Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 709  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


 
ORIGINAL ARTICLE
Ahead of Print

An experimental evaluation of adaptogenic potential of standardized Epipremnum aureum leaf extract


 Department of Pharmacology, Faculty of Pharmacy, Lincoln University College, Petaling Jaya, Selangor, Malaysia

Correspondence Address:
Sreemoy Kanti Das,
Department of Pharmacology, Faculty of Pharmacy, Lincoln University College, Petaling Jaya, Selangor
Malaysia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Background: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential. Materials and Methods: For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E.aureumextract. Diazepam (5 mg/kg) was taken as a reference standard. Urinary vanillylmandelic acid (VMA) and ascorbic acid were selected as noninvasive biomarkers to assess the anti-stress activity and plasma cortisol, blood ascorbic acid, and weight of adrenal were measured. The 24 h urinary excretion of VMA and ascorbic acid were determined by spectrophotometric methods in all groups under normal and stressed conditions. The hematological parameters (neutrophils, lymphocytes, and eosinophils) were also determined. Results: Administration of E.aureumat doses of 400 and 600 mg/kg wasfound to be effective in inhibiting the stress induced urinary biochemical changes in a dose-dependent manner. Treatment with E. aureum extract prevents the rise in blood ascorbic acid and plasma cortisol. Moreover, the extract prevented the increase in weight of adrenal gland also significantly increased the anoxia stress tolerance time. Dose-dependent significant reduction in white blood cell count was observed in anoxic stress tolerance test as compared to stressed group. Conclusion: Hence, the present study provides scientific support for the positiveadaptogenic effect of E. aureum extract.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Das SK
    -  Mustapha MS
    -  Sengupta P
    -  Sarker MM
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed975    
    PDF Downloaded36    

Recommend this journal