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MEDICAL SCIENCE - RESEARCH ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 5  |  Page : 40-45

Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats


1 Department of Pharmacology, Dr. A. L. M. P. G. Institute of Basic Medical Sciences, Chennai, Tamil Nadu, India
2 Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu, India
3 Department of Pharmacology, Tagore Dental College, Kanchipuram, Tamil Nadu, India
4 Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. V Ramesh
Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.155791

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Background: Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity. Objective: The present study was carried out to evaluate the antioxidant activity of ethanolic extract of Tinospora cordifolia (EETC) in N-nitrosodiethylamine (DEN) induced liver cancer in male Wister albino rats. Materials and Methods: The antioxidant activity was assessed by the levels of lipid peroxidation (LPO), enzymic and nonenzymic antioxidants. Result: A significant levels of LPO was increased as the enzymic and nonenzymic antioxidants values were decreased in liver cancer bearing animals. Conclusions: The administration of EETC to cancer bearing animals reverted the LPO levels, enzymic and nonenzymic antioxidants to near normal


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