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DENTAL SCIENCE - REVIEW ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 5  |  Page : 197-199

DNA adducts-chemical addons


1 Department of Oral Pathology, Sree Balaji Dental College and Hospital, Chennai, Tamil Nadu, India
2 Department of Oral Pathology, Madha Dental College, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. T R Rajalakshmi
Department of Oral Pathology, Sree Balaji Dental College and Hospital, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.155901

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DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication. This could be the start of a mutation and without proper DNA repair, this can lead to cancer. It is this chemical that binds with the DNA is our prime area of concern. Instead of performing the whole body analysis for diagnosing cancer, this test could be carried out for early detection of cancer. When scanning tunneling microscope is used, the DNA results can be obtained earlier. DNA adducts in scientific experiments are used as biomarkers.


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