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ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 8  |  Page : 556-561

Anticalculi activity of apigenin and celery (Apium graveolens L.) extract in rats induced by ethylene glycol–ammonium chloride


1 Department of Pharmaceutics and Pharmaceutical Technology, Padjadjaran University, Sumedang, Indonesia; Department of Pharmaceutics and Pharmacetical Technology, Salsabila Institute of Health Sciences, Serang, Indonesia
2 Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Sumedang, Indonesia
3 Department of Pharmaceutics and Pharmaceutical Technology, Padjadjaran University, Sumedang, Indonesia

Correspondence Address:
Dr. Taofik Rusdiana
Department of Pharmaceutics and Pharmaceutical Technology, Padjadjaran University, Jl. Raya Bandung, Sumedang KM 21, Jatinangor, West Java, Jawa Barat.
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpbs.JPBS_202_19

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Objective: Kidney stones (nephrolithiasis) is one of the kidney diseases in the form of stones that contain crystal and organic matrix components. It is one of the most common diseases of the urinary tract. Calcium stone is the most important type of stone (80%) found in the case of kidney stones. Celery (Apium graveolens L.) is a plant rich in flavonoids, which can break down calcium crystals. Apigenin is considered to be one of the main flavonoids because of its presence and abundance in celery. This research aimed to compare the anticalculi effect of apigenin with that of celery extract. Materials and Methods: Wistar albino rats were given ethylene glycol 0.75% (vol/vol) and ammonium chloride 2% (wt/vol) orally for 7 days in all groups to induce hyperoxaluria and Rats treated by Apigenin at doses 1.2, 2.4, and 4.8 mg/kg of rat body weight and celery extract at doses of 200, 400, and 600 mg/kg of rat body weight as anticalculi. Measurements of calcium levels in the kidneys and urine of rats was obtained using atomic absorption spectroscopy. Data obtained were statistically analyzed with the IBM SPSS by ANOVA Method version 21.0 probability value < 0.05 was considered significant. Result: The results showed that both apigenin and celery extracts caused kidney stone to decay. From the data Apigenin and celery showed that calcium level in urine there were significant differences (p value < 0.05) in treated group from negative control group but calcium level in kidney there were not significant differences (p value > 0.05). Conclusion: Celery extract has better ability to break down kidney stones than apigenin.


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