Assessment of total antioxidant capacity and antimicrobial activity of Glycyrrhiza glabra in saliva of HIV-infected patients

Eby Aluckal; Asif Ismail; Anoopa Paulose; Sanju Lakshmanan; MS Balakrishnan; Benoy Mathew; M Vikneshan; Abraham Kunnilathu

doi:10.4103/jpbs.JPBS_141_17

Journal of Pharmacy And Bioallied Sciences

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ORIGINAL ARTICLE

Year : 2017 | Volume : 9 | Issue : 5 | Page : 237-240

Assessment of total antioxidant capacity and antimicrobial activity of Glycyrrhiza glabra in saliva of HIV-infected patients

Eby Aluckal¹, Asif Ismail², Anoopa Paulose³, Sanju Lakshmanan⁴, MS Balakrishnan⁵, Benoy Mathew⁶, M Vikneshan⁷, Abraham Kunnilathu⁸
¹ Department of Public Health Dentistry, Mar Baselios Dental College, Kothamangalam, Kerala, India
² Department of Pedodontics, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India
³ Department of Prosthodontics, Mar Baselios Dental College, Kothamangalam, Kerala, India
⁴ Department of Oral and Maxillofacial Surgery, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India
⁵ Department of Oral and Maxillofacial Surgery, Malabar Dental College and Research Center, Edappal, Kerala, India
⁶ Department of Orthodontics, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India
⁷ Department of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Pondicherry, India
⁸ Department of Public Health, Western University, Ontario, Canada

Correspondence Address:
Eby Aluckal
Department of Public Health Dentistry, Mar Baselios Dental College, Kothamangalam - 686 691, Kerala
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jpbs.JPBS_141_17

Objectives: The objectives of this study were to evaluate the antimicrobial activity and total antioxidant capacity (TAC) of licorice in Saliva of HIV/AIDS patients. Materials and Methods: Saliva specimens were collected from 20 people living with HIV infection, with CD4 count <500 cells/mm³ from people infected with HIV/AIDS in Mangalore city, India. A combination of amoxicillin-clavulanic acid and nystatin was taken as the positive control and normal saline as negative control. Results were compared using one-way analysis of variance followed by Tukey's post hoc analysis in SPSS 19. Results: The TAC was evaluated spectrophotometrically at 695nm using the phosphomolybdenum method. Glycyrrhiza glabra showed a statistically significant reduction (P < 0.05) in total Candida count. The TAC of G. glabra was found to be 4.467 mM/L. Conclusions: G. glabra extracts showed good anticandidal activity and also high antioxidant property which reduces the oxidative stress of HIV-infected people.

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