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 Table of Contents  
Year : 2015  |  Volume : 7  |  Issue : 5  |  Page : 181-183  

Naturally occurring products in cancer therapy

Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath University, Chennai, Tamil Nadu, India

Date of Submission31-Oct-2014
Date of Decision31-Oct-2014
Date of Acceptance09-Nov-2014
Date of Web Publication30-Apr-2015

Correspondence Address:
Dr. E Rajesh
Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath University, Chennai, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.155895

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Natural products have been used for the treatment of various diseases and are becoming an important research area for drug discovery. These products, especially phytochemicals have been extensively studies and have exhibited anti-carcinogenic activities by interfering with the initiation, development and progression of cancer through the modulation of various mechanisms including cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis. This concept is gaining attention because it is a cost-effective alternative to cancer treatment. In this article, we have discussed some of the naturally occurring products used in cancer treatment.

Keywords: Carcinogenesis, curcumin, quercetin

How to cite this article:
Rajesh E, Sankari LS, Malathi L, Krupaa JR. Naturally occurring products in cancer therapy. J Pharm Bioall Sci 2015;7, Suppl S1:181-3

How to cite this URL:
Rajesh E, Sankari LS, Malathi L, Krupaa JR. Naturally occurring products in cancer therapy. J Pharm Bioall Sci [serial online] 2015 [cited 2021 May 9];7, Suppl S1:181-3. Available from:

Oral cancer is defined as the cancer of mouth and pharynx including cancer of lips, tongue, floor of the mouth, palate, gingiva, alveolar mucosa, buccal mucosa, oropharynx, tonsils, uvula and salivary glands. Cancer is the biggest cause of mortality worldwide, responsible for 8.2 million death/year and rising according to the global scientific report released on the February 5, 2014. [1] Factors such as obesity, poor diet, tobacco, radiation, environmental pollutants, lack of physical activity and age increases cancer risk. These factors may cause cancer by damaging genes directly and/or indirectly in combination with existing genetic mutation within cells. [2]

   Epidemiology Top

Epidemiological studies have shown that diet containing fruits and vegetables reduce the risk of several types of cancer. [3] Intake of fruits and vegetables has been successfully used in the prevention of chronic disease associated with oxidative stress condition including cancer. [4],[5] WHO projects 10,000,000 cases of cancer per year worldwide and 6,000,000 deaths from cancer per year worldwide. And it also projected 15 million cases/year in 2020. It is been estimated that 80% of the world population relies on plant-based medicine for primary health care and 75% of all pharmaceuticals were discovered by examining the use of plants in traditional medicine.

   Carcinogenesis Top

The transformation of normal cell to cancer cell occurs through three distinct phases, initiation, promotion, and progression. Initiation of cancer occurs in the normal cells due to exposure of carcinogenic and mutagenic agents. The initiated cells are irreversibly altered and are at greater risk of neoplastic transformation. However, initiation alone is not sufficient for tumor formation. [6] In promotion phase, tumor promoters convert the initiated cells into neoplastic cells. [7],[8] Progression involves a stepwise evolution of neoplastic cells into higher degree of malignancy.

   Chemopreventive Agents in Oral Carcinogenesis Top

Various phytochemicals obtained from vegetables, fruits, spices, teas, herbs, and medicinal plants, such as flavonoids carotenoids, phenolic compounds and terpenoids, have been extensively investigated for their anti-cancer activities due to their safety, low toxicity and general availability. [9] In this article we discuss (a) use of phytochemicals, including curcumin, resveratrol, apigenin, quercetin, genistein, lycopene, isothiocyanates (b) their mechanism of action, such as anti-oxidant properties, inhibition of cell cycle, induction of apoptosis, regulation of angiogenesis.

   Curcumin Top

Curcumin (diferuloylmethane), a yellow pigment belongs to the class of polyphenols present in the rhizomes of turmeric is used in cooking in India. It is also used as a cosmetic and in some medical preparations. Multiple therapeutic activities of curcumin have also been considered to be associated with its anti-oxidant and anti-inflammatory properties. The anti-inflammatory effect of curcumin is most likely medicated through its ability to inhibit cyclooxygenase-2, lipoxygenase (LOX), and inducible nitric oxide synthase. [10] Curcumin has the capability to inhibit carcinogen bioactivation via suppression of specific cytochrome P450 isozymes, as well as to induce the activity or expression of phase II carcinogen detoxifyingenzymes. [11] Combination of phenethylisothiocyanate and curcumin caused suppression of epidermal growth factor (EGF) receptor phosphorylation and inhibition of EGF-induced phosphorylation and induction of phosphatidylinositol 3-kinase in prostate cancer-3 cells. [12] It regulates tumor cell growth through multiple cell signaling pathways, including cell proliferation pathway, cell survival pathway, caspase activation pathway, tumor suppressor pathway, death receptor pathway, mitochondrial pathways and protein kinase pathway.

   Resveratrol Top

Resveratrol (trans-3, 5, 4-tryhydroxystilbene) a naturally occurring phytoalexin, is found at a high concentration in the skin of red grapes and red wine. Resveratrol is known to have anti-oxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. [13] Resveratrol has been identified as an effective candidate for cancer prevention based on inhibitory effects on cellular events associated with cancer initiation, promotion, and progression. [14] It has been shown to inhibit tumor necrosis factor-α-mediated matrix metalloproteinase-9 expression in HepG2 cells by down regulation of the nuclear factor-kB signaling pathway. [15] Various studies revealed multiple intracellular targets of resveratrol, which affect cell growth, inflammation, apoptosis, angiogenesis, and invasion and metastasis. [16]

   Apigenin Top

Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables possesses anti-oxidant, anti-mutagenic, anti-carcinogenic, anti-inflammatory, anti-growth, and anti-progression properties. [17] Apigenin is effective in carcinogenesis, topical application of apigenin inhibited dimethyl benzanthracene-induced skin tumors, [18] and also diminished ultraviolet-induced cancer incidence and increased tumor free survival experiment. [19]

Earlier studies demonstrated that the apigenin promotes metal chelation, scavenges free radicals and stimulates phase II detoxification enzymes in cell culture and in vivo tumor models. [20]

   Quercetin Top

Quercetin is a dietary flavonoid abundant in variety of foods including apples, berries, brassica vegetables, grapes, onions, shallots, tea, and tomatoes as well as many seeds, nuts, barks and leaves. [21] It usually occurs as o-glycosides with D-glucose as glycosides have been identified. [22] Among polyphenols, quercetin is one of the most potent anti-oxidants, as demonstrated in different studies. [23],[24] It has been shown to inhibit oxidative species generating enzymes such as xanthine oxidase, LOX, and nicotinamide adenine dinucleotide phosphate oxidase. [25] It is a potent anti-cancer agent, exhibiting different activities such as cell cycle regulation, interaction with type II estrogen binding sites and tyrosine kinase inhibition. [26]

   Isothicyanates Top

Isothiocyanates (ITCs) are electrophilic compounds that play a major role in potential chemopreventive effects associated with high intake of cruciferous vegetables such as watercress, brussel sprouts, broccoli, cabbage, horseradish, radish, and turnip. [27] Cruciferous vegetables have been widely accepted as potential diet components that may decrease the risk of cancer. [28] Epidemiological studies show that the dietary intake of ITCs I associated with reduced risk of certain human cancers. [29] ITCS display anti-carcinogenic activity by reducing the activation of carcinogens and increase their detoxification.

Genistein and ursolic acid

Genistein is an isoflavone compound found in soybean and related products such as tofu, soy milk and soy sauce. [30] And is a promising cancer chemotherapeutic agent. [31] It inhibits the growth of cancer by increasing apoptosis, including cell cycle delays and modulating intercellular signaling pathways. [32]

Ursolic acid is a pentacyclic triterpene compound widely found in food, medicinal herbs, apple peel and is able to exhibit a wide range of pharmacological functions, including anti-oxidant, anti-tumor, anti-inflammatory activities. [33]

   Conclusion Top

Natural products play a major role in chemotherapy drugs, and primarily target proliferating tumor cells. Chemoprevention by phytochemicals is of great interest and is considered to be an inexpensive, readily applicable, acceptable, and accessible approach to cancer control and management. Several phytochemicals are in preclinical or clinical trials for cancer chemoprevention. Epidemiological studies have shown that high dietary consumption of vegetables and fruits reduced the risk of cancer. Severe toxicity is a major drawback in conventional radiotherapy and chemotherapy.

   References Top

Cancer Report worldwide. Press Release WCD 2014, Crisis of Cancer Impact Worldwide; 2014.  Back to cited text no. 1
Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 2008;25:2097-116.  Back to cited text no. 2
Donaldron MS. Nutrition and cancer. A review of the evidence for an anticancer diet. Nutrition journal 2004;3:1-21  Back to cited text no. 3
Riboli E, Norat T. Epidemiological evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003;78 (3 suppl):559-69s.  Back to cited text no. 4
Nichenametla SN, Taruscio TG, Barney DL, Exon JH. A review of the effects and mechanisms of polyphenolics in cancer. Crit Rev Food Sci Nutr 2006;46:161-83.  Back to cited text no. 5
Hollman PC, Katan MB. Dietary flavonoids: Intake, health effects and bioavailability. Food Chem Toxicol 1999;37:937-42.  Back to cited text no. 6
Di Carlo G, Mascolo N, Izzo AA, Capasso F. Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci 1999;65:337-53.  Back to cited text no. 7
Cragg GM, Newman DJ. Natural products branch. Developmental therapeutics program, Division of cancer, treatment and diagnosis. Maryland: National Cancer Institute; 2007. p. 461-77.  Back to cited text no. 8
Amin AR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol 2009;27:2712-25.  Back to cited text no. 9
Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. In: Aggarwal BB, Surh YJ, Shishodia S, editors. The Molecular Targets and Therapeutic Uses of Urcumin in Health and Disease. US, Texas: Springer; 2007. p. 105-25.  Back to cited text no. 10
Surh YJ, Chun KS. Cancer chemopreventive effects of curcumin. In: Aggarwal BB, Surh YJ, Shishodia S, editors. The Molecular Targets and Therapeutic Uses of Urcumin in Health and Disease. London: Springer; 2007. p. 149-72.  Back to cited text no. 11
Kim JH, Xu C, Keum YS, Reddy B, Conney A, Kong AN. Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin. Carcinogenesis 2006;27:475-82.  Back to cited text no. 12
Gagliano N, Aldini G, Colombo G, Rossi R, Colombo R, Gioia M, et al. The potential of resveratrol against human gliomas. Anticancer Drugs 2010;21:140-50.  Back to cited text no. 13
Huang X, Zhu HL. Resveratrol and its analogues: Promising antitumor agents. Anticancer Agents Med Chem 2011;11:479-90.  Back to cited text no. 14
Yu HB, Pan CE, Wu WJ, Zhao SH, Zhang HF. Effects of resveratrol on matrix metalloproteinase-9 expression in hepatoma cells. Zhong Xi Yi Jie He Xue Bao 2008;6:270-3.  Back to cited text no. 15
Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL. Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys 2009;486:95-102.  Back to cited text no. 16
Patel D, Shukla S, Gupta S. Apigenin and cancer chemoprevention: Progress, potential and promise (review). Int J Oncol 2007;30:233-45.  Back to cited text no. 17
Wei H, Tye L, Bresnick E, Birt DF. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res 1990;50:499-502.  Back to cited text no. 18
Birt DF, Mitchell D, Gold B, Pour P, Pinch HC. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res 1997;17:85-91.  Back to cited text no. 19
Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.  Back to cited text no. 20
Kelly GS. Quercetin. Monograph. Altern Med Rev 2011;16:172-94.  Back to cited text no. 21
Yang CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 2001;21:381-406.  Back to cited text no. 22
Bors W, Heller W, Michel C, Saran M. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol 1990;186:343-55.  Back to cited text no. 23
Prior RL. Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr 2003;78:570-8S.  Back to cited text no. 24
Day AJ, Bao Y, Morgan MR, Williamson G. Conjugation position of quercetin glucuronides and effect on biological activity. Free Radic Biol Med 2000;29:1234-43.  Back to cited text no. 25
Lamson DW, Brignall MS. Antioxidants and cancer, part 3: Quercetin. Altern Med Rev 2000;5:196-208.  Back to cited text no. 26
Cavell BE, Alwi SS, Donlevy A, Packham G. Antiangiogenic effects of dietary isothiocyanates; mechanisms of action and implications for human health. Biochem Pharmacol 2010;81:327-36.  Back to cited text no. 27
Lam TK, Gallicchio L, Lindsley K, Shiels M, Hammond E, Tao XG, et al. Cruciferous vegetable consumption and lung cancer risk: A systematic review. Cancer Epidemiol Biomarkers Prev 2009;18:184-95.  Back to cited text no. 28
Mi L, Di Pasqua AJ, Chung FL. Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis 2011;32:1405-13.  Back to cited text no. 29
Fotsis T, Pepper M, Adlercreutz H, Hase T, Montesano R, Schweigerer L. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr 1995;125:790-7S.  Back to cited text no. 30
Li W, Frame LT, Hirsch S, Cobos E. Genistein and hematological malignancies. Cancer Lett 2010;296:1-8.  Back to cited text no. 31
Barnes S. Effect of genistein on in vitro and in vitro models of cancer. J Nutr 1995;125 3 Suppl: 777-83S.  Back to cited text no. 32
Mizushina Y, Iida A, Ohta K, Sugawara F, Sakaguchi K. Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem J 2000;350:757-63.  Back to cited text no. 33

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