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Comparative study of changes in renal and electrolyte profiles induced by liposomal doxorubicin versus conventional doxorubicin-based regimens in cancer patients


1 Department of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, Lahore, Pakistan; Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia
2 Department of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, Lahore, Pakistan
3 Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia
4 Department of Pharmacy Services, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

Correspondence Address:
Fahad Saleem,
Department of Pharmacy Services, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Source of Support: None, Conflict of Interest: None

Objective: Anticancer agents are extensively used to treat cancer as a part of chemotherapy protocols. However, while producing therapeutic effects, these drugs exert deleterious effects by bringing structural and physiological changes in vital body organs. The objective of this study was to evaluate whether the liposomal doxorubicin (LD) and conventional doxorubicin (CD) affect the renal function tests (RFTs) and electrolyte profiles of the patients under treatment. Patients and Methods: This multicenter retrospective observational study was conducted to compare the relative safety of the LD and CD on renal and electrolyte profiles of cancer patients. Clinical data of 92 cancer patients were collected from specialized cancer hospitals through hospital information system. Baseline renal and electrolyte values were assessed before initiating drug therapy including blood urea nitrogen, creatinine, sodium, potassium, chloride, and bicarbonate. All laboratory findings were re-evaluated after every chemotherapy during cycle 1, cycle 2, cycle 3, and cycle 4 for 21 days in case of CD and for 30 days in case of LD, respectively. SPSS version 21.0 (Armonk, NY), IBM corporation was used for data analysis. Results: Fifty-five patients (59.78%) were treated with CD whereas 37 (40.22%) patients were on LD therapy. Majority of the patients (94.56%) under treatment were females. The paired t-test revealed nonsignificant association among conventional and LD formulations (P > 0.05). Conclusion: It is concluded that both conventional and LD formulations do not significantly disturb the RFTs and electrolyte balance in clinically ill cancer patients.


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