Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 479  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


ORIGINAL ARTICLE
Year : 2020  |  Volume : 12  |  Issue : 5  |  Page : 382-388

Expression of survivin in oral potentially malignant disorders: An immunohistochemical study


Department of Oral Pathology and Microbiology, Best Dental Science College and Hospital, Madurai, Tamil Nadu, India

Correspondence Address:
Venkatraman R Rajanna
Department of Oral Pathology and Microbiology, Best Dental Science College and Hospital, Ultra Nagar, Madurai–Chennai Highway, Madurai, Tamil Nadu.
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpbs.JPBS_114_20

Rights and Permissions

Aim: The aim of this study was to compare the immunohistochemical expression of survivin in oral potentially malignant disorders (OPMDs) and evaluate its prognostic significance among oral leukoplakia (OL), oral submucous fibrosis (OSMF), and oral lichen planus (OLP). Materials and Methods: The study material consisted of 60 formalin-fixed paraffin-embedded tissue samples: 15 cases each of OL, OSMF, OLP, and normal oral mucosal epithelium as control. Survivin expression was analyzed immunohistochemically, and data analysis was accomplished using Statistical Package for Social Sciences, version 22.0 (SPSS Inc., Chicago, IL). Fisher’s chi-square test was opted to compare the study groups. Results: Survivin was expressed in all the OPMDs including OL, OSMF, and OLP, but was absent in normal oral tissue samples. Higher immunoreactivity and survivin staining was observed in OLP compared to OL and OSMF whereas OL showed a significant difference in the distribution of survivin immunoexpression against OLP. An increased nuclear expression of survivin along with distribution in the basal and parabasal layers was evident in all OPMDs. Conclusion: Survivin was expressed more in OLP in comparison to OSMF and OLP, indicating unfavorable prognosis. OL showed increased expression in comparison to OSMF, showing unfavorable prognosis. On the basis of this study, it was concluded that survivin may be used as an important diagnostic and prognostic marker for OPMDs.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed58    
    Printed0    
    Emailed0    
    PDF Downloaded6    
    Comments [Add]    

Recommend this journal