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Year : 2013  |  Volume : 5  |  Issue : 4  |  Page : 329-330  

Platelet concentrates: Regenerating the lost tissues

1 Department of Periodontology, D. J. Dental College, Modinagar, India
2 Department of Periodontology, Sardar Patel Institute of Dental and Medical Sciences, Lucknow, India
3 Department of Oral and Maxillofacial Surgery, I. T. S. Dental College, Greater Noida, Uttar Pradesh, India

Date of Web Publication19-Oct-2013

Correspondence Address:
Kriti Agarwal
Department of Periodontology, D. J. Dental College, Modinagar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.120074

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How to cite this article:
Agarwal K, Agarwal K, Kumar N. Platelet concentrates: Regenerating the lost tissues. J Pharm Bioall Sci 2013;5:329-30

How to cite this URL:
Agarwal K, Agarwal K, Kumar N. Platelet concentrates: Regenerating the lost tissues. J Pharm Bioall Sci [serial online] 2013 [cited 2021 Mar 1];5:329-30. Available from:


One of the recent promising innovations in dentistry is the use of platelet concentrates for the accelerated repair and regeneration of the soft and hard tissues. The use of platelet concentrates enhances the body's natural wound healing mechanisms. There has been considerable interest among the medical practitioners to develop some type of biologic glue that could achieve hemostasis and help in wound sealing. In the recent times, several new approaches have been developed to prepare them. They are based on autologous whole blood obtained immediate pre-operatively, which is then processed immediately into autologous concentrated platelet-rich plasma (PRP) or platelet rich fibrin (PRF). PRP is an autologous modification of fibrin glue [1] and is an autologous concentrate of human platelets in a small volume of plasma. This is achieved by the use of differential centrifugation in a conventional auto-transfusion machine. When this PRP is combined with thrombin and calcium chloride, platelet gel is created. [2] This product is a rich source of growth factors and is effective in accelerating significant tissue repair and regeneration. PRP works through the degranulation of the granules in platelets, which contain the synthesized and pre-packed growth factors. The two most important growth factors are platelet-derived growth factor, and transforming growth factor-β. Because PRP enhances osteoprogenitor cells in the host bone and in bone grafts, it has found clinical applications in bone defects, sinus lift augmentation, horizontal and vertical ridge augmentations, ridge preservation, periodontal/peri-implant defects, cyst enucleations/periapical surgeries, healing of extraction wounds, endodontic surgeries, ablative surgeries of the maxillo-facial region and blepharoplasty. PRF was first developed in France by Choukroun et al. [3] and is a second generation platelet concentrate. This technique requires neither anticoagulant nor bovine thrombin. PRF occurs in the form of platelet gel and promotes bone growth and maturation, promotes healing of wound and can be used in conjunction with the bone graft materials and can accelerate regeneration of tissues. PRF is considered a useful biomaterial and a number of authors have shown its importance in the treatment of periodontal defects, furcation and gingival recession. [4],[5] Though, the material is widely used by the clinicians all over the world because of its ease of preparation and cost effectiveness, more future long-term clinical trials are required to establish and understand its role completely.

   References Top

1.Whitman DH, Berry RL, Green DM. Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 1997;55:1294-9.  Back to cited text no. 1
2.Oz MC, Jeevanandam V, Smith CR, Williams MR, Kaynar AM, Frank RA, et al. Autologous fibrin glue from intraoperatively collected platelet-rich plasma. Ann Thorac Surg 1992;53:530-1.  Back to cited text no. 2
3.Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:299-303.  Back to cited text no. 3
4.Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: A randomized clinical trial. J Periodontol 2011;82:1396-403.  Back to cited text no. 4
5.Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, et al. Use of platelet-rich fibrin membrane following treatment of gingival recession: A randomized clinical trial. Int J Periodontics Restorative Dent 2012;32:e41-50.  Back to cited text no. 5

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