Journal of Pharmacy And Bioallied Sciences

COMMENTARY
Year
: 2011  |  Volume : 3  |  Issue : 4  |  Page : 469-

Limitation of EPR: A thing to be noted


Viroj Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok - 10160
Thailand




How to cite this article:
Wiwanitkit V. Limitation of EPR: A thing to be noted.J Pharm Bioall Sci 2011;3:469-469


How to cite this URL:
Wiwanitkit V. Limitation of EPR: A thing to be noted. J Pharm Bioall Sci [serial online] 2011 [cited 2019 Dec 6 ];3:469-469
Available from: http://www.jpbsonline.org/text.asp?2011/3/4/469/90099


Full Text

Editor, I read the recent study on "EPR as a tool for the evaluation of novel lyophilized blood products as absorbents for chemical gas masks" with a great interest. [1] Ivanov et al. concluded that "EPR can play a role in the evaluation of material for gas masks." [1] I agree that the EPR is a good technique. However, I would like to note that there are some concerns on this technique. Jeschke and Polyhach noted that "The sensitivity of the technique and the reliability of the measured distance distribution depend on careful optimization of the experimental conditions and procedures for data analysis." [2] Despite a good EPR, the error can still be at 0.1 nm. [3]

References

1Ivanov V, Arora R, Hadjiiliev V, Stoyanova R, Ruseva R, Nikolov R, et al. EPR as a tool for the evaluation of novel lyophilized blood products as absorbents for chemical gas masks. J Pharm Bioallied Sci 2011;3:318-9.
2Jeschke G, Polyhach Y. Distance measurements on spin-labelled biomacromolecules by pulsed electron paramagnetic resonance. Phys Chem Chem Phys 2007;9:1895-910.
3Reginsson GW, Schiemann O. Pulsed electron-electron double resonance: Beyond nanometre distance measurements on biomacromolecules. Biochem J 2011;434:353-63.