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ORIGINAL ARTICLE
Year : 2020  |  Volume : 12  |  Issue : 5  |  Page : 560-563

Bone sparing effects of bisphosphonates in cyclosporine-induced alveolar bone loss: An animal study


1 Department of Periodontics, Yenepoya Dental College, Mangalore, Karnataka, India
2 Department of Conservative Dentistry and Endodontics, GDC, Bangalore, Karnataka, India
3 Department of Conservative Dentistry and Endodontics, Yenepoya Dental College, Mangalore, Karnataka, India

Correspondence Address:
Aravind R Kudva
Department of Conservative Dentistry and Endodontics, Yenepoya Dental College, Yenepoya University, University Road, Deralakatte, Mangalore, Karnataka.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpbs.JPBS_171_20

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Various pharmacological agents are known to create an imbalance in the normal physiology of bone remodeling. Cyclosporine-A (Cs-A) is one of the drugs that is widely used in transplantation and has its main side effect as gingival hyperplasia and alveolar bone loss by their action on the inflammatory mediators. Bisphosphonates are a new class of drugs that inhibit bone resorption by decreasing the osteoclast activity and number. The aim of this study was to evaluate the effect of concomitant administration of alendronate on Cs-A-induced alveolar bone loss in a rat model.


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