Journal of Pharmacy And Bioallied Sciences

SHORT COMMUNICATION
Year
: 2011  |  Volume : 3  |  Issue : 4  |  Page : 543--545

Blue cures blue but be cautious


Pranav Sikka1, VK Bindra2, Seema Kapoor3, Vivek Jain4, KK Saxena1 
1 Department of Pharmacology, LLRM Medical College, Muradnagar (Ghaziabad), India
2 Department of Medicine, IDST, Muradnagar (Ghaziabad), India
3 Departments of Oral Pathology and Microbiology, ITS- CDSR, Muradnagar (Ghaziabad), India
4 Consultant dermatologist, Lokpriya Hospital, Meerut, Uttar Pradesh, India

Correspondence Address:
Pranav Sikka
Department of Pharmacology, LLRM Medical College, Muradnagar (Ghaziabad)
India

Methemoglobinemia is a disorder characterized by the presence of >1% methemoglobin (metHb) in the blood. Spontaneous formation of methemoglobin is normally counteracted by protective enzyme systems, for example, nicotinamide adenine dinucleotide phosphate (NADPH) methemoglobin reductase. Methemoglobinemia is treated with supplemental oxygen and methylene blue (1-2 mg/kg) administered slow intravenously, which acts by providing an artificial electron acceptor for NADPH methemoglobin reductase. But known or suspected glucose-6-phosphate dehydrogenase (G6PD) deficiency is a relative contraindication to the use of methylene blue because G6PD is the key enzyme in the formation of NADPH through pentose phosphate pathway and G6PD-deficient individuals generate insufficient NADPH to efficiently reduce methylene blue to leukomethylene blue, which is necessary for the activation of the NADPH-dependent methemoglobin reductase system. So, we should be careful using methylene blue in methemoglobinemia patient before G6PD levels.


How to cite this article:
Sikka P, Bindra V K, Kapoor S, Jain V, Saxena K K. Blue cures blue but be cautious.J Pharm Bioall Sci 2011;3:543-545


How to cite this URL:
Sikka P, Bindra V K, Kapoor S, Jain V, Saxena K K. Blue cures blue but be cautious. J Pharm Bioall Sci [serial online] 2011 [cited 2020 Aug 8 ];3:543-545
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=4;spage=543;epage=545;aulast=Sikka;type=0