ORIGINAL/BRIEF

Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 92-94

Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A

A Lodha¹, M Lodha², A Patel³, J Chaudhuri³, J Dalal³, M Edwards², D Douroumis^2
1 Gujarat Liqui Pharmacaps Pvt. Ltd., 662-666, GIDC, Waghodia, Baroda, Gujarart, India; University of Greenwich, London, UK
² University of Greenwich, London, UK
³ Gujarat Liqui Pharmacaps Pvt. Ltd., 662-666, GIDC, Waghodia, Baroda, Gujarart, India

Correspondence Address:
A Lodha
Gujarat Liqui Pharmacaps Pvt. Ltd., 662-666, GIDC, Waghodia, Baroda, Gujarart, India; University of Greenwich, London, UK

Source of Support: None, Conflict of Interest: None

Check

DOI: 10.4103/0975-7406.94153

Abstract

Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and inorganic groups. Silica nano-particles were synthesized by chemical methods from tetraethylorthosilicate (TEOS), methanol (CH3OH) and deionised water in the presence of sodium hydroxide as catalyst at 80°C temperature. The nature and morphology of particles was investigated by scanning electron microscopy (SEM), N2 adsorption/desorption method using BET instrument and X-ray diffraction (XRD). Silica nanoparticles are applicable to a wide range of therapeutic entities from small molecule to peptides and proteins including hydrophobic and hydrophilic entities. Drug loading does not require chemical modification of the molecule; there are no changes in the drug structure or activity after loading and subsequent release of the drug. Thus, well suited to solve formulation problems associated with hydrophobic drugs such as peptide and protein drugs like cyclosporine A. Silica nanoparticles improved the solubility of poorly water soluble drugs and enhanced the absorption and bioavailability of these compounds.

Keywords: Silica, nanoparticle, cyclosporine

This article has been cited by 1 Synthesis and characterization of mesoporous SiO2 nanoparticles for bio medical applications VigneshKrishnan, M Suresh, T Kalaivani IOP Conference Series: Materials Science and Engineering. 2022; 1219(1): 012038 [Pubmed] | [DOI] 2 Mesoporous Silica Nanoparticles Carrying MicroRNA-124 to Target P2Y12 Facilitates Cerebral Angiogenesis in Lacunar Cerebral Infarction Through Stem Cell Factor/c-Kit Signaling Pathway Jian Wang, Bo Zheng, Shu Yang, Jian Fan, Hao Sun, Jianhong Wang Journal of Biomedical Nanotechnology. 2022; 18(1): 218 [Pubmed] | [DOI] 3 Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer Fariha Kanwal, Mingming Ma, Muhammad Fayyaz ur Rehman, Fahim-ullah Khan, Shai E. Elizur, Aima Iram Batool, Chi Chiu Wang, Tahira Tabassum, Changrui Lu, Yao Wang Frontiers in Molecular Biosciences. 2022; 8 [Pubmed] | [DOI] 4 Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect Alex N. Frickenstein, Jordan M. Hagood, Collin N. Britten, Brandon S. Abbott, Molly W. McNally, Catherine A. Vopat, Eian G. Patterson, William M. MacCuaig, Ajay Jain, Keisha B. Walters, Lacey R. McNally Pharmaceutics. 2021; 13(4): 570 [Pubmed] | [DOI] 5 Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature Kah Min Yap, Mahendran Sekar, Shivkanya Fuloria, Yuan Seng Wu, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Vetriselvan Subramaniyan, Chandrakant Kokare, Pei Teng Lum, M Yasmin Begum, Shankar Mani, Dhanalekshmi Unnikrishnan Meenakshi, Kathiresan V Sathasivam, Neeraj Kumar Fuloria International Journal of Nanomedicine. 2021; Volume 16: 7891 [Pubmed] | [DOI] 6 Investigation of hemolysis and antibacterial analysis of curcumin-loaded mesoporous SiO2 nanoparticles Vignesh Krishnan, G. Devanand Venkatasubbu, T. Kalaivani Applied Nanoscience. 2021; [Pubmed] | [DOI] 7 Harnessing the nano-bio interface: Application of membrane coating to long acting silica particles Puneet Tyagi European Journal of Pharmaceutics and Biopharmaceutics. 2021; 158: 382 [Pubmed] | [DOI] 8 Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells Vy Anh Tran, Van Giau Vo, Kyuhwan Shim, Sang-Wha Lee, Seong Soo A An International Journal of Nanomedicine. 2020; Volume 15: 7667 [Pubmed] | [DOI] 9 Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application Nurul Syahira Zaharudin, Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Khairulazhar Jumbri Journal of Saudi Chemical Society. 2020; 24(3): 289 [Pubmed] | [DOI] 10 Multipathway Antibacterial Mechanism of a Nanoparticle-Supported Artemisinin Promoted by Nitrogen Plasma Treatment Haiying Cui, Xiaochen Chen, Mei Bai, Dong Han, Lin Lin, Mingdong Dong ACS Applied Materials & Interfaces. 2019; 11(50): 47299 [Pubmed] | [DOI] 11 MCM-41 Nanoparticles for Brain Delivery: Better Choline-Esterase and Amyloid Formation Inhibition with Improved Kinetics Pawan K. Pandey, Ashok K. Sharma, Sarita Rani, Gaurav Mishra, Gopal Kandasamy, Ajit K. Patra, Monika Rana, Anuj K. Sharma, Awesh K. Yadav, Umesh Gupta ACS Biomaterials Science & Engineering. 2018; 4(8): 2860 [Pubmed] | [DOI] 12 Nanobiomaterials’ applications in neurodegenerative diseases Daniela Silva Adaya,Lucinda Aguirre-Cruz,Jorge Guevara,Emma Ortiz-Islas Journal of Biomaterials Applications. 2017; 31(7): 953 [Pubmed] | [DOI] 13 Engineering of mesoporous silica nanoparticles for release of ginsenoside CK and Rh2 to enhance their anticancer and anti-inflammatory efficacy: in vitro studies Priyanka Singh,Hina Singh,Verónica Castro-Aceituno,Sungeun Ahn,Yeon Ju Kim,Mohamed El-Agamy Farh,Deok Chun Yang Journal of Nanoparticle Research. 2017; 19(7) [Pubmed] | [DOI] 14 Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases Anindita Chowdhury,Selvaraj Kunjiappan,Theivendren Panneerselvam,Balasubramanian Somasundaram,Chiranjib Bhattacharjee International Nano Letters. 2017; [Pubmed] | [DOI] 15 Indocyanine green delivery systems for tumour detection and treatments Elena P. Porcu,Andrea Salis,Elisabetta Gavini,Giovanna Rassu,Marcello Maestri,Paolo Giunchedi Biotechnology Advances. 2016; [Pubmed] | [DOI] 16 Core–shell microcapsules of solid lipid nanoparticles and mesoporous silica for enhanced oral delivery of curcumin Sanghoon Kim,Roudayna Diab,Olivier Joubert,Nadia Canilho,Andreea Pasc Colloids and Surfaces B: Biointerfaces. 2016; 140: 161 [Pubmed] | [DOI] 17 Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol Natalie Summerlin,Zhi Qu,Naisarg Pujara,Yong Sheng,Siddharth Jambhrunkar,Michael McGuckin,Amirali Popat Colloids and Surfaces B: Biointerfaces. 2016; 144: 1 [Pubmed] | [DOI] 18 Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography Marie K. Gurka,Dillon Pender,Phillip Chuong,Benjamin L. Fouts,Alexander Sobelov,Molly W. McNally,Megan Mezera,Shiao Y. Woo,Lacey R. McNally Journal of Controlled Release. 2016; [Pubmed] | [DOI] 19 Pore ordering in mesoporous matrices induced by different directing agents Ana-Maria Putz,Savii Cecilia,Catalin Ianasi,Zoltán Dudás,Kinga Noémi Székely,Jiri Plocek,Paula Sfârloaga,Liviu Sacarescu,László Almásy Journal of Porous Materials. 2015; 22(2): 321 [Pubmed] | [DOI] 20 Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan Abdul Hakeem,Ruixue Duan,Fouzia Zahid,Chao Dong,Boya Wang,Fan Hong,Xiaowen Ou,Yongmei Jia,Xiaoding Lou,Fan Xia Chem. Commun.. 2014; 50(87): 13268 [Pubmed] | [DOI]