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  Indian J Med Microbiol
 

Figure 3: Effect of exogenous supplementation of N-acetylcysteine (NAC) along with adsorbed ascites fluid (ad-AF) treatment on the alterations of phase I and phase II biotransformation enzymes activities in liver of tumor bearers and treated mice. Animals in each groups were transplanted with 1×106 EAT cells i.p. Group I (Tumor Control) was administrated 0.1mL of normal saline, Group II (Tumor Experimental) received 0.1mL of ad-AF, whereas Group III (Tumor Experimental + NAC) was treated with 0.1mL of ad-AF and NAC (0.1mL) i.p. on alternate days right from the day of tumor transplantation (day 0). Animals were sacrificed by cervical dislocation on 18th day post-tumor transplantation. Activities of biotransformation enzymes were measured in liver. First group of bars represent the activity of aminopyrine-N-demethylase (AD), second group of bars represent the activity of aniline hydroxylase (AH), whereas the third group of bars represent the activity of glutathione-S-transferase (GST) in liver. Values are mean ± SE of five animals in each group. *P<0.05, **P<0.005

Figure 3: Effect of exogenous supplementation of <i>N</i>-acetylcysteine (NAC) along with adsorbed ascites fluid (ad-AF) treatment on the alterations of phase I and phase II biotransformation enzymes activities in liver of tumor bearers and treated mice. Animals in each groups were transplanted with 1×10<sup>6</sup> EAT cells <i>i.p.</i> Group I (Tumor Control) was administrated 0.1mL of normal saline, Group II (Tumor Experimental) received 0.1mL of ad-AF, whereas Group III (Tumor Experimental + NAC) was treated with 0.1mL of ad-AF and NAC (0.1mL) <i>i.p.</i> on alternate days right from the day of tumor transplantation (day 0). Animals were sacrificed by cervical dislocation on 18th day post-tumor transplantation. Activities of biotransformation enzymes were measured in liver. First group of bars represent the activity of aminopyrine-<i>N</i>-demethylase (AD), second group of bars represent the activity of aniline hydroxylase (AH), whereas the third group of bars represent the activity of glutathione-S-transferase (GST) in liver. Values are mean ± SE of five animals in each group. *<i>P</i><0.05, **<i>P</i><0.005