Molecular pathogenesis and diagnostic imaging of metastatic jaw tumors

Kenniyan Kumar Srichinthu; Arjun Parameshwar Raveendran; Periyasamy Tamilthangam; Joseph Joe; Charanya Duraisamy; Thukanayakanpalayam Ragunathan Yoithapprabhunath; Chitturi Ravi Teja

doi:10.4103/jpbs.JPBS_138_17

Journal of Pharmacy And Bioallied Sciences

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Year : 2017 | Volume : 9 | Issue : 5 | Page : 15-22

Molecular pathogenesis and diagnostic imaging of metastatic jaw tumors

Kenniyan Kumar Srichinthu¹, Arjun Parameshwar Raveendran², Periyasamy Tamilthangam³, Joseph Joe⁴, Charanya Duraisamy⁵, Thukanayakanpalayam Ragunathan Yoithapprabhunath³, Chitturi Ravi Teja⁶
¹ Department of Oral and Maxillofacial Pathology, KSR Institute of Dental Science and Research, Elayampalayam, Thiruchengodu, Namakkal, Tamil Nadu, India
² Departments of Oral and Maxillofacial Pathology, Pushpagiri College of Dental Sciences, Perumthuruthy, Kerela, India
³ Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Elayampalayam, Thiruchengodu, Namakkal, Tamil Nadu, India
⁴ Departments of Orthodontics, Pushpagiri College of Dental Sciences, Perumthuruthy, Kerela, India
⁵ Department of Oral Medicine and Radiology, Regional Institute of Medical Sciences, Manipur, India
⁶ Department of Oral Biology, The University of the West Indies, St. Augustine, Trinidad and Tobago

Correspondence Address:
Thukanayakanpalayam Ragunathan Yoithapprabhunath
Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Elayampalayam, Thiruchengodu, Namakkal - 637 205, Tamil Nadu
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jpbs.JPBS_138_17

Metastasis is the spread of malignant cells from a primary tumor to distant sites through lymphatics or blood vessels. Malignant lesions metastasizing to the oral and perioral region are a rarity indeed. Malignant lesions could metastasize to both soft tissue of oral cavity and the hard tissues of the jaws and recent meta-analysis showed that metastasis is more common in the jaws than oral soft tissues because of rich vascular supply. The incidence is very low when compared to the incidence of primary oral cancers; nevertheless, one has to include in the diagnostic workup, metastatic malignant lesions, when an irregular ill-defined radiolucency or radiodensity with ragged edges in noted. It could be a challenging task for a diagnostician, in cases with the presence and location of the primary tumor is unknown. Advanced oral imaging technologies and biochemical markers play a vital role in diagnosing such lesions.

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