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DENTAL SCIENCE - ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 6  |  Page : 142-145

Collagen with simvastatin promotes cell metabolism in osteoblast-like SaOS-2 cells


1 Department of Periodontology and Oral Implantology, JKK Nataraja Dental College and Hospital, Komarapalyam, Namakkal Dist, India
2 Department of Pedodontic and Preventive Dentistry, JKK Nataraja Dental College and Hospital, Komarapalyam, Namakkal Dist, India
3 Department of Periodontology and Oral Implantology, Ragas Dental College and Hospital, Chennai, India
4 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India

Correspondence Address:
Sugumari Elavarasu
Department of Periodontology and Oral Implantology, JKK Nataraja Dental College and Hospital, Komarapalyam, Namakkal Dist
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.100221

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Background: Simvastatin (SMV) is one of the cholesterol-lowering pharmacological drugs. Recent studies demonstrate that it has a bone stimulatory effect. The present study was designed to investigate the effect of SMV along with collagen membrane on osteoblast-like SaOS-2 cells and also to standardize the dosage of SMV to be incorporated into the collagen membrane to achieve regeneration. Materials and Methods: SMV at doses of 0.5, 1, 1.5, and 2 mg was incorporated into the collagen membrane and cell metabolism was assessed by (3-[4,5-dimethylthiazolyl-2]-2,5-diphenyltetrazolium bromide) (MTT) assay for 24 h. Results: SMV enhanced cell metabolism dose dependently at 24-h time and the maximum effect was obtained at a concentration of 1.5 mg of SMV. Conclusion: These results indicate that collagen with 1.5 mg SMV exhibits positive effect on cell metabolism of human osteoblast-like SaOS-2 cells.


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