Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 6  |  Issue : 3  |  Page : 185--191

Reduction in mortality and teratogenicity following simultaneous administration of folic acid and vitamin E with antiepileptic, antihypertensive and anti-allergic drugs


Shahana Wahid1, Rafeeq Alam Khan2, Zeeshan Feroz3 
1 Department of Pharmacology, University of Karachi, Karachi 75270, Pakistan
2 Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, KSA
3 Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, KSA

Correspondence Address:
Rafeeq Alam Khan
Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah
KSA

Aim: The present study was designed to evaluate the teratogenic effects on breeding pattern in mice following administration of lamotrigine (LT) and levetiracetam (LV) and its combination with anti-hypertensive and anti-allergic drugs. Moreover, possibility of decrease in teratogenic effect was also evaluated upon simultaneous administration of these combinations with folic acid or vitamin E. Materials and Methods: The study was carried out on mature female mice housed in polycarbonate breeding cages. Drugs were administered continuously till the birth of neonates and pups were examined for any teratogenic potential of drugs. Results: The results of the study reveals that teratogenic effects of lamotrigine, methyldopa and loratadine (LTMLO) combination were seems to be reduced upon simultaneous administration with folic acid, while addition of vitamin E was found to be more effective in reducing the mortality rate of levetiracetam, methyldopa and loratadine combination. Conclusion: Teratogenic effects of LTMLO combination were better prevented by folic acid. However, further studies on large number of animals and humans are required before reaching to definite conclusion.


How to cite this article:
Wahid S, Khan RA, Feroz Z. Reduction in mortality and teratogenicity following simultaneous administration of folic acid and vitamin E with antiepileptic, antihypertensive and anti-allergic drugs.J Pharm Bioall Sci 2014;6:185-191


How to cite this URL:
Wahid S, Khan RA, Feroz Z. Reduction in mortality and teratogenicity following simultaneous administration of folic acid and vitamin E with antiepileptic, antihypertensive and anti-allergic drugs. J Pharm Bioall Sci [serial online] 2014 [cited 2020 Sep 21 ];6:185-191
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2014;volume=6;issue=3;spage=185;epage=191;aulast=Wahid;type=0