Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 1  |  Page : 44--46

Screening of nutrient parameters for mevastatin production by Penicillium citrinum MTCC 1256 under submerged fermentation using the Plackett-Burman design


Ajaz Ahmad, Bibhu Prasad Panda, Mohd. Mujeeb 
 Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062, India

Correspondence Address:
Mohd. Mujeeb
Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062
India

Objective : Mevastain, an HMG-CoA reductase inhibitor produced by Penicillium citrinum. The Placket-Burman experimental design was used to identify the important nutrients influencing the production of mevastatin by Penicillium citrinum MTCC 1256 under submerged fermentation. Materials and Methods : Nine nutritional parameters, such as, glucose, glycerol, arrowroot, oats, urea, peptone, yeast extract, MgSO 4 .7H 2 O, and CaCl 2 .2H 2 O were screened by Placket-Burman experimental design in 12 experimental run. Results : Nine nutritional parameters, glucose, glycerol, arrowroot, oats, urea, peptone, yeast extract, MgSO 4 .7H 2 O, and CaCl 2 .2H 2 O contributed with 0.8114%, 24.0390%, 2.2786%, 0.1491%, 0.5608%, 47.5029%, 6.8092 %, 4.0980%, 10.5823% respectively towards mevastatin production by Penicillium citrinum under submerged fermentation. Conclusion : Among the nine nutrient components glycerol, peptone, yeast extract, MgSO 4 .7H 2 0, and CaCl 2 .2H 2 O contributed to a large extent, urea had little impact, while glucose, oats, and arrowroot contributed moderately on production of mevastatin.


How to cite this article:
Ahmad A, Panda BP, Mohd. Mujeeb. Screening of nutrient parameters for mevastatin production by Penicillium citrinum MTCC 1256 under submerged fermentation using the Plackett-Burman design.J Pharm Bioall Sci 2010;2:44-46


How to cite this URL:
Ahmad A, Panda BP, Mohd. Mujeeb. Screening of nutrient parameters for mevastatin production by Penicillium citrinum MTCC 1256 under submerged fermentation using the Plackett-Burman design. J Pharm Bioall Sci [serial online] 2010 [cited 2020 Mar 29 ];2:44-46
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=1;spage=44;epage=46;aulast=Ahmad;type=0