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Year : 2010  |  Volume : 2  |  Issue : 2  |  Page : 144-147

Effect of soybean supplementation on the memory of alprazolam-induced amnesic mice

1 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar; Rajendra Institute of Technology & Sciences, Hisar Road, Sirsa, Haryana, India
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, India

Correspondence Address:
Milind Parle
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.67001

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Soybean, Glycine max (L.) Merr. (Leguminoseae), is known as golden bean. It contains vegetable protein, oligosaccharide, dietary fiber, vitamins, isoflavones and minerals. Earlier studies have demonstrated a cholesterol lowering, skin protective, antitumour, antidiabetic and antioxidative potential of soybean. Soy isoflavones are also utilized as estrogen replacement therapy in postmenopausal women. The present study was undertaken to investigate the effect of soybean on memory of mice when consumed along with diet. Soybean was administered chronically for 60 consecutive days as three soybean diets viz. Soy2, Soy5, Soy10. These diet contains soybean in normal diet at concentration of 2%, 5%, 10% w/w respectively. Passive avoidance paradigm and elevated plus maze served as exteroceptive behavioral models for testing memory. Alprazolam (0.5 mg/kg; i.p.) induced amnesia served as interoceptive behavioral model. The administration of soybean significantly reversed alprazolam-induced amnesia in a dose-dependent manner as indicated by the increased step down latency of mice using passive avoidance paradigm and increased transfer latency using elevated plus maze. Theses results suggest that consumption of soybean in diet may not only improve memory but also reverse the memory deficits, owing to its multifarious activities. It would be worthwhile to explore the potential of this nutrient in the management of Alzheimer's disease.

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