Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 4  |  Issue : 1  |  Page : 66--69

Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama


Cristopher A Boya1, Liuris Herrera2, Hector M Guzman3, Marcelino Gutierrez1 
1 Center for Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, Republic of Panama
2 Center for Cellular and Molecular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, Republic of Panama
3 Smithsonian Tropical Research Institute Balboa, Ancon, Republic of Panama

Correspondence Address:
Marcelino Gutierrez
Center for Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge
Republic of Panama

Aim: This study was designed for isolating and characterizing antiplasmodial compounds from marine octocoral-associated bacteria. Materials and Methods: The organic extract of the Bacillus sp. was subjected to purification using several chromatography techniques guided by bioassays to yield three isocoumarin derivatives (1-3). Chemical structures of the compounds were elucidated on the basis of HRMS spectra and NMR spectroscopy. The antiplasmodial activity of the isolated compounds was evaluated in vitro against the chloroquine-resistant Plasmodium falciparum strain W2. Results: Isolated compounds were identified as bacilosarcin A (1), AI77-F (2), and AI77-H (3). Bacilosarcin A (1) displayed a low micromolar activity (IC 50 = 2.2 μM) against P. falciparum while compounds 2 and 3 showed no activity. Conclusions: Bacilosarcin A was found to be responsible for the antiplasmodial activity observed in the crude extract obtained from the Bacillus sp.


How to cite this article:
Boya CA, Herrera L, Guzman HM, Gutierrez M. Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama.J Pharm Bioall Sci 2012;4:66-69


How to cite this URL:
Boya CA, Herrera L, Guzman HM, Gutierrez M. Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama. J Pharm Bioall Sci [serial online] 2012 [cited 2020 Aug 9 ];4:66-69
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=1;spage=66;epage=69;aulast=Boya;type=0