Journal of Pharmacy And Bioallied Sciences

REVIEW ARTICLE
Year
: 2020  |  Volume : 12  |  Issue : 2  |  Page : 112--123

Clinical review of acute, recurrent, and chronic pancreatitis: Recent updates of 2013–2019 literature


Noor Sadiq, Syed Wasif Gillani, Dalia Al Saeedy, Joud Rahmoun, Durah Shaban, Kholoud Kotait, Shahin Javaheri 
 Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, UAE

Correspondence Address:
Dr. Syed Wasif Gillani
Department of Pharmacy Practice, College of Pharmacy Gulf Medical University, Ajman
UAE

The increasing prevalence of pancreatic disorders worldwide has provided challenges in its clinical care and management. This review was aimed to evaluate recent literature on diagnosis, treatment, and management of acute pancreatitis (AP), recurrent acute pancreatitis (RAP), as well as chronic pancreatitis (CP) documented during the past 5–6 years. An extensive literature review was carried out based on studies within the last 6 years (2013–2019). Articles were selected based on updates and therapeutic management. Critical appraisal of literature was performed using the Mixed Methods Appraisal Tool (MMAT), and a PRISMA flowchart was used to avoid bias. The study identified recent updates on the prophylactic treatment in preventing RAP. The risk factors and the therapeutic management options were evaluated and discussed. The findings show that although many lifesaving new protocols are available for implementation in clinical practice, current literature lacks detailed and comprehensive guidelines that cover special populations and comorbidities. The literature evaluated showed that eight genes were involved in pancreatitis, CASR, CFTR, CLDN2, CPA1, CTRC, PRSS1, SBDS, and SPINK1, but the most common gene implicated was found to be CFTR, at 11%. Therefore, it is recommended that a comprehensive guideline should be formulated to facilitate the diagnosis, management, treatment, and prophylactic measures of pancreatic disease. This could in turn reduce disease complications and hospitalization time, and improve clinical practice for management of pancreatitis.


How to cite this article:
Sadiq N, Gillani SW, Al Saeedy D, Rahmoun J, Shaban D, Kotait K, Javaheri S. Clinical review of acute, recurrent, and chronic pancreatitis: Recent updates of 2013–2019 literature.J Pharm Bioall Sci 2020;12:112-123


How to cite this URL:
Sadiq N, Gillani SW, Al Saeedy D, Rahmoun J, Shaban D, Kotait K, Javaheri S. Clinical review of acute, recurrent, and chronic pancreatitis: Recent updates of 2013–2019 literature. J Pharm Bioall Sci [serial online] 2020 [cited 2020 Jul 15 ];12:112-123
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=2;spage=112;epage=123;aulast=Sadiq;type=0