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ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 6  |  Page : 232-235

Analysis of Ki-67 expression in oral premalignant lesions and normal oral mucosa: An immunohistochemical study


1 Department of Oral Pathology, Educare Institute of Dental Sciences, Malappuram, Kerala, India
2 Department of Oral Surgery, Educare Institute of Dental Sciences, Malappuram, Kerala, India
3 Department of Oral Medicine and Radiology, Educare Institute of Dental Sciences, Malappuram, Kerala, India

Correspondence Address:
Dr. Suhas Ramananda Nayak
Department of Oral Pathology, Educare Institute of Dental Sciences, Malappuram 676504, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JPBS.JPBS_305_18

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Aim: This study aimed to evaluate the Ki-67 expression in oral premalignant lesions and normal oral mucosa. Materials and Methods: The cases were selected on the basis of the details obtained from the patients. A total of 45 specimens were divided into three groups: Group 1 (normal mucosa), Group 2 (clinically and histologically diagnosed as oral lichen planus), and Group 3 (clinically and histologically diagnosed as leukoplakia). Specimens were prepared and the slides for Ki-67 were observed under light microscope with a magnification of ×400. The tissue samples were thoroughly examined, and the pattern of expression was analyzed semiquantitatively by counting the number of positive cells. Results: The mean positive cell count of normal mucosa was 23.20±2.89, of oral lichen planus was 42.82±2.65, and of leukoplakia was 82.14±3.10. There was a statistically significant difference of expression observed between the groups (P < 0.001). On multiple comparisons using Tukey post hoc test, a statistical difference was found between all the three groups. Conclusion: Ki-67 is an easily applicable marker of cell proliferation whose expression correlates well with the disease progression.


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