Aspergillus niger, Neurospora crassa, Rhizopus stolonifer, and Microsporum gypseum,,, and also showed inhibitory activity against Leishmania donovani. Many studies suggest that extracts of seeds could be a potential option to purify water sources as it inhibited bacterial growth in agar and nutrient medium.
Methanolic extract of leaves inhibited urinary tract pathogens, such as Staphylococcus aureus, Klebsiella pneumoniae, S. saprophyticus, and E. coli.,,,,
Flavonoids, tannins, steroids, alkaloids, saponins, benzyl isothiocyanate, and benzylglucosinolate were found to be responsible for antimicrobial activity,, whereas pterygospermin was found to be responsible for antifungal activity.,
Methanolic extract of this plant stimulated both humoral and cellular immune response.,In addition, extract showed an increase in optical density and stimulation index, indicating splenocyte proliferation.
Extract of seeds showed significant reduction in gastrointestinal motility and were found to be effective in castor oil induced diarrhoea in male Wister rats.,,Antidiarrheal activity can be attributed to phytochemical ingredients such as tannins, saponins, and flavonoids.
Leaf extract exhibited a reduction in unwanted sebum secretions from sebaceous gland during winter in humans. A systematic review and meta-analysis have clearly accounted this plant as a galactagogue. Methanolic extract of root showed local anesthetic action in frog and guinea pig models. Significant CYP3A4 inhibitory effects was exhibited by MO leaf extract. Thus, MO has a great potential for herb–drug interactions.
| Conclusion|| |
The key objective of this review was to unfold and explore the pharmacological and medicinal values of MO; preclinical studies revealed that this plant possesses analgesic, anti-inflammatory, antipyretic, anticancer, antioxidant, nootropic, hepatoprotective, gastroprotective, anti-ulcer, cardiovascular, anti-obesity, antiepileptic, antiasthmatic, antidiabetic, anti-urolithiatic, diuretic, local anesthetic, anti-allergic, anthelmintic, wound healing, antimicrobial, immunomodulatory, and antidiarrheal effects. These activities may be attributed to phytoconstituents present in its root, stem, bark, leaf, flower, pod, and seeds. MO offers immense value, which can form the basis of drug supplementation, and should be used for the promotion of public health. It may also be considered for the treatment of different diseases as an alternative therapy.
We sincerely acknowledge the contribution of Dr. Tamilisetti Vidya Sagar, Assistant Professor, Department of Pharmacology, GSL Medical College, Rajahmundry, Andhra Pradesh, India, in drafting the manuscript and coordinating with all coauthors after corrections and making necessary changes.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Durgesh KD, Jyotsna D, Anil K, Ratan KG. A multipurpose tree—Moringa oleifera
. Int J Pharm Chem Sci 2013;10:415-23.
Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera
: A food plant with multiple medicinal uses.Phytother Res 2007;10:17-25.
Bhattacharya A, Naik MR, Agrawal D, Rath K, Kumar S, Mishra SS. Anti-pyretic, anti-inflammatory, and analgesic effects of leaf extract of drumstick tree. J Young Pharm 2014;10:1-5.
Dilard CJ, German JB. Phytochemicals: nutraceuticals and human health: a Review. J Sci Food Agric 2000;10:1744-56.
Awanish P, Rishabh DP, Poonam TP, Gupta JH, Saumya BA. Moringa oleifera
Lam. (Sahijan)—a plant with a plethora of diverse. Therapeutic benefits: an updated retrospection. Med Arom Plants 2012;10:1-8.
Amrutia JN, Lala M, Srinivasa U, Shabaraya AR, Semuel MR. Anticonvulsant activity of Moringa oleifera
leaf. Int Res J Pharm 2011;10:160-2.
Mehta J, Shukla A, Bukhariya V, Charde R. The magic remedy of Moringa oleifera
: an overview. Int J Biomed Adv Res 2011;10:215-27.
Ndiaye M, Dieye AM, Mariko F, Tall A, Sall Diallo A, Faye B. [Contribution to the study of the anti-inflammatory activity of Moringa oleifera
(Moringaceae)]. Dakar Med 2002;10:210-2.
Saini RK, Shetty NP, Giridhar P. Carotenoid content in vegetative and reproductive parts of commercially grown Moringa oleifera
Lam. cultivars from India by LC–APCI–MS. Eur Food Res Technol 2014;10:971-8.
Saini RK, Shetty NP, Prakash M, Giridhar P. Effect of dehydration methods on retention of carotenoids, tocopherols, ascorbic acid and antioxidant activity in Moringa oleifera
leaves and preparation of a RTE product. J Food Sci Technol 2014;10:2176-82.
Amaglo NK, Bennett RN, Lo Curto RB, Rosa EAS, Lo Turco V, Giuffrida A, et al
. Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera
L. grown in Ghana. Food Chem 2010;10:1047-54.
Coppin JP, Xu Y, Chen H, Pan MH, Ho CT, Juliani R, et al
. Determination of flavonoids by LC/MS and anti-inflammatory activity in Moringa oleifera
. J Funct Foods 2013;10:1892-9.
Saini RK, Manoj P, Shetty NP, Srinivasan K, Giridhar P. Relative bioavailability of folate from the traditional food plant Moringa oleifera
l. as evaluated in a rat model. j Food Sci Technol 2016;10:511-20.
Saini RK, Shetty NP, Giridhar P. GC-FID/MS analysis of fatty acids in Indian cultivars of Moringa oleifera
: potential sources of PUFA. J Am Oil Chem Soc 2014;10:1029-34.
Saini RK, Manoj P, Shetty NP, Srinivasan K, Giridhar P. Dietary iron supplements and Moringa oleifera
leaves influence the liver hepcidin messenger rna expression and biochemical indices of iron status in rats. Nutr Res 2014;10:630-8.
Bhattacharya A, Ghosh G, Agrawal D, Sahu PK, Kumar S, Mishra SS. GC-MS profiling of ethanolic extract of Moringa oleifera
leaf. Int J Pharm Bio Sci 2014;10:263-75.
Bennett RN, Mellon FA, Foidl N, Pratt JH, Dupont MS, Perkins L, et al
. Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera
L. (horseradish tree) and Moringa stenopetala
L. J Agric Food Chem 2003;10:3546-53.
Nwosu MO, Okafor JI. Preliminary studies of the antifungal activities of some medicinal plants against Basidiobolus
and some other pathogenic fungi. Mycoses 1995;10:191-5.
Kerharo PJ. Un remede popularized Sengalais: le ‘Nebreday’ (Moringa oleifera
lann. employs therapeutiques en milieu Africain chimie et pharmacologie. Plantes Med Phytother 1969;10:14-219.
Faizi S, Siddiqui BS, Saleem R, Siddiqui S, Aftab K, Gilani AH. Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera
and their effect on blood pressure. J Nat Prod 1994;10:1256-61.
Bhattacharya SB, Das AK, Banerjee N. Chemical investigation on the gum exudates from Sajna (Moringa oleifera
). Carbohydrate Res 1982;10:253-62.
Khare GC, Singh V, Gupta PC. A new leucoanthocyanin from Moringa oleifera
gum. J Indian Chem Soc 1997;10:247-8.
Mensah JK, Ikhajiagbe B, Edema NE, Emokhor J. Phytochemical nutritional and antibacterial properties of dried leaf powder of Moringa oleifera
(Lam) from Edo Central Province, Nigeria. J Nat Prod Plant Resource 2012;10:107-12.
Siddhuraju P, Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera
Lam.) leaves. J Agric Food Chem 2003;10:2144-55.
Pramanik A, Islam SS. Chemical investigation of aqueous extract of the mature and premature flowers of Moringa oleifera
(Sajina) and structural studies of a polysaccharide isolated from its premature flowers. Indian J Chem 1998;10:676-82.
Nadkarni KM. Indian materia medica Vol. 1. 3rd ed. Bombay, India: Popular Prakashan; 2000. p. 811.
Faizi S, Siddiqui BS, Saleem R, Aftab K, Shaheen F, Gilani AH. Hypotensive constituents from the pods of Moringa oleifera
. Planta Med 1998;10:225-8.
Nagar PK, Iyer RI, Sircar PK. Cytokinins in developing fruits of Moringa pterigosperma
Gaertn. Physiol Plant 1982;10:45-50.
Dahot MU, Memon AR. Nutritive significance of oil extracted from Moringa oleifera
seeds. J Phar Univ Karachi 1985;10:75-80.
Anwar F, Bhanger MI. Analytical characterization of Moringa oleifera
seed oil grown in temperate regions of Pakistan. J Agric Food Chem 2003;10:6558-63.
Dayrit IM, Alcantar AD, Villasenor IM. Studies on Moringa oleifera
seeds, Part I. The antibiotic compound and its deactivation in aqueous solution. Philip J Sci 1990;10:23-32.
Guevara AP, Vargas C, Sakurai H, Fujiwara Y, Hashimoto K, Maoka T, et al
. An antitumor promoter from Moringa oleifera
Lam. Mutat Res 1999;10:181-8.
Bhattacharya A, Agrawal D, Sahu PK, Kumar S, Mishra SS, Patnaik S. Analgesic effect of ethanolic leaf extract of Moringa oleifera
on albino mice. Indian J Pain 2014;10:89-94.
Kumbhare M, Sivakumar T. Anti-inflammatory and analgesic activity of stem bark of Moringa oleifera
. Pharmacol Online 2011;10:641-50.
Nitin GS, Bonde CG, Patil VV, Narkhede SB, Patil AP, Kakade RT. Analgesic activity of seeds of Moringa oleifera
Lam. Int J Green Pharm 2008;10:108-10.
Manaheji H, Jafari S, Jalal Z, Shamsali R, Reza T. Analgesic effects of methanolic extracts of the leaf or root of Moringa oleifera
on complete Freund’s adjuvant-induced arthritis in rats. J Chin Integ Med 2011;10:217-22.
Kanchan PU, Vinod DR, Vijay BM. Antimigraine activity study of Moringa oleifera
leaf juice. Int J Green Pharm 2012;10:204-7.
Jurairat K, Jintanaporn W, Supaporn M, Wipawee T, Cholathip T, Panakaporn W, et al
. Moringa oleifera
leaves extract attenuates neuropathic pain induced by chronic constriction injury. Am J Appl Sci 2012;10:1182-7.
Gurvinder PS, Rakesh G, Sudeep B, Sandeep KS. Anti-inflammatory evaluation of leaf extract of Moringa oleifera
. J Pharmaceut Sci Innovation 2012;10:22-4.
Sharma R, Vaghela JS. Anti-inflammatory activity of Moringa oleifera
leaf and pod extracts against carrageenan induced paw edema in albino mice. Pharmacol Online 2011;10:140-4.
Bhattacharya A, Agrawal D, Sahu PK, Swain TR, Kumar S, Mishra SS. Anti-inflammatory effect of ethanolic extract of Moringa oleifera
leaves on albino rats. RJPBCS 2014;10:540-4.
Ezeamuzie IC, Ambakederemo AW, Shode FO, Ekwebelem SC. Anti-inflammatory effects of Moringa oleifera
root extract. Int J Pharmacogn 1996;10:207-12.
McKnight M, Allen J, Waterman JD, Hurley S, Idassi J, Minor RC. Moringa tea blocks acute lung inflammation induced by swine confinement dust through a mechanism involving TNF-α expression, c-Jun N-terminal kinase activation and neutrophil regulation. Am J Immunol 2014;10:73-87.
Venkateshwara KN, Gopalakrishnan V, Loganathan V. Antiinflammatory action of Moringa oleifera Lam. Anc Sci Life 1999;10:195-8.
Bhattacharya A, Behera R, Agrawal D, Sahu PK, Kumar S, Mishra SS. Antipyretic effect of ethanolic extract of Moringa oleifera
leaves on albino rats. Tanta Med J 2014;10:74-8.
Kumar S. Medicinal importance of Moringa oleifera
: drumstick plant. Indian J Sci Res 2017;10:129-32.
Ranira G, Rimi H, Kaushik R, Debajani G. Effect of Moringa oleifera
in experimental model of Alzheimer’s disease: role of antioxidants. Ann Neurosci 2005;10:33-6.
Ganguly R, Guha D. Alteration of brain monoamines and EEG wave pattern in rat model of Alzheimer’s disease and protection by Moringa oleifera
. Indian J Med Res 2008;10:744-51.
Mohan M, Kaul N, Punekar A, Girnar R, Junnare P, Patil L. Nootropic activity of Moringa oleifera
leaves. J Nat Remedies 2005;10:59-62.
Akram M, Nawaz A. Effects of medicinal plants on Alzheimer’s disease and memory deficits. Neural Regen Res 2017;10:660-70.
More SV, Kumar H, Cho DY, Yun YS, Choi DK. Toxin-induced experimental models of learning and memory impairment. Int J Mol Sci 2016;10:1447.
Ray K, Guha D. Effect of Moringa oleifera
root extract on penicillin-induced epileptic rats. Biogenic Amines 2005;10:223-31.
Fathima SN, Vasudevamurthy S, Rajkumar N. A review on phytoextracts with antiepileptic property. J Pharm Sci Res 2015;10:994-1003.
Bhattacharya A, Naik MR, Agrawal D, Sahu PK, Kumar S, Mishra SS. CNS depressant and muscle relaxant effect of ethanolic leaf extract of Moringa oleifera
on albino rats. Int J PharmTech Res 2014;10:1141-9.
Ray K, Hazra R, Debnath PK, Guha D. Role of 5-hydroxytryptamine in Moringa oleifera
induced potentiation of pentobarbitone hypnosis in albino rats. Indian J Exp Biol 2004;10:632-5.
Kaur G, Invally M, Sanzagiri R, Buttar HS. Evaluation of the antidepressant activity of Moringa oleifera
alone and in combination with fluoxetine. J Ayurveda Integr Med 2015;10:273-9.
Bhattacharya A, Santra S, Mahapatra S, Sahu PK, Agrawal D, Kumar S. Study of anxiolytic effect of ethanolic extract of drumstick tree leaves on albino mice in a basic neuropharmacology laboratory of a postgraduate teaching institute. J Health Res Rev 2016;10:41-7.
Lakshmi BV, Sudhakar M, Ramya RL. Anti-anxiety activity of Moringa oleifera
assessed using different experimental anxiety models in mice. J Pharm Res 2014;10:343-8.
Purwal L, Shrivastava V, Jain UK. Anti-tumour activity of crude extracts of leaves of Moringa oleifera
(Moringaceae). Indian Drugs 2010;10:31-4.
Jung IL, Lee JH, Kang SC. A potential oral anticancer drug candidate, Moringa oleifera
leaf extract, induces the apoptosis of human hepatocellular carcinoma cells. Oncol Lett 2015;10:1597-604.
Tiloke C, Phulukdaree A, Chuturgoon AA. The antiproliferative effect of Moringa oleifera
crude aqueous leaf extract on cancerous human alveolar epithelial cells. BMC Complement Altern Med 2013;10:226.
Sreelatha S, Jeyachitra A, Padma PR. Antiproliferation and induction of apoptosis by Moringa oleifera
leaf extract on human cancer cells. Food Chem Toxicol 2011;10:1270-5.
Pachava VR, Krishnamurthy PT, Dahabal SP, Wadhwani A, Chinthamani PK. Anti-angiogenic potential of ethyl acetate extract of Moringa oleifera
Lam leaves in chick chorioallantoic membrane (CAM) assay. J Nat Prod Plant Resource 2017;10:18-22.
Al-Asmari AK, Albalawi SM, Athar MT, Khan AQ, Al-Shahrani H, Islam M. Moringa oleifera
as an anti-cancer agent against breast and colorectal cancer cell lines. PLoS One 2015;10:e0135814.
Mojzis J, Varinska L, Mojzisova G, Kostova I, Mirossay L. Antiangiogenic effects of flavonoids and chalcones. Pharmacol Res 2008;10:259-65.
Tragulpakseerojn J, Yamaguchi N, Pamonsinlapatham P, Wetwitayaklung P, Yoneyama T, Ishikawa N, et al
. Anti-proliferative effect of Moringa oleifera
Lam (Moringaceae) leaf extract on human colon cancer HCT116 cell line. Tropi J Pharm Res 2017;10:371-8.
Budda S, Butryee C, Tuntipopipat S, Rungsipipat A, Wangnaithum S, Lee JS, et al
. Suppressive effects of Moringa oleifera
Lam pod against mouse colon carcinogenesis induced by azoxymethane and dextran sodium sulfate. Asian Pac J Cancer Prev 2011;10:3221-8.
Abd-Rabou AA, Abdalla AM, Ali NA, Zoheir KM. Moringa oleifera
root induces cancer apoptosis more effectively than leave nanocomposites and its free counterpart. Asian Pac J Cancer Prev 2017;10:2141-9.
Bose CK. Possible role of Moringa oleifera
Lam. root in epithelial ovarian cancer. Medgenmed 2007;10:26.
Del Mar Zayas-Viera M, Vivas-Mejia PE, Reyes J. Anticancer effect of Moringa oleifera
leaf extract in human cancer cell lines. J Health Disparities Res Prac 2016;10:102.
Fernandes EE, Pulwale AV, Patil GA, Moghe AS. Probing regenerative potential of Moringa oleifera
aqueous extracts using in vitro
cellular assays. Pharmacognosy Res 2016;10:231-7.
Purwal L, Pathak AK, Jain UK. In vivo
anticancer activity of the leaves and fruits of Moringa oleifera
on mouse melanoma. Pharmacol Online 2010;10:655-65.
Charoensin S. Antioxidant and anticancer activities of Moringa oleifera
leaves. J Med Plants Res 2014;10:318-25.
Luqman S, Suchita S, Ritesh K, Anil KM, Debabrata C. Experimental assessment of Moringa oleifera
leaf and fruit for its antistress, antioxidant, and scavenging potential using in vivo
and in vitro
. Evid Based Complement Alternat Med 2012;10:1-17.
Sreelatha S, Padma PR. Antioxidant activity and total phenolic content of Moringa oleifera
leaves in two stages of maturity. Plant Foods Hum Nutr 2009;10:303-11.
Pasha S, Khaleel M, Som S. Effect of Moringa oleifera
on stress induced brain lipid peroxidation in rats. Res J Pharm Biol Chem Sci 2010;10:336-42.
Kumar V, Pandey N, Mohan N, Singh RP. Antibacterial and antioxidant activity of different extract of Moringa oleifera
leaves—an in vitro
study. Int J Pharm Sci Rev Res 2012;10:89-94.
Singh BN, Singh BR, Singh RL, Prakash D, Dhakarey R, Upadhyay G, et al
. Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera
. Food Chem Toxicol 2009;10:1109-16.
Satish A, Reddy PV, Sairam S, Ahmed F, Urooj A. Antioxidative effect and DNA protecting property of Moringa oleifera
root extracts. J. Herbs Spices Med Plants 2014;10: 209-20.
Wangcharoen W, Gomolmanee S. Antioxidant capacity and total phenolic content of Moringa oleifera
grown in Chiang Mai, Thailand. Thai J Agric Sci 2011;10:118-24.
Sinha M, Das DK, Bhattacharjee S, Majumdar S, Dey S. Leaf extract of Moringa oleifera
prevents ionizing radiation-induced oxidative stress in mice. J Med Food 2011;10:1167-72.
Paliwal R, Sharma V, Pracheta SS. Elucidation of free radical scavenging and antioxidant activity of aqueous and hydro-ethanolic extracts of Moringa oleifera
pods. Res J Pharm Technol 2011;10:566-71.
Atawodi SE, Atawodi JC, Idakwo GA, Pfundstein B, Haubner R, Wurtele G, et al
. Evaluation of the polyphenol content and antioxidant properties of methanol extracts of the leaves, stem, and root barks of Moringa oleifera
Lam. J Med Food 2010;10:710-6.
Karthivashan G, Kura AU, Arulselvan P, Md Isa N, Fakurazi S. The modulatory effect of Moringa oleifera
leaf extract on endogenous antioxidant systems and inflammatory markers in an acetaminophen-induced nephrotoxic mice model. PeerJ 2016;10:e2127.
He TB, Huang YP, Huang Y, Wang XJ, Hu JM, Sheng J. Structural elucidation and antioxidant activity of an arabinogalactan from the leaves of Moringa oleifera
. Int J Biol Macromol 2018;10:126-33.
Aa AB, Om J, Ts E, Ga A. Preliminary phytochemical screening, antioxidant and antihyperglycaemic activity of Moringa oleifera
leaf extracts. Pak J Pharm Sci 2017;10:2217-22.
Stavros L, John T. Extraction and identification of natural antioxidants from the seeds of the Moringa oleifera
tree variety of Malawi. J Am Oil Chem Soc 2002;10:677-83.
Cajuday LA, Pocsidio GL. Effects of Moringa oleifera
Lam. (Moringaceae) on the reproduction of male mice (Musmusculus
). J Med Plants Res 2010;10:1115-21.
Nayak G, Honguntikar SD, Kalthur SG, D’Souza AS, Mutalik S, Setty MM, et al
. Ethanolic extract of Moringa oleifera
Lam. leaves protect the pre-pubertal spermatogonial cells from cyclophosphamide-induced damage. j Ethnopharmacol 2016;10:101-9.
Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol 1992;10:147-54.
Shukla S, Mathur R, Prakash AO. Histoarchitecture of the genital tract of ovariectomized rats treated with an aqueous extract of Moringa oleifera
roots. J Ethnopharmacol 1989;10:249-61.
Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J, Bertoli S. Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera
leaves: an overview. Int J Mol Sci 2015;10:12791-835.
Vergara-Jimenez M, Almatrafi MM, Fernandez ML. Bioactive components in Moringa oleifera
leaves protect against chronic disease. Antioxidants 2017;10:91.
Patel RK, Patel MM, Kanzariya NR, Vaghela KR, Patel RK, Patel NJ. In vitro
hepatoprotective activity of Moringa oleifera
Lam. leaves on isolated rat hepatocytes. Int J Pharm Sci 2010;10:457-63.
Nanjappaiah HM, Shivakumar H. Prophylactic and curative effects of Moringa oleifera
Lam. pods in CCl4 damaged rat liver. Indian J Nat Prod Resours 2012;10:541-6.
Hamza AA. Ameliorative effects of Moringa oleifera
Lam. seed extract on liver fibrosis in rats. Food Chem Toxicol 2010;10:345-55.
Fakurazi S, Hairuszah I, Nanthini U. Moringa oleifera
Lam. prevents acetaminophen induced liver injury through restoration of glutathione level. Food Chem Toxicol 2008;10:2611-5.
Das N, Kunal S, Santinath G, Bernard F, Sanjit D. Moringa oleifera
Lam. ethanolic leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet. Indian J Exp Biol 2012;10:404-12.
Umaya SR, Parvatham R. Efficacy of Moringa oleifera
and aloe vera on aflatoxin b1-induced hepatotoxicity in rats. Res J Biotechnol 2009;10:20-4.
Pari L, Kumar NA. Hepatoprotective activity of Moringa oleifera
on antitubercular drug-induced liver damage in rats. J Med Food 2002;10:171-7.
Omodanisi EI, Aboua YG, Chegou NN, Oguntibeju OO. Hepatoprotective, antihyperlipidemic, and anti-inflammatory activity of Moringa oleifera
in diabetic-induced damage in male Wistar rats. Pharmacognosy Res 2017;10:182-7.
Eldaim MA, Elrasoul SA, Elaziz SA. An aqueous extract from Moringa oleifera
leaves ameliorates hepatotoxicity in alloxan-induced diabetic rats. Biochem Cell Biol 2017;10:524-30.
Adeyemi OS, Aroge CS, Akanji MA. Moringa oleifera
-based diet protects against nickel-induced hepatotoxicity in rats. J Biomed Res 2017;10:350.
Toppo R, Roy BK, Gora RH, Baxla SL, Kumar P. Hepatoprotective activity of Moringa oleifera
against cadmium toxicity in rats. Vet World 2015;10:537-40.
Gilani AH, Janbaz KH, Shah BH. Quercetin exhibits hepatoprotective activity in rats. Biochem Soc Trans 1997;10:S619.
Ruckmani K, Kavimani S, Anandan R, Jaykar B. Effect of Moringa oleifera
Lam. on paracetamol induced hepatotoxicity. Indian J Pharm Sci 1998;10:33-5.
Dhimmar N, Patel NM, Gajera V, Lambole V. Pharmacological activities of Moringa oleifera
: an overview. Res J Pharm Tech 2015;10:476-80.
Devaraj VC, Asad M, Prasad S. Effect of leaves and fruits of Moringa oleifera
on gastric and duodenal ulcers. Pharm Biol 2007;10:332-8.
Debnath S, Guha D. Role of Moringa oleifera
on enterochromaffin cell count and serotonin content of experimental ulcer model. Indian J Exp Biol 2007;10:726-31.
Ndong M, Uehara M, Katsumata S, Sato S, Suzuki K. Preventive effects of Moringa oleifera
(Lam.) on hyperlipidemia and hepatocyte ultrastructural changes in iron deficient rats. Biosci Biotechnol Biochem 2007;10:1826-33.
Dangi SY, Jolly CI, Narayanan S. Antihypertensive activity of the total alkaloids from the leaves of Moringa oleifera
. Pharm Biol 2002;10:144-8.
Randriamboavonjy JI, Loirand G, Vaillant N, Lauzier B, Derbré S, Michalet S, et al
. Cardiac protective effects of Moringa oleifera
seeds in spontaneous hypertensive rats. Am J Hypertens 2016;10:873-81.
Gilani AH, Aftab K, Suria A, Siddiqui S, Salem R, Siddique BS, et al
. Pharmacological studies on hypotensive and spamolytic activities of pure compounds from Moringa oleifera
. Phytother Res 1994;10:87-91.
Nandave M, Ojha SK, Joshi S, Kumari S, Arya DS. Moringa oleifera
leaf extract prevents isoproterenol-induced myocardial damage in rats: evidence for an antioxidant, antiperoxidative, and cardioprotective intervention. J Med Food 2009;10:47-55.
Barbagallo I, Distefano VA, Nicolosi D, Maravigna A, Lazzarino G, Rosa MD, et al
. Moringa oleifera
Lam. improves lipid metabolism during adipogenic differentiation of human stem cells. Eur Rev Med Pharmacol Sci 2016;10:5223-32.
Nahar S, Faisal FM, Iqbal J, Rahman MM, Yusuf MA. Antiobesity activity of Moringa oleifera
leaves against high fat diet-induced obesity in rats. Int J Basic Clin Pharmacol 2016;10:1263-8.
Bais S, Singh GS, Sharma R. Anti-obesity and hypolipidemic activity of Moringa oleifera
leaves against high fat diet-induced obesity in rats. Adv Biol 2014;10:1-9.
Pare D, Hilou A, Ouedraogo N, Guenne S. Ethnobotanical study of medicinal plants used as anti-obesity remedies in the nomad and hunter communities of Burkina Faso. Medicines 2016;10:9.
Metwally FM, Rashad MH, Ahmed HH, Mahnoud AA, Raouf ER, Abdalla AM. Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera
in the experimental model. Asian Pac J Trop Biomed 2017;10:214-21.
Anita M, Babita A. Investigation into the mechanism of action of Moringa oleifera
for its anti-asthmatic activity. Orient Pharm Exp Med 2008;10:24-31.
Goyal BR, Goyal RK, Mehta AA. Investigation into the mechanism of anti-asthmatic action of Moringa oleifera
. J Diet Suppl 2009;10:313-27.
Mahajan SG, Mehta AA. Effect of Moringa oleifera
Lam. seed extract on ovalbumin-induced airway inflammation in guinea pigs. Inhal Toxicol 2008;10:897-909.
Suzana D, Suyatna FD, Azizahwati, Andrajati R, Sari SP, Mun’im A. Effect of Moringa oleifera
leaves extract against hematology and blood biochemical value of patients with iron deficiency anaemia. J Young Pharm 2017;10:s79-84.
Adegbite OA, Omolaso B, Seriki SA, Shatima C. Effects of Moringa oleifera
leaves on hematological indices in humans. Ann Hematol Oncol 2016;10:1107.
Archibong AN, Nku CO, Ofem OE. Extract of Moringa oleifera
attenuates hematological parameters following salt loading. MicroMedicine 2017;10:24-30.
Manohar VS, Jayasree K, Kiran K, Rupa ML, Rohit D, Chandrasekhar N. Evaluation of hypoglycaemic and antihyperglycemic effect of freshly prepared aqueous extract of Moringa oleifera
leaves in normal and diabetic rabbits. J Chem Pharm Res 2012;10:249-53.
Jaiswal D, Kumar Rai P, Kumar A, Mehta S, Watal G. Effect of Moringa oleifera
Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmacol 2009;10:392-6.
Yassa HD, Tohamy AF. Extract of Moringa oleifera
leaves ameliorates streptozotocin-induced diabetes mellitus in adult rats. Acta Histochem 2014;10:844-54.
Sugunabai J, Jayaraj M, Karpagam T, Varalakshmi B. Antidiabetic efficiency of Moringa oleifera
and Solanum nigrum
. Int J Pharm Pharm Sci 2014;10:40-2.
Sai MD, Ramesh B, Sarala KD. Evaluation of antidiabetic and antihyperlipidemic potential of aqueous extract of Moringa oleifera
in fructose fed insulin resistant and STZ induced diabetic Wistar rats: a comparative study. Asian J Pharm Clin Res 2012;10:67-72.
Khan W, Parveen R, Chester K, Parveen S, Ahmad S. Hypoglycemic potential of aqueous extract of Moringa oleifera
leaf and in vivo
gc-ms metabolomics. Front Pharmacol 2017;10:577.
Jangir RN, Jain GC. Antidiabetic and antioxidant potential of hydroalcoholic extract of Moringa oleifera
leaves in streptozotocin-induced diabetic rats. Eur J Pharm Sci 2016;10:438-50.
Odedele LO, Ajao FO, Yusuf J, Adu FD. Effect of aqueous Moringa
seed extract on oxidative stress in alloxan-induced gestational diabetic rats. Med Res Arch 2017;10:1-14.
Nunthanawanich P, Sompong W, Sirikwanpong S, Mäkynen K, Adisakwattana S, Dahlan W, et al
. Moringa oleifera
aqueous leaf extract inhibits reducing monosaccharide-induced protein glycation and oxidation of bovine serum albumin. Springerplus 2016;10:1098.
Al-Malki AL, El Rabey HA. The antidiabetic effect of low doses of Moringa oleifera
Lam. seeds on streptozotocin induced diabetes and diabetic nephropathy in male rats. Biomed Res Int 2015;10:381040.
Karadi RV, Gadge NB, Alagawadi KR, Savadi RV. Effect of Moringa oleifera
Lam. root-wood on ethylene glycol induced urolithiasis in rats. J Ethnopharmacol 2006;10:306-11.
Karadi RV, Palkar MB, Gaviraj EN, Gadge NB, Mannur VS, Alagawadi KR. Antiurolithiatic property of Moringa oleifera
root bark. Pharm Biol 2008;10:861-5.
Paikra BK, Dhongade HKJ, Gidwani B. Phytochemistry and pharmacology of Moringa oleifera
Lam. J Pharmacopuncture 2017;10:194-200.
Caceres A, Saravia A, Rizzo S, Zabala L, Leon ED, Nave F. Pharmacologic properties of Moringa oleifera
1: preliminary screening for antimicrobial activity. J Ethnopharmacol 1992;10:233-7.
Mahajan SG, Mehta AA. Inhibitory action of ethanolic extract of seeds of Moringa oleifera
Lam. on systemic and local anaphylaxis. j Immunotoxicol 2007;10:287-94.
Hagiwara A, Hidaka M, Takeda S, Yoshida H, Kai H, Sugita C, et al
. Anti-allergic action of aqueous extract of Moringa oleifera
Lam. leaves in mice. Eur J Med Plants 2016;10:1-10.
Rastogi T, Bhutda V, Moon K, Aswar PB, Khadabadi SS. Comparative study on the anthelmintic activity of Moringa oleifera
and Vitex negundo
. Asian J Res Chem 2009;10:181-2.
Cabardo DE Jr, Portugaliza HP. Anthelmintic activity of Moringa oleifera
seed aqueous and ethanolic extracts against Haemonchus contortus
eggs and third stage larvae. Int J Vet Sci Med 2017;10:30-4.
Rathi B, Patil PA, Baheti AM. Evaluation of aqueous extract of pulp and seeds of Moringa oleifera
for wound healing in albino rats. J Nat Remedies 2004;10:145-9.
Rathi BS, Bodhankar SL, Baheti AM. Evaluation of aqueous leaves extract of Moringa oleifera
Linn. for wound healing in albino rats. Indian J Exp Biol 2006;10:898-901.
Momoh MA, Salome CA, Onyishi IV. Natural healing compound for the treatment of excision and incision wound in rat’s model. Int J Pharm Sci Rev Res 2013;10:1-5.
Lambole V, Kumar U. Effect of Moringa oleifera
Lam. on normal and dexamethasone suppressed wound healing. Asian Pac J Trop Biomed 2012;10:S219-23.
Muhammad AA, Arulselvan P, Cheah PS, Abas F, Fakurazi S. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera
Lam. on experimentally induced diabetic animal model. Drug Des Devel Ther 2016;10:1715-30.
Gothai S, Arulselvan P, Tan WS, Fakurazi S. Wound healing properties of ethyl acetate fraction of Moringa oleifera
in normal human dermal fibroblasts. J Intercult Ethnopharmacol 2016;10:1-6.
Rahman MM, Sheikh MM, Sharmin SA, Islam MS, Rahman MA, Rahman MM, et al
. Antibacterial activity of leaf juice and extracts of Moringa oleifera
Lam. against some human pathogenic bacteria. Chiang Mai University J Nat Sci 2009;10:219-28.
Jabeen R, Shahid M, Jamil A, Ashraf M. Microscopic evaluation of the antimicrobial activity of seed extracts of Moringa oleifera
. Pakistan J Bot 2008;10:1349-58.
Patel P, Patel N, Patel D, Desai S, Meshram D. Phytochemical analysis and antifungal activity of Moringa oleifera
. Int J Pharm Pharm Sci 2014;10:144-7.
Devendra BN, Srinivas N, Prasad TV, Swarna LP. Antimicrobial activity of Moringa oleifera
Lam. leaf extract against selected bacterial and fungal strains. Int J Pharm Bio Sci 2011;10:13-8.
Abalaka ME, Daniyan SY, Oyeleke SB, Adeyemo SO. The antibacterial evaluation of Moringa oleifera
leaf extracts on selected bacterial pathogens. J Microbiol Res 2012;10:1-4.
Elangovan M, Rajalakshmi A, Jayachitra A, Mathi P, Bhogireddy N. Analysis of phytochemicals, antibacterial and antioxidant activities of Moringa oleifera
Lam. leaf extract—an in vitro
study. Int J Drug Dev Res 2014;10:173-80.
Jha N, Mohanka R, Azad R. Antifungal investigation of the constituents of Moringa oleifera
Lam. root bark extract. Asian J Chem 2009;10:7437-9.
Zaffer M, Ganie SA, Gulia SS, Yadav SS, Singh R, Ganguly S. Antifungal efficacy of Moringa oleifera
Lam. AJPCT 2015;10:28-33.
Ferreira PM, Carvalho AF, Farias DF, Cariolano NG, Melo VM, Queiroz MG, et al
. Larvicidal activity of the water extract of Moringa oleifera
seeds against Aedes aegypti
and its toxicity upon laboratory animals. An Acad Bras Cienc 2009;10:207-16.
Kaur A, Kaur PK, Singh S, Singh IP. Antileishmanial compounds from Moringa oleifera
Lam. Z Naturforsch C 2014;10:110-6.
Dasgupta S, Gunda NSK, Mitra SK. Evaluation of antimicrobial activity of Moringa oleifera
seed extract as a sustainable solution for portable water. RSC Advances 2016;10:25918-26.
Abdalla AM, Alwasilah HY, Mahjoub RA, Hind Ibrahim Mohammed HI, Yagoub M. Evaluation of antimicrobial activity of Moringa oleifera
leaf extracts against pathogenic bacteria isolated from urinary tract infected patients. J Adv Lab Res Biol 2016;10:47-51.
Rockwood JL, Anderson BG, Casamatta DA. Potential uses of Moringa oleifera
and an examination of antibiotic efficacy conferred by Moringa oleifera
seed and extract using crude extraction techniques available to undeserved indigenous populations. Int J Phytother Res 2013;10:61-71.
Oluduro AO. Evaluation of antimicrobial properties and nutritional potentials of Moringa oleifera
Lam. leaf in south-western Nigeria. Malays J Microbiol 2012;10:59-67.
Alozie YE, Sonye CU. Antimicrobial activity of Moringa oleifera
leaf against isolates of beef offal. Br Microbiol Res J 2015;10:1-7.
Singh K, Tafida GM. Antibacterial activity of Moringa oleifera
(Lam) leaves extracts against some selected bacteria. Int J Pharm Pharm Sci 2014;10:52-4.
Vinoth R, Manivasagaperumal R, Balamurugan S. Phytochemical analysis and antibacterial activity of Moringa oleifera
Lam. Int J Res Biol Sci 2012;10:98-102.
Pinal P, Nivedita P, Dhara P, Sharav D, Dhananjay M. Phytochemical analysis and antifungal activity of Moringa oleifera
. Int J Pharm Pharm Sci 2014;10:144-7.
Rao RR, George M, Pandalai KM. Pterygospermin; the antibacterial principle of Moringa pterygosperma
, Gaertn. Nature 1946;10:745.
Fahey JW. Moringa oleifera
: a review of the medical evidence for its nutritional, therapeutic and prophylactic properties. Trees Life J 2005;10:5.
Sudha P, Asdaq SM, Dhamingi SS, Chandrakala GK. Immunomodulatory activity of methanolic leaf extract of Moringa oleifera
in animals. Indian J Physiol Pharmacol 2010;10:133-40.
Nfambi J, Bbosa GS, Sembajwe LF, Gakunga J, Kasolo JN. Immunomodulatory activity of methanolic leaf extract of Moringa oleifera
in Wistar albino rats. J Basic Clin Physiol Pharmacol 2015;10:603-11.
Jayanthi M, Garg SK, Yadav P, Bhatia AK, Goel A. Some newer marker phytoconstituents in methanolic extract of Moringa oleifera
leaves and evaluation of its immunomodulatory and splenocytes proliferation potential in rats. Indian J Pharmacol 2015;10:518-23.
Saralaya MG, Patel P, Patel M, Roy SP, Patel AN. Antidiarrheal activity of methanolic extract of Moringa oleifera
Lam. roots in experimental animal models. Int J Pharm Res 2010;10:35-9.
Lakshminarayana M, Shivkumar H, Rimaben P, Bhargava VK. Antidiarrhoeal activity of leaf extract of Moringa oleifera
in experimentally induced diarrhoea in rats. Int J Phytomed 2011;10:68-74.
Choudhury S, Sharan L, Sinha MP. Anti-diarrhoeal potentiality of leaf extracts of Moringa oleifera
. Br J Appl Sci Technol 2013;10:1086-96.
Ali A, Akhtar N, Khan MS, Khan MT, Ullah A, Shah MI. Effect of Moringa oleifera
on undesirable skin sebum secretions of sebaceous glands observed during winter season in humans. Biomed Res 2013;10:127-30.
Raguindin PF, Dans LF, King JF. Moringa oleifera
as a galactagogue. Breastfeed Med 2014;10:323-4.
Medhi HN, Khanikor LC, Lahon PM, Barua CC. Analgesic, anti-inflammatory and local anesthetic activity of Moringa
in laboratory animals. Int J Pharmacogn 1996;10:207-12.
Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera
leaf extracts inhibit 6beta-hydroxylation of testosterone by cyp3a4. J Infect Dev Ctries 2008;10:379-83.
[Figure 1], [Figure 2]
[Table 1], [Table 2]