Journal of Pharmacy And Bioallied Sciences

DENTAL SCIENCE - ORIGINAL ARTICLE
Year
: 2014  |  Volume : 6  |  Issue : 5  |  Page : 165--170

Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment


V Venkataramana1, S Sathesh Kumar2, B Vishnuvardhan Reddy3, A Sreekanth Cherukuri3, K Raja Sigamani4, G Chandrasekhar1 
1 Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, India
2 Department of Orthodontics, JKKN Dental College, Komarapalyam, Namakkal, India
3 Department of Orthodontics, G. Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, India
4 Department of Orthodontics Rajah Muthiah Dental College, Annamalai University, Chidambaram, Tamilnadu, India

Correspondence Address:
Dr. K Raja Sigamani
Department of Orthodontics Rajah Muthiah Dental College, Annamalai University, Chidambaram, Tamilnadu
India

Introduction: Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits. Materials and Methods: Twenty rabbits were divided into two groups- DQ10DQ served as Group-1 (control) and other DQ10DQ as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1 st , 7 th , and 14 th day of the experiment. A total of DQ40DQ lateral cephalograms were taken from both groups on the 1 st and 21 st day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animalSQs radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale. Results: The StudentSQs t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001). Conclusion: The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.


How to cite this article:
Venkataramana V, Kumar S S, Reddy B V, Cherukuri A S, Sigamani K R, Chandrasekhar G. Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment.J Pharm Bioall Sci 2014;6:165-170


How to cite this URL:
Venkataramana V, Kumar S S, Reddy B V, Cherukuri A S, Sigamani K R, Chandrasekhar G. Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment. J Pharm Bioall Sci [serial online] 2014 [cited 2020 Sep 25 ];6:165-170
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2014;volume=6;issue=5;spage=165;epage=170;aulast=Venkataramana;type=0