Journal of Pharmacy And Bioallied Sciences

REVIEW ARTICLE
Year
: 2020  |  Volume : 12  |  Issue : 2  |  Page : 94--101

Current topical trends and novel therapeutic approaches and delivery systems for oral mucositis management


Anmar Al-Taie1, Athmar D Al-Shohani2, Zahraa Albasry3, Ataa Altaee3 
1 Pharmacy Department, Faculty of Pharmacy, Girne American University, North Cyprus, Turkey
2 Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
3 Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq

Correspondence Address:
Dr. Anmar Al-Taie
Pharmacy Department, Faculty of Pharmacy, Girne American University, 99428 Kyrenia, North Cyprus, Mersin 10
Turkey

Oral mucositis (OM) is an extremely serious and challenging complication of chemoradiotherapy, which may limit the efficacy of cancer treatment. Complications related to OM include potential nutrition impairment, high economic burden, and negative impacts on patients’ quality of life. Current therapeutic options with local traditional pharmaceutical formulations are largely focused on controlling symptoms, and only few agents are available for treatment. Several local supportive and palliative agents are used for the prevention of OM; however, a standard treatment for the disease has not been confirmed yet. The efficacy of treatment could be improved through the introduction of new medical agents with updated dosage forms that can enhance and optimize local drug delivery and create greater therapeutic effects with fewer side effects. The focus of this review was to provide clear and direct information about the currently available topical therapeutic agents in clinical practice used to cure and/or reduce the incidence of ulcerative symptoms of OM, excluding the associated pain and other coexisting complications such as bacterial and fungal infections. The review also provides recent evidences regarding agents that could be used as promising novel therapies in updated local delivering systems. This will support further encouraging options and approaches for the management of OM and will improve compliance that could be translated in better disease control and survival.


How to cite this article:
Al-Taie A, Al-Shohani AD, Albasry Z, Altaee A. Current topical trends and novel therapeutic approaches and delivery systems for oral mucositis management.J Pharm Bioall Sci 2020;12:94-101


How to cite this URL:
Al-Taie A, Al-Shohani AD, Albasry Z, Altaee A. Current topical trends and novel therapeutic approaches and delivery systems for oral mucositis management. J Pharm Bioall Sci [serial online] 2020 [cited 2020 Sep 18 ];12:94-101
Available from: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=2;spage=94;epage=101;aulast=Al-Taie;type=0