Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 2009  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission

 Table of Contents  
Year : 2018  |  Volume : 10  |  Issue : 1  |  Page : 1-6  

Evaluation of bloodletting cupping therapy in the management of hypertension

1 Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates
2 Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates

Date of Web Publication20-Mar-2018

Correspondence Address:
Dr. Moawia M Al-Tabakha
Moawia Mohammad Al-Tabakha, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, P.O. Box 346, Ajman
United Arab Emirates
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpbs.JPBS_242_17

Rights and Permissions

Background: Bloodletting cupping therapy (Hijama) is a traditional alternative medicine practiced in different cultures. Claims about the therapeutic efficacy of Hijama in hypertension are contradictory. The aim of this project was to determine if Hijama therapy is beneficial in the treatment of patients with hypertension. Materials and Methods: In this retrospective study, 60 files for patients treated for hypertension, aged 40–60 years and whose systolic blood pressure (SBP) is at least 140mm Hg, were used. The data from 30 patient files were obtained from three licensed Hijama centers (study group), whereas data from the rest of 30 patient files were collected from a hospital (control group). The data from Hijama centers included age, date of Hijama therapy, and blood pressure measured before each Hijama session. Both diastolic blood pressure (DBP) and SBP data were obtained over 3-month period. Results: The results showed a significant reduction in SBP (P value < 0.01) over three sessions of wet cupping (from 149.2 to 130.8mm Hg), but this was not significant for DBP over three sessions (P = 0.074). The study also found that the mean SBP in the study group was 9.6mm Hg less than that in the control group (130.8 vs. 140.4mm Hg, P = 0.019), whereas there was no significant difference in DBP between the study group and the control group (87.0 vs. 86.0mm Hg, P = 0.75). Conclusions: Our study shows clear relationship between Hijama and the reduction and control of SBP in patients with hypertension. Therefore, Hijama can be used as an adjunct to conventional therapy, which may allow downtitration of given doses of antihypertensive drugs. The possible association of SBP reduction by Hijama and pain reduction needs an investigation.

Keywords: Bloodletting cupping therapy, diastolic blood pressure, Hijama, hypertension, retrospective, systolic blood pressure

How to cite this article:
Al-Tabakha MM, Sameer FT, Saeed MH, Batran RM, Abouhegazy NT, Farajallah AA. Evaluation of bloodletting cupping therapy in the management of hypertension. J Pharm Bioall Sci 2018;10:1-6

How to cite this URL:
Al-Tabakha MM, Sameer FT, Saeed MH, Batran RM, Abouhegazy NT, Farajallah AA. Evaluation of bloodletting cupping therapy in the management of hypertension. J Pharm Bioall Sci [serial online] 2018 [cited 2021 Dec 8];10:1-6. Available from:

   Introduction Top

Bloodletting cupping (BLC) therapy (i.e., Hijama[1]) is a traditional alternative medicine practiced in different cultures such as China, Greek, Arab, Turkish, and Persian and can be traced back to more than 2000 years.[2],[3],[4],[5] It has been claimed to control and prevent certain diseases and to maintain homeostasis.[6] Regardless of its common use in many countries, the evidence to support its practice to promote patients’ health and improve quality of life is incomplete.[7],[8]

Different types of cupping appear in literature, including dry cupping, wet cupping, moving cupping, and fire cupping.[2],[9],[10],[11] All types involve suction created by various means with or without bloodletting. The wet cupping Hijama technique includes applying suction to the desired points on the skin using plastic, bamboo, earthenware, silicone, or glass cup. Thereafter, incisions are applied to the same areas of the skin to remove and suck the blood into the replaced cups.

Studies aimed to establish or correlate the beneficial effects of Hijama therapy in various health conditions were mainly able to associate beneficial effects to different kinds of pain, including neck pain, upper shoulder pain, and low back pain.[8],[12],[13],[14],[15],[16],[17] In addition, tension and migraine headache,[18] acute/chronic inflammation, infectious diseases,[19] immune system disorders, diabetes,[20] anxiety and depression,[21] sleep quality,[22] heart rate variability,[23] and hypertension have been investigated.[24] Of particular interest was the control of hypertension because contradictory findings have been reported. For example, one registered clinical trial showed that there were no significant differences in the systolic blood pressure (SBP) or diastolic blood pressure (DBP) between the cupping therapy group and the control group.[25] On the other hand, studies with larger number of participants have shown that cupping can have beneficial effects on blood pressures (BPs), although long-time benefits were not investigated.[26]

The claim that Hijama therapy may be beneficial to patients with hypertension was based on the removal of both excess interstitial and intravascular fluid and harmful metabolic substances.[27] It was also proposed that Hijama therapy stimulates endogenous nitric oxide production and excretion, including accumulated vasoactive substances and free radicals,[28] which may result in reduced BP measurements. Hijama professionals believe that causes of illness can be either superficial or exist in deeper organs, which have a link with the skin at certain points.[29] These pathologies can be removed when a negative pressure is applied through superficial clean incisions, thus enhancing the flow of blood. Such explanation, however, is superficial and is not substantiated by enough evidence.

The objective of this retrospective observational study was to assess whether applying Hijama therapy helps in the reduction of SBP and DBP compared to a control group within three session periods.

   Materials and Methods Top

To conduct this retrospective case–control study, ethical approval was obtained from research ethics committee of Ajman University. The participating centers and the hospital were all licensed from the Ministry of Health in the United Arab Emirates (UAE). Three Hijama centers in Ajman and Sharjah cities (UAE) were visited to obtain data from admitted patients with hypertension seeking Hijama therapy, whereas one participating hospital in Dubai city (UAE) was used to obtain data from patients with hypertension already taking the prescribed treatment. The required consents were obtained from the patients/hospital/centers to use the data for the purpose of this research.

Sample size

Data were collected in the period between October 15, 2017, and November 15, 2017, with a sample size of 60 patients. The patients were divided into two groups: the study group (30 patients’ files) and the control group (30 patients’ files). The primary outcome under investigation was SBP lowering. A difference of at least 10mm Hg between the two groups was considered significant in this study. The sample size was calculated based on study power of 85%, α error rate of 0.05, and SBP population standard deviation for hypertensive of 13mm Hg (from literature review).

Inclusion and exclusion criteria

At Hijama centers, patient’s file was used if the patient sought Hijama therapy for the primary purpose of hypertension management and continued for at least three sessions.

Patients also needed to meet the following criteria for their files to be used:

  1. Gender: male.
  2. For Hijama centers, patients must have undergone cupping therapy for three consecutive sessions, and their BP was measured before each session. The gap between one session and another is approximately 1 month.
  3. Patients who are between 40 and 60 years of age.
  4. For Hijama centers, files of patients were used whether or not the patient was taking medication for hypertension, whereas for data from the hospital included patients under conventional antihypertensive treatment.
  5. SBP is at least 140mm Hg.

Patients’ files were excluded if the patients had the following:

  1. Kidney disease
  2. Donated blood (1 month before cupping therapy)
  3. Bleeding diathesis (unusual susceptibility to bleed)
  4. SBP of more than 180mm Hg

Cupping therapy

Cupping therapy specialist decides the cupping points required to treat specific diseases/conditions. For hypertension, the participating centers applied cups to the same standard sites known to the professionals. The Hijama therapy was performed in the following way: The sites where the cups are applied are first sterilized with alcohol swabs. The cups are then placed on the selected sites, negative pressure is created by a suction pump, and then cups are left for 5min to form congestions beneath them. After the removal of the cups, superficial incisions are made using sterilized blades on each congestion. The cups are placed again and vacuumed to remove blood from the sites until they are full. The cups are then removed. The bleeding areas are then cleansed using alcohol swabs and then bandaged.

Data analysis

One-way analysis of variance and Student’s t-test were used for comparison and to make inferences regarding the effect of Hijama therapy on hypertension. The 95% confidence interval (CI) assuming α = 0.05 and two-tail test were applied in the tests. Analysis was done using SPSS, version 21 (SPSS, Chicago, IL), and Excel 2013 (Microsoft Corporation, Redmond, WA, D.C.) was used for the preparation of the graph.

   Results Top

The baseline line characteristics of the study and the control groups are given in [Table 1]. The age of the control group did not differ significantly from that of the study group (P = 0.96). The age range in both the study and the control groups was from 40 to 60 years. Likewise, both DBP (P = 0.74) and SBP (P = 0.29) showed similar values. In the study group, DBP ranged from 70 to 110mm Hg, whereas in the control group, it was from 70 to 113mm Hg. On the other hand, in the study group, SBP ranged from 140 to 170mm Hg, whereas in the control group, it was from 140 to 172mm Hg.
Table 1: Baseline characteristics of the study and control groups

Click here to view

For patients undergoing Hijama therapy, SBP had improved with each session and gave best results at the third session. For example, on the third session, SBP decreased from baseline 149.2 (95% CI: 146.1–152.3mm Hg) to 130.8 (95% CI: 127.1–134.6mm Hg), (P < 0.001). Similarly, the control group undergoing conventional therapy witnessed a decrease in SBP from 151.8 to 140.4mm Hg (P = 0.006). Comparing the two groups (at the third Hijama session with control group after 2 months of conventional therapy), it was clear that the Hijama group achieved better (−9.6mm Hg) pressure reduction (P = 0.019).

In comparison, DBP at the third Hijama session decreased from a baseline value of 92.5 (95% CI: 88.2–96.8mm Hg) to 87.0 (95% CI: 83.0–91.0mm Hg); however, this was not significant (P = 0.06). On the contrary, DBP with conventional therapy decreased significantly from 93.4 to 86.0mm Hg (P = 0.014). When comparing DBP at the third Hijama session with the control group, no significance was shown (P = 0.75). [Figure 1] shows the changes in SBP and DBP over the three sessions of Hijama therapy.
Figure 1: Changes in systolic and diastolic blood pressures over three sessions of Hijama therapy. Error bars represent standard deviation

Click here to view

The percentage of patients with hypertension who had their SBP less than 140mm Hg at the third Hijama session was 73.3%, whereas this was 46.7% in the case of conventional treatment. This shows that much less patients would be diagnosed with hypertension at the third session compared to the conventional therapy. On the other hand, 43.3% patients who underwent Hijama therapy had their DBP less than 90mm Hg compared to 66.7% of those with conventional treatment.

   Discussion Top

The baseline characteristics indicate that the two samples have similar characteristics to provide valid comparison. Although SBP clearly decreased with the use of Hijama therapy, this was not shown for DBP. According to the findings of one study published in 2014, there was no significant difference in SBP or DBP between the Hijama and control groups, and the authors explained this to be due to the small sample size.[25] Another study conducted in 2015 with a larger sample size showed that Hijama therapy is effective for reducing SBP in patients with hypertension.[26] A more recent study has shown that while SBP changed significantly before and after wet cupping, there was no significant difference in DBP,[30] in agreement with our results.

Ibrahim et al.[31] published a study in 2016 based on the face-to-face interviews with patients having hypertension (n = 20) seeking complementary and alternative medicines (CAMs) other than their prescribed medicines, which indicated that 35% of the participants have tried Hijama therapy because of religious beliefs or friend’s recommendation and have reported feeling better, whereas only 30% reported adhering to the treatment prescribed by their physician. The low adherence to medication reported in the study was not consistent with another study showing more than 70% adherence to antihypertensive medication.[32] One recent review indicated that not only high proportion of patients with hypertension sought CAMs but also many used antihypertensive medications concurrently with analgesics and other herbal products.[33] Physicians treating their patients for hypertension should consistently ask them about over-the-counter (OTC) medicines and CAMs they are using, and whether they are adhering to their prescribed medication.

Several reasons were put forward to explain how Hijama therapy could reduce BP. The removal of blood (which can be more than 50mL) by Hijama procedure reduces its volume in the arteries and will have a direct effect on BP.[26] It is, however, unlikely that the small volume that can be compensated rapidly from cellular and extracellular fluid would have a significant lasting effect. Although it is well proven that Hijama therapy can reduce various types of pain and because pain has been associated with hypertension,[34],[35],[36],[37] it is possible that Hijama acts directly and/or indirectly on BP by reducing pain. Pain has the ability to increase sympathetic activity and therefore increase BP. Also, many patients are prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) to control their pain. This, however, would reduce the beneficial effect of antihypertensive drugs such as the diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, and perhaps the calcium-channel blockers.[38],[39],[40],[41] So, reducing pain would reduce the sympathetic pressor effect (direct effect) and also would reduce the intake of NSAIDs (indirect effect), which altogether would lead to BP reduction. This hypothesis requires future focused controlled clinical trials.

This study is an observation case–control study (retrospective), and to provide a greater insight into the beneficial effect of Hijama intervention, a carefully controlled clinical trial with large sample size and appropriate length of time and Hijama sessions is recommended. Controlled clinical trials testing the effects of Hijama were previously conducted. A recent randomized controlled trial included adequate number of participants (40 participants in each study and control group), but the length of time applied in the study does not permit to generalize conclusion on the use of Hijama therapy for the management of hypertension. That study showed Hijama to be more effective than the conventional treatment alone when used for up to 4 weeks, but not 8 weeks.[26] Prior clinical trials involving small groups of not more than 20 participants did not provide evidence of the effectiveness of Hijama therapy on hypertension. It is also difficult to isolate the individual effect of Hijama therapy on BP if the study group participants are allowed to continue using their hypertension treatment while undergoing Hijama therapy; however, asking the participants to stop their conventional treatment will be unethical, especially with the need for lead-in phase to washout the antihypertensive treatment from the system. Furthermore, a mechanistic study is required to prove or refute our theory that Hijama therapy works indirectly on BP by alleviating pain. Also, it is needed to know the session at which Hijama produces its maximum beneficial effect and adequate follow-up period to provide information about its long-term safety and efficacy.

   Conclusion Top

The results of this study indicate that Hijama can be used effectively to reduce SBP. Therefore, if used in conjunction with the conventional antihypertensive agents, downtitration of the medication used will reduce the untoward side effects while attaining the required BP targets. Common adverse effects of antihypertensive drugs include cough, diarrhea or constipation, erection problems, tiredness, headache, and dizziness or lightheadedness. It is important for the physician prescribing antihypertensive medications to be aware of OTC medicines and CAMs used by their patients and whether they adhere to their prescribed drugs.

The long-term benefits from Hijama need further investigation to provide evidence of sustained effect. It is also important to provide scientific explanation of how Hijama may be able to reduce BP alone and in combination with hypertensive medications. We theorize that this effect may be related to pain reduction.


Our utmost appreciation goes to the participating Hijama centers for allowing access to patients' files after getting their consent, with special thanks to the working staff in these centers who appreciated the importance

of this study and offered their help and support. This appreciation covers Dr. Sied Almrakby from Al Sultan

Medical Center (Ajman, UAE), Dr. Syed Asaduddin Ahmed from Al Hijama Alternative Medical Center (Sharjah, UAE), and Dr. Haiman El Nahal from International Holistic Health Center (Sharjah, UAE). We further extend our sincere gratitude to the Iranian hospital in Dubai for their continuous support.

The work received ethical approval before the start of the study from the University Research Ethics Committee (number F-H-17-08-01).

Financial support and sponsorship

This research is self-funded. We certify that no funding has been received for the conduct of this study and/or preparation of this manuscript.

Conflicts of interest

Each author of this manuscript declares no conflicts of interest.

Authors' Statement

We all have read and approved the manuscript and we satisfy the requirements for authorship as stated in the journal's "instructions to authors". Each author believes that the manuscript represents honest work and authors alone are responsible for the content and writing of the paper.

   References Top

Abbasi M, Norouzadeh R, Gholizadeh M, Heidari S, Gholizadeh L. Determining the Clients’ knowledge about the Rules of Hijama. Health Spiritual Med Ethics 2014;1:33-41.  Back to cited text no. 1
Mehta P, Dhapte V. Cupping therapy: A prudent remedy for a plethora of medical ailments. J Tradit Complement Med 2015;5:127-34.  Back to cited text no. 2
Albedah A, Khalil M, Elolemy A, Elsubai I, Khalil A. Hijama (cupping): A review of the evidence. Focus Altern Complement Ther 2011;16:12-6.  Back to cited text no. 3
Chen B, Li MY, Liu PD, Guo Y, Chen ZL. Alternative medicine: An update on cupping therapy. QJM 2015;108:523-5.  Back to cited text no. 4
Noorelahi M, Badawi A, Kasim K, Abo Haded HM. Health profile and quality of life before and after Hijama: A population-based cross-sectional study in Madinah, Saudi Arabia. Int J Sci Res 2016;5:431-4.  Back to cited text no. 5
Hekmatpou D, Moeini L, Haji-Nadali S. The effectiveness of wet cupping vs. venesection on arterial O2 saturation level of cigarette smokers: A randomized controlled clinical trial. Pak J Med Sci 2013;29:1349-53.  Back to cited text no. 6
Cao H, Li X, Liu J. An updated review of the efficacy of cupping therapy. PLoS One 2012;7:e31793.  Back to cited text no. 7
Lee MS, Kim JI, Ernst E. Is cupping an effective treatment? An overview of systematic reviews. J Acupunct Meridian Stud 2011;4:1-4.  Back to cited text no. 8
Mohammed M, Ghani Z. Current research cupping therapy: Well forgotten therapy. Analg Resusc Curr Res 2016;5:1-2.  Back to cited text no. 9
Cao H, Han M, Li X, Dong S, Shang Y, Wang Q, et al. Clinical research evidence of cupping therapy in china: A systematic literature review. BMC Complement Altern Med 2010;10:70.  Back to cited text no. 10
Kim JI, Lee MS, Lee DH, Boddy K, Ernst E. Cupping for treating pain: A systematic review. Evid Based Complement Alternat Med 2011;2011:467014.  Back to cited text no. 11
Arslan M, Gökgöz N, Dane Ş. The effect of traditional wet cupping on shoulder pain and neck pain: A pilot study. Complement Ther Clin Pract 2016;23:30-3.  Back to cited text no. 12
AlBedah A, Khalil M, Elolemy A, Hussein AA, AlQaed M, Al Mudaiheem A, et al. The use of wet cupping for persistent nonspecific low back pain: Randomized controlled clinical trial. J Altern Complement Med 2015;21:504-8.  Back to cited text no. 13
Kim JI, Kim TH, Lee MS, Kang JW, Kim KH, Choi JY, et al. Evaluation of wet-cupping therapy for persistent non-specific low back pain: A randomized, waiting-list controlled, open-label, parallel-group pilot trial. Trials 2011;12:146.  Back to cited text no. 14
Yuan Q, Guo T, Liu L, Sun F, Zhang Y. Traditional Chinese medicine for neck pain and low back pain: A systematic review and meta-analysis. PLoS One 2015;10:e0117146.  Back to cited text no. 15
Abdullah A, Mohamed K, El-Olemy A. Cupping in pain management. Eur J Integr Med 2012;4:135.  Back to cited text no. 16
Rozenfeld E, Kalichman L. New is the well-forgotten old: The use of dry cupping in musculoskeletal medicine. J Bodyw Mov Ther 2016;20:173-8.  Back to cited text no. 17
Ahmadi A, Schwebel DC, Rezaei M. The efficacy of wet-cupping in the treatment of tension and migraine headache. Am J Chin Med 2008;36:37-44.  Back to cited text no. 18
Cao H, Zhu C, Liu J. Wet cupping therapy for treatment of herpes zoster: A systematic review of randomized controlled trials. Altern Ther Health Med 2010;16:48-54.  Back to cited text no. 19
Vakilinia SR, Bayat D, Asghari M. Hijama (wet cupping or dry cupping) for diabetes treatment. Iran J Med Sci 2016; 41:S37.  Back to cited text no. 20
Farahmand SK, Gang LZ, Saghebi SA, Mohammadi M, Mohammadi S, Mohammadi G, et al. Does wet cupping on the interscapular region improve depression and anxiety? Focus Altern Complement Ther 2014;19:64-69.  Back to cited text no. 21
Cikar S, Ustundag G, Haciabdullahoglu S, Yuksel S, Dane S. Wet cupping (Hijamah) increases sleep quality. Clin Investig Med 2015;38:E258-E261.  Back to cited text no. 22
Arslan M, Yeşilçam N, Aydin D, Yüksel R, Dane S. Wet cupping therapy restores sympathovagal imbalances in cardiac rhythm. J Altern Complement Med 2014;20:318-21.  Back to cited text no. 23
Shekarforoush S, Foadoddini M, Noroozzadeh A, Akbarinia H, Khoshbaten A. Cardiac effects of cupping: Myocardial infarction, arrhythmias, heart rate and mean arterial blood pressure in the rat heart. Chin J Physiol 2012;55:253-8.  Back to cited text no. 24
Aleyeidi N, Aseri K, Kawthar A. The efficacy of wet cupping on blood pressure among hypertension patients in Jeddah, Saudi Arabia: A randomized controlled trial pilot study. Altern Integ Med 2014;4:1-4.  Back to cited text no. 25
Aleyeidi NA, Aseri KS, Matbouli SM, Sulaiamani AA, Kobeisy SA. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. J Integr Med 2015;13:391-9.  Back to cited text no. 26
Tagil SM, Celik HT, Ciftci S, Kazanci FH, Arslan M, Erdamar N, et al. Wet-cupping removes oxidants and decreases oxidative stress. Complement Ther Med 2014;22:1032-6.  Back to cited text no. 27
Akyol O, Erdemli HK. A new remedial approach to oxidant/antioxidant imbalance-based diseases: Wet-cupping therapy. Complement Ther Med 2015;23:633.  Back to cited text no. 28
Ahmed A. Innovative energy standard of curative cupping/Hijama. J Basic Appl Sci 2015;11:445-453.  Back to cited text no. 29
Zarei M, Hejazi S, Javadi A. The efficacy of wet cupping in treatment of hypertension. ARYA Atherosclerosis Journal 2012;8:1-4.  Back to cited text no. 30
Ibrahim IR, Hassali MA, Saleem F, Al Tukmagi HF. A qualitative insight on complementary and alternative medicines used by hypertensive patients. J Pharm Bioallied Sci 2016;8:284-8.  Back to cited text no. 31
Baran AK, Demirci H, Budak E, Candar A, Akpınar Y. What do people with hypertension use to reduce blood pressure in addition to conventional medication—Is this related to adherence? Eur J Integr Med 2017;13:49-53.  Back to cited text no. 32
Rahmawati R, Bajorek B V. Self-medication among people living with hypertension: A review. Fam Pract 2017;34:147-53.  Back to cited text no. 33
Bruehl S, Olsen RB, Tronstad C, Sevre K, Burns JW, Schirmer H, et al. Chronic pain-related changes in cardiovascular regulation and impact on comorbid hypertension in a general population: The Troms study. Pain 2018;159:119-27.  Back to cited text no. 34
Bae YH, Shin JS, Lee J, Kim MR, Park KB, Cho JH, et al. Association between hypertension and the prevalence of low back pain and osteoarthritis in Koreans: A cross-sectional study. PLoS One 2015;10:e0138790.  Back to cited text no. 35
Kitaoka M, Mitoma J, Asakura H, Anyenda OE, Nguyen TT, Hamagishi T, et al. Erratum to: the relationship between hypertension and health-related quality of life: Adjusted by chronic pain, chronic diseases, and life habits in the general middle-aged population in Japan. Environ Health Prev Med 2016;21:215-23.  Back to cited text no. 36
Biondi DM, Xiang J, Etropolski M, Moskovitz B. Evaluation of blood pressure and heart rate in patients with hypertension who received tapentadol extended release for chronic pain: A post hoc, pooled data analysis. Clin Drug Investig 2014;34:565-76.  Back to cited text no. 37
Aljadhey H, Tu W, Hansen RA, Blalock SJ, Brater DC, Murray MD. Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension. BMC Cardiovasc Disord 2012;12:93.  Back to cited text no. 38
Fournier JP, Sommet A, Bourrel R, Oustric S, Pathak A, Lapeyre-Mestre M, et al. Non-steroidal anti-inflammatory drugs (NSAIDs) and hypertension treatment intensification: A population-based cohort study. Eur J Clin Pharmacol 2012;68:1533-40.  Back to cited text no. 39
Bavry AA, Khaliq A, Gong Y, Handberg EM, Cooper-Dehoff RM, Pepine CJ. Harmful effects of NSAIDs among patients with hypertension and coronary artery disease. Am J Med 2011;124:614-20.  Back to cited text no. 40
White WB. Cardiovascular risk, hypertension, and NSAIDs. Curr Pain Headache Rep 2007;11:428-35.  Back to cited text no. 41


  [Figure 1]

  [Table 1]

This article has been cited by
1 Cupping Therapy for Migraine: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials
Jihye Seo, Hongmin Chu, Cheol-Hyun Kim, Kang-Keyng Sung, Sangkwan Lee, Arthur De Sá Ferreira
Evidence-Based Complementary and Alternative Medicine. 2021; 2021: 1
[Pubmed] | [DOI]
2 The Effect of Wet Cupping Therapy on Blood Pressure and Total Cholesterol on Healthy Young Male Adults
Syahruramdhani Syahruramdhani, Falasifah Ani Yuniarti, Tri Ega Septiana, Evi Mustikasari
Open Access Macedonian Journal of Medical Sciences. 2021; 9(T4): 172
[Pubmed] | [DOI]
3 The Effect of Wet Cupping on Baroreceptor Sensitivity in Hypertensive Patients in Sidenreng Rappang Regency, South Sulawesi
Fadli Fadli, Sumbara Sumbara, Arabta M. Peraten Pelawi, Suratun Suratun, Rohandi Baharuddin
Open Access Macedonian Journal of Medical Sciences. 2021; 9(G): 217
[Pubmed] | [DOI]
4 Complementary Alternative Medicine: Kombinasi Terapi Bekam dan Murotal Alquran pada Perubahan Tekanan Darah, Glukosa, Asam Urat dan Kolesterol
Lilin Rosyanti, Indriono Hadi, Askrening Askrening, Maman Indrayana
Health Information : Jurnal Penelitian. 2020; 12(2): 173
[Pubmed] | [DOI]
5 Wet cupping therapy ameliorates pain in patients with hyperlipidemia, hypertension, and diabetes: A controlled clinical study
Heshu Sulaiman Rahman, Govand Ali Ahmad, Baram Mustapha, Hisham Arif Al-Rawi, Ridha Hassan Hussein, Kawa Amin, Hemn Hassan Othman, Rasedee Abdullah
International Journal of Surgery Open. 2020; 26: 10
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Materials and Me...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded177    
    Comments [Add]    
    Cited by others 5    

Recommend this journal