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RESEARCH ARTICLE
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Acetylcholinesterase inhibitory potentiality of some minor fruits of West Bengal, India


 Department of Botany, Phytochemistry and Pharmacognosy Research Laboratory, University of Calcutta, 35, Kolkata, West Bengal, India

Correspondence Address:
Susmita Das,
Department of Botany, Phytochemistry and Pharmacognosy Research Laboratory, University of Calcutta, 35, Kolkata, West Bengal
India
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Source of Support: None, Conflict of Interest: None

Aim: The research on potential acetylcholinesterase (AChE) inhibitors from natural sources is always on demand as AChE inhibitors are used to treat Alzheimer's disease. The current study is focused on investigating the AChE inhibitory property of a number of indigenous and less popular fruits of West Bengal, India. Total phenol and flavonoid content of these fruits were also estimated. Materials and Methods: Aqueous extracts of nineteen different species of fruits were used in the study for evaluating AChE inhibitory activity. Results: Among the 19 fruit analyzed for their AChE inhibitory properties, aqueous extracts of only six fruits, e.g., Achras sapota, Feronia elephantum, Lepisanthes rubiginosa, Physalis peruviana, Trapa bispinosa, and Zizyphus mauritiana inhibited AChE enzyme. A. sapota showed the highest AChE inhibitory activity (IC 50 value = 1.17 mg/mL). The AChE inhibitory activities of the other fruit extracts were observed in the following order: L. rubiginosa, F. elephantum, T. bispinosa, Zizyphus jujuba and lowest in P. peruviana. The IC 50 value of established drug physostigmine for AChE inhibition was found to be 0.391 mg/mL. Conclusions: All the above studied fruits may have beneficial neuroprotective properties. Further in vivo and phytochemical studies are required to be carried out.


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